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MGI:Phox2b
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Phox2b ( synonyms: Dilp1, GENA 269, NBPhox, Phox2b, Pmx2b ) | |
| Protein Name(s) | paired-like homeobox 2b, | |
| External Links | ||
| MGI | MGI:1100882 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000790 |
nuclear chromatin |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0000977 |
RNA polymerase II regulatory region sequence-specific DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0001764 |
neuron migration |
MGI:MGI:3761765 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3521828 |
P |
From MGI |
||
| GO:0003357 |
noradrenergic neuron differentiation |
MGI:MGI:4849589 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:4418265 |
P |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0238 |
F |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1290114 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1346238 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3703127 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0217 |
P |
From MGI |
||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:3797655 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926861 |
P |
From MGI |
||
| GO:0010001 |
glial cell differentiation |
MGI:MGI:3797655 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926861 |
P |
From MGI |
||
| GO:0021533 |
cell differentiation in hindbrain |
MGI:MGI:3767119 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926861 |
P |
From MGI |
||
| GO:0021934 |
hindbrain tangential cell migration |
MGI:MGI:4849589 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:4418265 |
P |
From MGI |
||
| GO:0030182 |
neuron differentiation |
MGI:MGI:3797655 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926861 |
P |
From MGI |
||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0045665 |
negative regulation of neuron differentiation |
MGI:MGI:3767119 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1100882 |
P |
From MGI |
||
| GO:0045666 |
positive regulation of neuron differentiation |
MGI:MGI:3767119 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1100882 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048468 |
cell development |
MGI:MGI:3530939 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926861 |
P |
From MGI |
||
| GO:0048839 |
inner ear development |
MGI:MGI:3621705 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926861 |
P |
From MGI |
||
| GO:0048894 |
efferent axon development in a lateral line nerve |
MGI:MGI:3621705 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926861 |
P |
From MGI |
||
| GO:0071773 |
cellular response to BMP stimulus |
MGI:MGI:4366654 |
IDA: Inferred from Direct Assay |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Coppola E et al. (2005) Reciprocal gene replacements reveal unique functions for Phox2 genes during neural differentiation. EMBO J 24: 4392-403 PubMed GONUTS page
- ↑ 2.0 2.1 Coppola E et al. (2010) Ongoing roles of Phox2 homeodomain transcription factors during neuronal differentiation. Development 137: 4211-20 PubMed GONUTS page
- ↑ Young HM et al. (1998) A single rostrocaudal colonization of the rodent intestine by enteric neuron precursors is revealed by the expression of Phox2b, Ret, and p75 and by explants grown under the kidney capsule or in organ culture. Dev Biol 202: 67-84 PubMed GONUTS page
- ↑ Young HM et al. (1999) Expression of Ret-, p75(NTR)-, Phox2a-, Phox2b-, and tyrosine hydroxylase-immunoreactivity by undifferentiated neural crest-derived cells and different classes of enteric neurons in the embryonic mouse gut. Dev Dyn 216: 137-52 PubMed GONUTS page
- ↑ Bates MD et al. (2006) The Hlx homeobox transcription factor is required early in enteric nervous system development. BMC Dev Biol 6: 33 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Nekrep N et al. (2008) Signals from the neural crest regulate beta-cell mass in the pancreas. Development 135: 2151-60 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Jacob J et al. (2007) Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis. Nat Neurosci 10: 1433-9 PubMed GONUTS page
- ↑ Huber K et al. (2005) The role of Phox2B in chromaffin cell development. Dev Biol 279: 501-8 PubMed GONUTS page
- ↑ 9.0 9.1 Tiveron MC et al. (2003) Role of Phox2b and Mash1 in the generation of the vestibular efferent nucleus. Dev Biol 260: 46-57 PubMed GONUTS page
- ↑ Morikawa Y et al. (2009) BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways. Development 136: 3575-84 PubMed GONUTS page
