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MGI:Pitx3
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Pitx3 ( synonyms: Ptx3 ) | |
| Protein Name(s) | paired-like homeodomain transcription factor 3, | |
| External Links | ||
| MGI | MGI:1100498 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0002088 |
lens development in camera-type eye |
MGI:MGI:3831639 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0002088 |
lens development in camera-type eye |
MGI:MGI:4353482 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0002089 |
lens morphogenesis in camera-type eye |
MGI:MGI:4353482 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0238 |
F |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3830409 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4887332 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:4887332 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0217 |
P |
From MGI |
||
| GO:0007626 |
locomotory behavior |
MGI:MGI:3759093 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856667 |
P |
From MGI |
||
| GO:0010468 |
regulation of gene expression |
MGI:MGI:3757895 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030901 |
midbrain development |
MGI:MGI:3035846 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856667 |
P |
From MGI |
||
| GO:0030901 |
midbrain development |
MGI:MGI:3582099 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030901 |
midbrain development |
MGI:MGI:3759093 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856667 |
P |
From MGI |
||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:3830409 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048666 |
neuron development |
MGI:MGI:3035846 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856667 |
P |
From MGI |
||
| GO:0070306 |
lens fiber cell differentiation |
MGI:MGI:3831639 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0071542 |
dopaminergic neuron differentiation |
MGI:MGI:3582099 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0071542 |
dopaminergic neuron differentiation |
MGI:MGI:3830409 |
IDA: Inferred from Direct Assay |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Ho HY et al. (2009) Homeodomain protein Pitx3 maintains the mitotic activity of lens epithelial cells. Mech Dev 126: 18-29 PubMed GONUTS page
- ↑ 2.0 2.1 Medina-Martinez O et al. (2009) Pitx3 controls multiple aspects of lens development. Dev Dyn 238: 2193-201 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Jacobs FM et al. (2009) Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression. Development 136: 531-40 PubMed GONUTS page
- ↑ 4.0 4.1 Messmer K et al. (2007) Induction of tyrosine hydroxylase expression by the transcription factor Pitx3. Int J Dev Neurosci 25: 29-37 PubMed GONUTS page
- ↑ 5.0 5.1 Kas MJ et al. (2008) Phenotypic segregation of aphakia and Pitx3-null mutants reveals that Pitx3 deficiency increases consolidation of specific movement components. Behav Brain Res 186: 208-14 PubMed GONUTS page
- ↑ Kim J et al. (2007) A MicroRNA feedback circuit in midbrain dopamine neurons. Science 317: 1220-4 PubMed GONUTS page
- ↑ 7.0 7.1 Smidt MP et al. (2004) Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3. Development 131: 1145-55 PubMed GONUTS page
- ↑ 8.0 8.1 Maxwell SL et al. (2005) Pitx3 regulates tyrosine hydroxylase expression in the substantia nigra and identifies a subgroup of mesencephalic dopaminergic progenitor neurons during mouse development. Dev Biol 282: 467-79 PubMed GONUTS page
