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MGI:Pias4
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Pias4 ( synonyms: PIASy ) | |
| Protein Name(s) | protein inhibitor of activated STAT 4, | |
| External Links | ||
| MGI | MGI:2136940 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:2154657 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4887534 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0003676 |
nucleic acid binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:2154657 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003714 |
transcription corepressor activity |
MGI:MGI:1861161 |
ISA: Inferred from Sequence Alignment |
EMBL:AF077950 |
F |
From MGI |
||
| GO:0003714 |
transcription corepressor activity |
MGI:MGI:2154657 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2154657 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3663197 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:1861161 |
ISA: Inferred from Sequence Alignment |
EMBL:AF077950 |
C |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:2154657 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0805 |
P |
From MGI |
||
| GO:0007259 |
JAK-STAT cascade |
MGI:MGI:1861161 |
ISA: Inferred from Sequence Alignment |
EMBL:AF077950 |
P |
From MGI |
||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:1861161 |
NAS: Non-traceable Author Statement |
P |
From MGI |
|||
| GO:0008270 |
zinc ion binding |
MGI:MGI:1861161 |
NAS: Non-traceable Author Statement |
F |
From MGI |
|||
| GO:0016055 |
Wnt receptor signaling pathway |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0879 |
P |
From MGI |
||
| GO:0016363 |
nuclear matrix |
MGI:MGI:2154657 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016874 |
ligase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0436 |
F |
From MGI |
||
| GO:0016925 |
protein sumoylation |
MGI:MGI:2154657 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0016925 |
protein sumoylation |
MGI:MGI:4887534 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0019789 |
SUMO ligase activity |
MGI:MGI:2154657 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0019789 |
SUMO ligase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0031625 |
ubiquitin protein ligase binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0031625 |
ubiquitin protein ligase binding |
MGI:MGI:5009403 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0032088 |
negative regulation of NF-kappaB transcription factor activity |
MGI:MGI:5009403 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0033235 |
positive regulation of protein sumoylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043065 |
positive regulation of apoptotic process |
MGI:MGI:5009403 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0044419 |
interspecies interaction between organisms |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0945 |
P |
From MGI |
||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:2001141 |
regulation of RNA biosynthetic process |
MGI:MGI:1861161 |
ISA: Inferred from Sequence Alignment |
EMBL:AF077950 |
P |
From MGI |
||
|
contributes_to |
GO:0019789 |
SUMO ligase activity |
MGI:MGI:4887534 |
IDA: Inferred from Direct Assay |
F |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Sachdev S et al. (2001) PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies. Genes Dev 15: 3088-103 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Pourcet B et al. (2010) SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR. J Biol Chem 285: 5983-92 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Sturm S et al. (2000) Cloning and analysis of a murine PIAS family member, PIASgamma, in developing skin and neurons. J Mol Neurosci 14: 107-21 PubMed GONUTS page
- ↑ Prigge JR & Schmidt EE (2006) Interaction of protein inhibitor of activated STAT (PIAS) proteins with the TATA-binding protein, TBP. J Biol Chem 281: 12260-9 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Albor A et al. (2006) The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through NFkappaB. J Biol Chem 281: 25850-66 PubMed GONUTS page
