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MGI:Pnp1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Pnp ( synonyms: Np, Np-1, Np-2, Pnp, Pnp1 ) | |
| Protein Name(s) | purine-nucleoside phosphorylase, | |
| External Links | ||
| MGI | MGI:97365 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001882 |
nucleoside binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0001916 |
positive regulation of T cell mediated cytotoxicity |
MGI:MGI:1859999 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386195 |
P |
From MGI |
||
| GO:0002060 |
purine base binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003824 |
catalytic activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004731 |
purine-nucleoside phosphorylase activity |
MGI:MGI:1859999 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386195 |
F |
From MGI |
||
| GO:0004731 |
purine-nucleoside phosphorylase activity |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004731 |
purine-nucleoside phosphorylase activity |
MGI:MGI:3531253 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004731 |
purine-nucleoside phosphorylase activity |
MGI:MGI:3689284 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386195 |
F |
From MGI |
||
| GO:0004731 |
purine-nucleoside phosphorylase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004731 |
purine-nucleoside phosphorylase activity |
MGI:MGI:48978 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004731 |
purine-nucleoside phosphorylase activity |
MGI:MGI:49028 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3777967 |
F |
From MGI |
||
| GO:0004731 |
purine-nucleoside phosphorylase activity |
MGI:MGI:49059 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3777967 |
F |
From MGI |
||
| GO:0004731 |
purine-nucleoside phosphorylase activity |
MGI:MGI:49060 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3777975 |
F |
From MGI |
||
| GO:0004731 |
purine-nucleoside phosphorylase activity |
MGI:MGI:49348 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004731 |
purine-nucleoside phosphorylase activity |
MGI:MGI:54294 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004731 |
purine-nucleoside phosphorylase activity |
MGI:MGI:54302 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004731 |
purine-nucleoside phosphorylase activity |
MGI:MGI:54423 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004731 |
purine-nucleoside phosphorylase activity |
MGI:MGI:54603 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004731 |
purine-nucleoside phosphorylase activity |
MGI:MGI:55148 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004731 |
purine-nucleoside phosphorylase activity |
MGI:MGI:55561 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004731 |
purine-nucleoside phosphorylase activity |
MGI:MGI:56392 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004731 |
purine-nucleoside phosphorylase activity |
MGI:MGI:69194 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004731 |
purine-nucleoside phosphorylase activity |
MGI:MGI:69194 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3777967 |
F |
From MGI |
||
| GO:0004731 |
purine-nucleoside phosphorylase activity |
MGI:MGI:71610 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3777967 |
F |
From MGI |
||
| GO:0004731 |
purine-nucleoside phosphorylase activity |
MGI:MGI:86711 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3777967 |
F |
From MGI |
||
| GO:0005576 |
extracellular region |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:54603 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:55561 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:56392 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:69194 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005856 |
cytoskeleton |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0206 |
C |
From MGI |
||
| GO:0006139 |
nucleobase-containing compound metabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006148 |
inosine catabolic process |
MGI:MGI:1859999 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386195 |
P |
From MGI |
||
| GO:0006148 |
inosine catabolic process |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006148 |
inosine catabolic process |
MGI:MGI:3689284 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386195 |
P |
From MGI |
||
| GO:0006149 |
deoxyinosine catabolic process |
MGI:MGI:1859999 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386195 |
P |
From MGI |
||
| GO:0006161 |
