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MGI:Pecam1

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Pecam1 ( synonyms: Cd31, PECAM-1 )
Protein Name(s) platelet/endothelial cell adhesion molecule 1,
External Links
MGI MGI:97537

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0002687

positive regulation of leukocyte migration

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_113779

P

From MGI

GO:0005515

protein binding

MGI:MGI:1933047
PMID:11254359[1]

IPI: Inferred from Physical Interaction

UniProtKB:P42227
UniProtKB:Q6PHA0

F

From MGI

GO:0005615

extracellular space

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P16284

C

From MGI

GO:0005622

intracellular

MGI:MGI:2669063
PMID:12890700[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2677448

C

From MGI

GO:0005625

soluble fraction

MGI:MGI:3759000
PMID:17717145[3]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:2665265
PMID:12736726[4]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:3607039
PMID:16251442[5]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P16284

C

From MGI

GO:0006909

phagocytosis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P16284

P

From MGI

GO:0006928

cellular component movement

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_113779

P

From MGI

GO:0007155

cell adhesion

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0130

P

From MGI

GO:0007266

Rho protein signal transduction

MGI:MGI:2669063
PMID:12890700[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2677448

P

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:4820887
PMID:20620994[6]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:5052199
PMID:21708977[7]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009986

cell surface

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_113779

C

From MGI

GO:0016020

membrane

MGI:MGI:3640953
PMID:16691571[8]

IDA: Inferred from Direct Assay

C

From MGI

GO:0016021

integral to membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

From MGI

GO:0030054

cell junction

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0965

C

From MGI

GO:0030334

regulation of cell migration

MGI:MGI:2669063
PMID:12890700[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2677448

P

From MGI

GO:0030485

smooth muscle contractile fiber

MGI:MGI:3794929
PMID:18332105[9]

IDA: Inferred from Direct Assay

C

From MGI

GO:0042060

wound healing

MGI:MGI:2669063
PMID:12890700[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2677448

P

From MGI

GO:0042523

positive regulation of tyrosine phosphorylation of Stat5 protein

MGI:MGI:1933047
PMID:11254359[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045121

membrane raft

MGI:MGI:2669063
PMID:12890700[2]

IDA: Inferred from Direct Assay

C

From MGI

GO:0050904

diapedesis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P16284

P

From MGI

GO:0071944

cell periphery

MGI:MGI:4949803
PMID:21464233[10]

IDA: Inferred from Direct Assay

C

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 Ilan N et al. (2001) Pecam-1 is a modulator of stat family member phosphorylation and localization: lessons from a transgenic mouse. Dev Biol 232: 219-32 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 Gratzinger D et al. (2003) Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho. FASEB J 17: 1458-69 PubMed GONUTS page
  3. Zhang H et al. (2007) Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice. Am J Pathol 171: 1113-26 PubMed GONUTS page
  4. Wakayama T et al. (2003) The expression of platelet endothelial cell adhesion molecule-1 in mouse primordial germ cells during their migration and early gonadal formation. Histochem Cell Biol 119: 355-62 PubMed GONUTS page
  5. Proctor JM et al. (2005) Vascular development of the brain requires beta8 integrin expression in the neuroepithelium. J Neurosci 25: 9940-8 PubMed GONUTS page
  6. Davies BS et al. (2010) GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries. Cell Metab 12: 42-52 PubMed GONUTS page
  7. Crippa S et al. (2011) miR669a and miR669q prevent skeletal muscle differentiation in postnatal cardiac progenitors. J Cell Biol 193: 1197-212 PubMed GONUTS page
  8. Moreno-Barriuso N et al. (2006) Alterations in alveolar epithelium differentiation and vasculogenesis in lungs of LIF/IGF-I double deficient embryos. Dev Dyn 235: 2040-50 PubMed GONUTS page
  9. Ogata T et al. (2008) MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance. Mol Cell Biol 28: 3424-36 PubMed GONUTS page
  10. Osorio KM et al. (2011) Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments. J Cell Biol 193: 235-50 PubMed GONUTS page
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