MGI:Pdx1

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:3697248 PMID:17056599^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0001046	core promoter sequence-specific DNA binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P52947	F	From MGI
	GO:0001889	liver development	MGI:MGI:4355651 PMID:19619492^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2388676	P	From MGI
	GO:0003309	type B pancreatic cell differentiation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P52947	P	From MGI
	GO:0003309	type B pancreatic cell differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P52945	P	From MGI
	GO:0003677	DNA binding	MGI:MGI:2447494 PMID:12368292^[3]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003677	DNA binding	MGI:MGI:2676531 PMID:12972592^[4]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003677	DNA binding	MGI:MGI:3615098 PMID:15486225^[5]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003677	DNA binding	MGI:MGI:3697248 PMID:17056599^[1]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003682	chromatin binding	MGI:MGI:4366217 PMID:19651901^[6]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:3615098 PMID:15486225^[5]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P52947	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3697248 PMID:17056599^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q60954-1	F	From MGI
	GO:0005634	nucleus	MGI:MGI:2447254 PMID:12488434^[7]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:2686820 PMID:14702043^[8]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3581949 PMID:15888377^[9]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3615098 PMID:15486225^[5]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3771560 PMID:18155690^[10]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P52947	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P52947	C	From MGI
	GO:0006006	glucose metabolic process	MGI:MGI:2670470 PMID:12904469^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006351	transcription, DNA-dependent	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P52947	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0805	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR017995 InterPro:IPR017970 InterPro:IPR001356	P	From MGI
	GO:0006357	regulation of transcription from RNA polymerase II promoter	MGI:MGI:2676531 PMID:12972592^[4]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0006357	regulation of transcription from RNA polymerase II promoter	MGI:MGI:3037232 PMID:14701942^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006366	transcription from RNA polymerase II promoter	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P52947	P	From MGI
	GO:0007224	smoothened signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P52947	P	From MGI
	GO:0007263	nitric oxide mediated signal transduction	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P52945	P	From MGI
	GO:0007275	multicellular organismal development	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0217	P	From MGI
	GO:0008134	transcription factor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P52947	F	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:3771560 PMID:18155690^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2181360	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P52947	P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:3771560 PMID:18155690^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2181360	P	From MGI
	GO:0009749	response to glucose stimulus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P52947	P	From MGI
	GO:0010942	positive regulation of cell death	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P52947	P	From MGI
	GO:0016331	morphogenesis of embryonic epithelium	MGI:MGI:80614 PMID:8625829^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2152755	P	From MGI
	GO:0030073	insulin secretion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P52945	P	From MGI
	GO:0030154	cell differentiation	MGI:MGI:3612374 PMID:16418487^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2181362	P	From MGI
	GO:0030154	cell differentiation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P52947	P	From MGI
	GO:0031016	pancreas development	MGI:MGI:3612374 PMID:16418487^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2181362	P	From MGI
	GO:0031016	pancreas development	MGI:MGI:80614 PMID:8625829^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2152755	P	From MGI
	GO:0031017	exocrine pancreas development	MGI:MGI:3610256 PMID:16126192^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2388676	P	From MGI
	GO:0031018	endocrine pancreas development	MGI:MGI:3771560 PMID:18155690^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2181360	P	From MGI
	GO:0032024	positive regulation of insulin secretion	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P52947	P	From MGI
	GO:0032403	protein complex binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P52947	F	From MGI
	GO:0042127	regulation of cell proliferation	MGI:MGI:2447254 PMID:12488434^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0042593	glucose homeostasis	MGI:MGI:3771560 PMID:18155690^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2181360	P	From MGI
	GO:0042593	glucose homeostasis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P52947	P	From MGI
	GO:0043388	positive regulation of DNA binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P52947	P	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:3037232 PMID:14701942^[12]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P52947	F	From MGI
	GO:0044424	intracellular part	MGI:MGI:3614320 PMID:15793245^[16]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0044424	intracellular part	MGI:MGI:3706893 PMID:10868931^[17]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0045892	negative regulation of transcription, DNA-dependent	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P52947	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:2447494 PMID:12368292^[3]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P52947	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3037232 PMID:14701942^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3615098 PMID:15486225^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P52947	P	From MGI
	GO:0046982	protein heterodimerization activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P52947	F	From MGI
	GO:0048565	digestive tract development	MGI:MGI:4355651 PMID:19619492^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2388676	P	From MGI
	GO:0048863	stem cell differentiation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P52947	P	From MGI
	GO:0051594	detection of glucose	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P52947	P	From MGI
colocalizes_with	GO:0005737	cytoplasm	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P52947	C	From MGI
contributes_to	GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P52947	F	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Deramaudt TB et al. (2006) The PDX1 homeodomain transcription factor negatively regulates the pancreatic ductal cell-specific keratin 19 promoter. J Biol Chem 281: 38385-95 PubMed GONUTS page
↑ ^2.0 ^2.1 Spence JR et al. (2009) Sox17 regulates organ lineage segregation of ventral foregut progenitor cells. Dev Cell 17: 62-74 PubMed GONUTS page
↑ ^3.0 ^3.1 Kataoka K et al. (2002) MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene. J Biol Chem 277: 49903-10 PubMed GONUTS page
↑ ^4.0 ^4.1 Annicotte JS et al. (2003) Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development. Mol Cell Biol 23: 6713-24 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Jepeal LI et al. (2005) Cell-specific expression of glucose-dependent-insulinotropic polypeptide is regulated by the transcription factor PDX-1. Endocrinology 146: 383-91 PubMed GONUTS page
↑ Ueda T et al. (2009) The nucleosome binding protein HMGN3 modulates the transcription profile of pancreatic beta cells and affects insulin secretion. Mol Cell Biol 29: 5264-76 PubMed GONUTS page
↑ ^7.0 ^7.1 Kitamura T et al. (2002) The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest 110: 1839-47 PubMed GONUTS page
↑ Sumazaki R et al. (2004) Conversion of biliary system to pancreatic tissue in Hes1-deficient mice. Nat Genet 36: 83-7 PubMed GONUTS page
↑ Rosanas-Urgell A et al. (2005) Pdx1-related homeodomain transcription factors are distinctly expressed in mouse adult pancreatic islets. Mol Cell Endocrinol 237: 59-66 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Gannon M et al. (2008) pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev Biol 314: 406-17 PubMed GONUTS page
↑ Schubert M et al. (2003) Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci 23: 7084-92 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Gerrish K et al. (2004) Conserved transcriptional regulatory domains of the pdx-1 gene. Mol Endocrinol 18: 533-48 PubMed GONUTS page
↑ ^13.0 ^13.1 Ahlgren U et al. (1996) The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice. Development 122: 1409-16 PubMed GONUTS page
↑ ^14.0 ^14.1 Fujitani Y et al. (2006) Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. Genes Dev 20: 253-66 PubMed GONUTS page
↑ Hale MA et al. (2005) The homeodomain protein PDX1 is required at mid-pancreatic development for the formation of the exocrine pancreas. Dev Biol 286: 225-37 PubMed GONUTS page
↑ Chu K & Tsai MJ (2005) Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion. Diabetes 54: 1064-73 PubMed GONUTS page
↑ Jensen J et al. (2000) Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation. Diabetes 49: 163-76 PubMed GONUTS page