deoxyguanosine catabolic process |
MGI:MGI:1859999 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386195 |
P |
From MGI |
||
| GO:0006183 |
GTP biosynthetic process |
MGI:MGI:1859999 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386195 |
P |
From MGI |
||
| GO:0006738 |
nicotinamide riboside catabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006955 |
immune response |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008144 |
drug binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0009116 |
nucleoside metabolic process |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0010332 |
response to gamma radiation |
MGI:MGI:1859999 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386195 |
P |
From MGI |
||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0016757 |
transferase activity, transferring glycosyl groups |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0328 |
F |
From MGI |
||
| GO:0016763 |
transferase activity, transferring pentosyl groups |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0034356 |
NAD biosynthesis via nicotinamide riboside salvage pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0034418 |
urate biosynthetic process |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0034418 |
urate biosynthetic process |
MGI:MGI:3689284 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386195 |
P |
From MGI |
||
| GO:0042102 |
positive regulation of T cell proliferation |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042102 |
positive regulation of T cell proliferation |
MGI:MGI:3689284 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386195 |
P |
From MGI |
||
| GO:0042102 |
positive regulation of T cell proliferation |
MGI:MGI:86711 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3777967 |
P |
From MGI |
||
| GO:0042278 |
purine nucleoside metabolic process |
MGI:MGI:3531253 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042278 |
purine nucleoside metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042278 |
purine nucleoside metabolic process |
MGI:MGI:49028 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3777967 |
P |
From MGI |
||
| GO:0042278 |
purine nucleoside metabolic process |
MGI:MGI:49059 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3777967 |
P |
From MGI |
||
| GO:0042278 |
purine nucleoside metabolic process |
MGI:MGI:49060 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3777975 |
P |
From MGI |
||
| GO:0042278 |
purine nucleoside metabolic process |
MGI:MGI:49348 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042278 |
purine nucleoside metabolic process |
MGI:MGI:54294 |
IC: Inferred by Curator |
GO:0004731 |
P |
From MGI |
||
| GO:0042278 |
purine nucleoside metabolic process |
MGI:MGI:54302 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042278 |
purine nucleoside metabolic process |
MGI:MGI:54603 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042278 |
purine nucleoside metabolic process |
MGI:MGI:55561 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042278 |
purine nucleoside metabolic process |
MGI:MGI:56392 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042278 |
purine nucleoside metabolic process |
MGI:MGI:69194 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042278 |
purine nucleoside metabolic process |
MGI:MGI:69194 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3777967 |
P |
From MGI |
||
| GO:0042278 |
purine nucleoside metabolic process |
MGI:MGI:71610 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3777967 |
P |
From MGI |
||
| GO:0042278 |
purine nucleoside metabolic process |
MGI:MGI:86711 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3777967 |
P |
From MGI |
||
| GO:0042301 |
phosphate ion binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042493 |
response to drug |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:1859999 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386195 |
P |
From MGI |
||
| GO:0045579 |
positive regulation of B cell differentiation |
MGI:MGI:1859999 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386195 |
P |
From MGI |
||
| GO:0045739 |
positive regulation of DNA repair |
MGI:MGI:1859999 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386195 |
P |
From MGI |
||
| GO:0046070 |
dGTP metabolic process |
MGI:MGI:1859999 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386195 |
P |
From MGI |
||
| GO:0046070 |
dGTP metabolic process |
MGI:MGI:86711 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3777968 |
