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MGI:Pkd1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Pkd1 ( synonyms: PC-1, PC1, polycystin-1 ) | |
| Protein Name(s) | polycystic kidney disease 1 homolog, | |
| External Links | ||
| MGI | MGI:97603 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001502 |
cartilage condensation |
MGI:MGI:2152028 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2152589 |
P |
From MGI |
||
| GO:0001568 |
blood vessel development |
MGI:MGI:1932572 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2183523 |
P |
From MGI |
||
| GO:0001701 |
in utero embryonic development |
MGI:MGI:3760608 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1197519 |
P |
From MGI |
||
| GO:0001701 |
in utero embryonic development |
MGI:MGI:3760608 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857562 |
P |
From MGI |
||
| GO:0001822 |
kidney development |
MGI:MGI:4836293 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0001892 |
embryonic placenta development |
MGI:MGI:4836293 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0002133 |
polycystin complex |
MGI:MGI:2180983 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005261 |
cation channel activity |
MGI:MGI:3573990 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005262 |
calcium channel activity |
MGI:MGI:2178492 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2178492 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2180983 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3573990 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001244281 |
C |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:3512725 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:5315699 |
IMP: Inferred from Mutant Phenotype |
C |
From MGI |
|||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001244281 |
C |
From MGI |
||
| GO:0005886 |
plasma membrane |
MGI:MGI:3573990 |
IPI: Inferred from Physical Interaction |
C |
From MGI |
|||
| GO:0005929 |
cilium |
MGI:MGI:2449360 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006611 |
protein export from nucleus |
MGI:MGI:4440396 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006816 |
calcium ion transport |
MGI:MGI:2449360 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857562 |
P |
From MGI |
||
| GO:0007050 |
cell cycle arrest |
MGI:MGI:2178492 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007218 |
neuropeptide signaling pathway |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007259 |
JAK-STAT cascade |
MGI:MGI:2178492 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007507 |
heart development |
MGI:MGI:2152028 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2152589 |
P |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0016323 |
basolateral plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016328 |
lateral plasma membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001244281 |
C |
From MGI |
||
| GO:0016337 |
cell-cell adhesion |
MGI:MGI:1932572 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2183523 |
P |
From MGI |
||
| GO:0018105 |
peptidyl-serine phosphorylation |
MGI:MGI:4440396 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0019901 |
protein kinase binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019904 |
protein domain specific binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030246 |
carbohydrate binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0031512 |
motile primary cilium |
MGI:MGI:3582145 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0031659 |
positive regulation of cyclin-dependent protein kinase activity involved in G1/S |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032092 |
positive regulation of protein binding |
MGI:MGI:5315699 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0042994 |
cytoplasmic sequestering of transcription factor |
MGI:MGI:5315699 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0042995 |
cell projection |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0966 |
C |
From MGI |
||
| GO:0044325 |
ion channel binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048754 |
branching morphogenesis of a tube |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050982 |
detection of mechanical stimulus |
MGI:MGI:2449360 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857562 |
P |
From MGI |
||
| GO:0050982 |
detection of mechanical stimulus |
MGI:MGI:3512725 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060674 |
placenta blood vessel development |
MGI:MGI:4836293 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Boulter C et al. (2001) Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene. Proc Natl Acad Sci U S A 98: 12174-9 PubMed GONUTS page
- ↑ 2.0 2.1 Kim K et al. (2000) Polycystin 1 is required for the structural integrity of blood vessels. Proc Natl Acad Sci U S A 97: 1731-6 PubMed GONUTS page
- ↑ 3.0 3.1 Hughes P et al. (2006) Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms. Cell Death Differ 13: 1123-7 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Garcia-Gonzalez MA et al. (2010) Pkd1 and Pkd2 are required for normal placental development. PLoS One 5: PubMed GONUTS page
- ↑ 5.0 5.1 Newby LJ et al. (2002) Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex. J Biol Chem 277: 20763-73 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Murakami M et al. (2005) Genomic organization and functional analysis of murine PKD2L1. J Biol Chem 280: 5626-35 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Bhunia AK et al. (2002) PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2. Cell 109: 157-68 PubMed GONUTS page
- ↑ 8.0 8.1 Chauvet V et al. (2004) Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus. J Clin Invest 114: 1433-43 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Li X et al. (2005) Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2. Nat Cell Biol 7: 1202-12 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Nauli SM et al. (2003) Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet 33: 129-37 PubMed GONUTS page
- ↑ 11.0 11.1 Xia S et al. (2010) Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts. Development 137: 1075-84 PubMed GONUTS page
- ↑ Teilmann SC et al. (2005) Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs. Mol Reprod Dev 71: 444-52 PubMed GONUTS page
