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MGI:Pmaip1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Pmaip1 ( synonyms: Noxa ) | |
| Protein Name(s) | phorbol-12-myristate-13-acetate-induced protein 1, | |
| External Links | ||
| MGI | MGI:1930146 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001836 |
release of cytochrome c from mitochondria |
MGI:MGI:2675761 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2678372 |
P |
From MGI |
||
| GO:0001836 |
release of cytochrome c from mitochondria |
MGI:MGI:5009174 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0001844 |
protein insertion into mitochondrial membrane involved in induction of apoptosis |
MGI:MGI:2675761 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2678372 |
P |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:3689775 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3694305 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2679929 |
IMP: Inferred from Mutant Phenotype |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:1858284 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:2675761 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2678372 |
C |
From MGI |
||
| GO:0005739 |
mitochondrion |
MGI:MGI:2682130 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001008386 |
C |
From MGI |
||
| GO:0005739 |
mitochondrion |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006915 |
apoptotic process |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006917 |
induction of apoptosis |
MGI:MGI:1858284 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006917 |
induction of apoptosis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
MGI:MGI:5009174 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006921 |
cellular component disassembly involved in apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006926 |
virus-infected cell apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006974 |
response to DNA damage stimulus |
MGI:MGI:2675761 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2678372 |
P |
From MGI |
||
| GO:0008629 |
induction of apoptosis by intracellular signals |
MGI:MGI:2675761 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2678372 |
P |
From MGI |
||
| GO:0009411 |
response to UV |
MGI:MGI:2675761 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2678372 |
P |
From MGI |
||
| GO:0010165 |
response to X-ray |
MGI:MGI:2675761 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2678372 |
P |
From MGI |
||
| GO:0010498 |
proteasomal protein catabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010907 |
positive regulation of glucose metabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010917 |
negative regulation of mitochondrial membrane potential |
MGI:MGI:5009174 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:2675761 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2678372 |
C |
From MGI |
||
| GO:0032461 |
positive regulation of protein oligomerization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042149 |
cellular response to glucose starvation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042981 |
regulation of apoptotic process |
MGI:MGI:2665373 |
RCA: Inferred from Reviewed Computational Analysis |
P |
From MGI |
|||
| GO:0043029 |
T cell homeostasis |
MGI:MGI:3795821 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0043065 |
positive regulation of apoptotic process |
MGI:MGI:2679929 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2681649 |
P |
From MGI |
||
| GO:0043065 |
positive regulation of apoptotic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001008386 |
P |
From MGI |
||
| GO:0043065 |
positive regulation of apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043280 |
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043331 |
response to dsRNA |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043517 |
positive regulation of DNA damage response, signal transduction by p53 class mediator |
MGI:MGI:2679929 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0043517 |
positive regulation of DNA damage response, signal transduction by p53 class mediator |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043525 |
positive regulation of neuron apoptotic process |
MGI:MGI:3577145 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2678372 |
P |
From MGI |
||
| GO:0046902 |
regulation of mitochondrial membrane permeability |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048147 |
negative regulation of fibroblast proliferation |
MGI:MGI:2675761 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2678372 |
P |
From MGI |
||
| GO:0072332 |
signal transduction by p53 class mediator resulting in induction of apoptosis |
MGI:MGI:2679929 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0072332 |
signal transduction by p53 class mediator resulting in induction of apoptosis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0072593 |
reactive oxygen species metabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0090200 |
positive regulation of release of cytochrome c from mitochondria |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:2001244 |
positive regulation of intrinsic apoptotic signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Shibue T et al. (2003) Integral role of Noxa in p53-mediated apoptotic response. Genes Dev 17: 2233-8 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Kim JY et al. (2004) BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha. J Exp Med 199: 113-24 PubMed GONUTS page
- ↑ Chen L et al. (2005) Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell 17: 393-403 PubMed GONUTS page
- ↑ Certo M et al. (2006) Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell 9: 351-65 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Villunger A et al. (2003) p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 302: 1036-8 PubMed GONUTS page
- ↑ 6.0 6.1 Oda E et al. (2000) Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 288: 1053-8 PubMed GONUTS page
- ↑ Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115: 629-40 PubMed GONUTS page
- ↑ Reed JC et al. (2003) Comparative analysis of apoptosis and inflammation genes of mice and humans. Genome Res 13: 1376-88 PubMed GONUTS page
- ↑ Yamashita M et al. (2008) Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene. J Exp Med 205: 1109-20 PubMed GONUTS page
- ↑ Kiryu-Seo S et al. (2005) Noxa is a critical mediator of p53-dependent motor neuron death after nerve injury in adult mouse. J Neurosci 25: 1442-7 PubMed GONUTS page