P |
From MGI |
||
| GO:0046115 |
guanosine catabolic process |
MGI:MGI:1859999 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386195 |
P |
From MGI |
||
| GO:0046638 |
positive regulation of alpha-beta T cell differentiation |
MGI:MGI:1859999 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386195 |
P |
From MGI |
||
| GO:0046638 |
positive regulation of alpha-beta T cell differentiation |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046638 |
positive regulation of alpha-beta T cell differentiation |
MGI:MGI:3689284 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386195 |
P |
From MGI |
||
| GO:0046638 |
positive regulation of alpha-beta T cell differentiation |
MGI:MGI:86711 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3777967 |
P |
From MGI |
||
| GO:0070970 |
interleukin-2 secretion |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 Arpaia E et al. (2000) Mitochondrial basis for immune deficiency. Evidence from purine nucleoside phosphorylase-deficient mice. J Exp Med 191: 2197-208 PubMed GONUTS page
- ↑ 2.0 2.1 Blackburn MR et al. (1996) Metabolic and immunologic consequences of limited adenosine deaminase expression in mice. J Biol Chem 271: 15203-10 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Toro A & Grunebaum E (2006) TAT-mediated intracellular delivery of purine nucleoside phosphorylase corrects its deficiency in mice. J Clin Invest 116: 2717-26 PubMed GONUTS page
- ↑ Yasue M et al. (1991) Chromosomal assignments of 23 biochemical loci of the rat by using rat x mouse somatic cell hybrids. Cytogenet Cell Genet 57: 142-8 PubMed GONUTS page
- ↑ 5.0 5.1 Jenuth JP et al. (1991) Absence of dGTP accumulation and compensatory loss of deoxyguanosine kinase in purine nucleoside phosphorylase deficient mice. Adv Exp Med Biol 309B: 273-6 PubMed GONUTS page
- ↑ 6.0 6.1 Snyder FF (1991) Genetic models of purine nucleoside phosphorylase deficiency in the mouse. Adv Exp Med Biol 309B: 137-40 PubMed GONUTS page
- ↑ 7.0 7.1 Snyder FF & Mably ER (1991) Rescue of a lethal purine nucleoside phosphorylase mutation in the mouse via a second locus interaction. Adv Exp Med Biol 309B: 133-6 PubMed GONUTS page
- ↑ 8.0 8.1 Nelson DM et al. (1992) Isolation and expression of a murine purine nucleoside phosphorylase-encoding cDNA and sequence similarity with the human message. Gene 113: 215-21 PubMed GONUTS page
- ↑ 9.0 9.1 Kozak C et al. (1975) Gene linkage analysis in the mouse by somatic cell hybridization: assignment of adenine phosphoribosyltransferase to chromosome 8 and alpha-galactosidase to the X chromosome. Somatic Cell Genet 1: 371-82 PubMed GONUTS page
- ↑ 10.0 10.1 Womack JE et al. (1977) Mapping of nucleoside phosphorylase (Np-1) and esterase 10 (Es-10) on mouse chromosome 14. Biochem Genet 15: 347-55 PubMed GONUTS page
- ↑ Kozak CA & Ruddle FH (1977) Assignment of the genes for thymidine kinase and galactokinase to Mus musculus chromosome 11 and the preferential segregation of this chromosome in Chinese hamster/mouse somatic cell hybrids. Somatic Cell Genet 3: 121-33 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 Bremner TA et al. (1978) Nucleoside phosphorylase 2 (Np-2) of mice. Biochem Genet 16: 1143-51 PubMed GONUTS page
- ↑ Stallings RL & Siciliano MJ (1981) Confirmational, provisional, and/or regional assignment of 15 enzyme loci onto Chinese hamster autosomes 1, 2, and 7. Somatic Cell Genet 7: 683-98 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 Snyder FF et al. (1983) Genetic variability of purine nucleoside phosphorylase activity in the mouse: relationship to Np-1 and Np-2. Biochem Genet 21: 323-32 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 Lukey T et al. (1985) Purine nucleoside phosphorylase (Np) in the mouse: linkage relationship of Np-2 to esterase-10 (Es-10) and Np-1 on chromosome 14. Biochem Genet 23: 347-56 PubMed GONUTS page
- ↑ 16.0 16.1 16.2 16.3 16.4 Snyder FF et al. (1994) Secondary loss of deoxyguanosine kinase activity in purine nucleoside phosphorylase deficient mice. Biochim Biophys Acta 1227: 33-40 PubMed GONUTS page
- ↑ 17.0 17.1 Mably ER et al. (1989) Genetic deficiency of purine nucleoside phosphorylase in the mouse. Characterization of partially and severely enzyme deficient mutants. Genome 32: 1026-32 PubMed GONUTS page
- ↑ 18.0 18.1 18.2 18.3 18.4 Snyder FF et al. (1997) Point mutations at the purine nucleoside phosphorylase locus impair thymocyte differentiation in the mouse. Proc Natl Acad Sci U S A 94: 2522-7 PubMed GONUTS page
