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MGI:Pex5
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Pex5 ( synonyms: ESTM1, peroxisome biogenesis factor 5, PTS1R, Pxr1 ) | |
| Protein Name(s) | peroxisomal biogenesis factor 5, | |
| External Links | ||
| MGI | MGI:1098808 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000038 |
very long-chain fatty acid metabolic process |
MGI:MGI:1352371 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154454 |
P |
From MGI |
||
| GO:0000268 |
peroxisome targeting sequence binding |
MGI:MGI:2157179 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0001764 |
neuron migration |
MGI:MGI:1096198 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154454 |
P |
From MGI |
||
| GO:0001764 |
neuron migration |
MGI:MGI:1352371 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154454 |
P |
From MGI |
||
| GO:0001764 |
neuron migration |
MGI:MGI:2679784 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154454 |
P |
From MGI |
||
| GO:0005052 |
peroxisome matrix targeting signal-1 binding |
MGI:MGI:4441152 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From MGI |
|||
| GO:0005052 |
peroxisome matrix targeting signal-1 binding |
MGI:MGI:4459044 |
PANTHER:PTHR10130 |
F |
From MGI |
|||
| GO:0005052 |
peroxisome matrix targeting signal-1 binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2157179 |
TAS: Traceable Author Statement |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:4441152 |
ISS: Inferred from Sequence or Structural Similarity |
C |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001164055 |
C |
From MGI |
||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:2151292 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154454 |
C |
From MGI |
||
| GO:0005777 |
peroxisome |
MGI:MGI:2158861 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005777 |
peroxisome |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001164055 |
C |
From MGI |
||
| GO:0005777 |
peroxisome |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005778 |
peroxisomal membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001164055 |
C |
From MGI |
||
| GO:0005778 |
peroxisomal membrane |
MGI:MGI:4459044 |
PANTHER:PTHR10130 |
C |
From MGI |
|||
| GO:0005782 |
peroxisomal matrix |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001164055 |
C |
From MGI |
||
| GO:0005829 |
cytosol |
MGI:MGI:4459044 |
PANTHER:PTHR10130 |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006625 |
protein targeting to peroxisome |
MGI:MGI:2157179 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0006625 |
protein targeting to peroxisome |
MGI:MGI:4441152 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From MGI |
|||
| GO:0006625 |
protein targeting to peroxisome |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006635 |
fatty acid beta-oxidation |
MGI:MGI:1096198 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154454 |
P |
From MGI |
||
| GO:0006635 |
fatty acid beta-oxidation |
MGI:MGI:3711634 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2384516 |
P |
From MGI |
||
| GO:0006810 |
transport |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0813 |
P |
From MGI |
||
| GO:0007005 |
mitochondrion organization |
MGI:MGI:3656427 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2384516 |
P |
From MGI |
||
| GO:0007006 |
mitochondrial membrane organization |
MGI:MGI:2151292 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154454 |
P |
From MGI |
||
| GO:0007029 |
endoplasmic reticulum organization |
MGI:MGI:3656427 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2384516 |
P |
From MGI |
||
| GO:0007031 |
peroxisome organization |
MGI:MGI:1096198 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154454 |
P |
From MGI |
||
| GO:0007031 |
peroxisome organization |
MGI:MGI:2679784 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007031 |
peroxisome organization |
MGI:MGI:3656427 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2384516 |
P |
From MGI |
||
| GO:0008022 |
protein C-terminus binding |
MGI:MGI:4441152 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From MGI |
|||
| GO:0008022 |
protein C-terminus binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0015031 |
protein transport |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0653 |
P |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016558 |
protein import into peroxisome matrix |
MGI:MGI:4459044 |
PANTHER:PTHR10130 |
P |
From MGI |
|||
| GO:0016561 |
protein import into peroxisome matrix, translocation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0021795 |
cerebral cortex cell migration |
MGI:MGI:1096198 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154454 |
P |
From MGI |
||
| GO:0021795 |
cerebral cortex cell migration |
MGI:MGI:1352371 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154454 |
P |
From MGI |
||
| GO:0021895 |
cerebral cortex neuron differentiation |
MGI:MGI:1096198 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154454 |
P |
From MGI |
||
| GO:0040018 |
positive regulation of multicellular organism growth |
MGI:MGI:1096198 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154454 |
P |
From MGI |
||
| GO:0040018 |
positive regulation of multicellular organism growth |
MGI:MGI:1352371 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154454 |
P |
From MGI |
||
| GO:0043234 |
protein complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001164055 |
C |
From MGI |
||
| GO:0044255 |
cellular lipid metabolic process |
MGI:MGI:3623834 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2384516 |
P |
From MGI |
||
| GO:0047485 |
protein N-terminus binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0048468 |
cell development |
MGI:MGI:1096198 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154454 |
P |
From MGI |
||
| GO:0050905 |
neuromuscular process |
MGI:MGI:1096198 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154454 |
P |
From MGI |
||
| GO:0051262 |
protein tetramerization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
|
NOT |
GO:0008299 |
isoprenoid biosynthetic process |
MGI:MGI:2136720 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154454 |
P |
From MGI |
|
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Janssen A et al. (2000) Docosahexaenoic acid deficit is not a major pathogenic factor in peroxisome-deficient mice. Lab Invest 80: 31-5 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Hogenboom S et al. (2002) Absence of functional peroxisomes does not lead to deficiency of enzymes involved in cholesterol biosynthesis. J Lipid Res 43: 90-8 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Baes M et al. (1997) A mouse model for Zellweger syndrome. Nat Genet 17: 49-57 PubMed GONUTS page
- ↑ 4.0 4.1 Janssen A et al. (2003) Neuronal migration depends on intact peroxisomal function in brain and in extraneuronal tissues. J Neurosci 23: 9732-41 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Braverman N et al. (1998) An isoform of pex5p, the human PTS1 receptor, is required for the import of PTS2 proteins into peroxisomes. Hum Mol Genet 7: 1195-205 PubMed GONUTS page
- ↑ 6.0 6.1 Baumgart E et al. (2001) Mitochondrial alterations caused by defective peroxisomal biogenesis in a mouse model for Zellweger syndrome (PEX5 knockout mouse). Am J Pathol 159: 1477-94 PubMed GONUTS page
- ↑ Björkman J et al. (2002) Pex13, the mouse ortholog of the human peroxisome biogenesis disorder PEX13 gene: gene structure, tissue expression, and localization of the protein to peroxisomes. Genomics 79: 162-8 PubMed GONUTS page
- ↑ Dirkx R et al. (2007) Beta-oxidation in hepatocyte cultures from mice with peroxisomal gene knockouts. Biochem Biophys Res Commun 357: 718-23 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Dirkx R et al. (2005) Absence of peroxisomes in mouse hepatocytes causes mitochondrial and ER abnormalities. Hepatology 41: 868-78 PubMed GONUTS page
- ↑ Huyghe S et al. (2006) Peroxisomal multifunctional protein 2 is essential for lipid homeostasis in Sertoli cells and male fertility in mice. Endocrinology 147: 2228-36 PubMed GONUTS page
- ↑ Vanhorebeek I et al. (2001) Isoprenoid biosynthesis is not compromised in a Zellweger syndrome mouse model. Biochim Biophys Acta 1532: 28-36 PubMed GONUTS page