[PMID:17056599-0] 1.0 ^1.1 ^1.2 Deramaudt TB et al. (2006) The PDX1 homeodomain transcription factor negatively regulates the pancreatic ductal cell-specific keratin 19 promoter. J Biol Chem 281: 38385-95 PubMed GONUTS page

[PMID:19619492-1] 2.0 ^2.1 Spence JR et al. (2009) Sox17 regulates organ lineage segregation of ventral foregut progenitor cells. Dev Cell 17: 62-74 PubMed GONUTS page

[PMID:12368292-2] 3.0 ^3.1 Kataoka K et al. (2002) MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene. J Biol Chem 277: 49903-10 PubMed GONUTS page

[PMID:12972592-3] 4.0 ^4.1 Annicotte JS et al. (2003) Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development. Mol Cell Biol 23: 6713-24 PubMed GONUTS page

[PMID:15486225-4] 5.0 ^5.1 ^5.2 ^5.3 Jepeal LI et al. (2005) Cell-specific expression of glucose-dependent-insulinotropic polypeptide is regulated by the transcription factor PDX-1. Endocrinology 146: 383-91 PubMed GONUTS page

[PMID:19651901-5] Ueda T et al. (2009) The nucleosome binding protein HMGN3 modulates the transcription profile of pancreatic beta cells and affects insulin secretion. Mol Cell Biol 29: 5264-76 PubMed GONUTS page

[PMID:12488434-6] 7.0 ^7.1 Kitamura T et al. (2002) The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest 110: 1839-47 PubMed GONUTS page

[PMID:14702043-7] Sumazaki R et al. (2004) Conversion of biliary system to pancreatic tissue in Hes1-deficient mice. Nat Genet 36: 83-7 PubMed GONUTS page

[PMID:15888377-8] Rosanas-Urgell A et al. (2005) Pdx1-related homeodomain transcription factors are distinctly expressed in mouse adult pancreatic islets. Mol Cell Endocrinol 237: 59-66 PubMed GONUTS page

[PMID:18155690-9] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Gannon M et al. (2008) pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev Biol 314: 406-17 PubMed GONUTS page

[PMID:12904469-10] Schubert M et al. (2003) Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci 23: 7084-92 PubMed GONUTS page

[PMID:14701942-11] 12.0 ^12.1 ^12.2 Gerrish K et al. (2004) Conserved transcriptional regulatory domains of the pdx-1 gene. Mol Endocrinol 18: 533-48 PubMed GONUTS page

[PMID:8625829-12] 13.0 ^13.1 Ahlgren U et al. (1996) The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice. Development 122: 1409-16 PubMed GONUTS page

[PMID:16418487-13] 14.0 ^14.1 Fujitani Y et al. (2006) Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. Genes Dev 20: 253-66 PubMed GONUTS page

[PMID:16126192-14] Hale MA et al. (2005) The homeodomain protein PDX1 is required at mid-pancreatic development for the formation of the exocrine pancreas. Dev Biol 286: 225-37 PubMed GONUTS page

[PMID:15793245-15] Chu K & Tsai MJ (2005) Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion. Diabetes 54: 1064-73 PubMed GONUTS page

[PMID:10868931-16] Jensen J et al. (2000) Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation. Diabetes 49: 163-76 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Pdx1 ( synonyms: IDX-1, IPF-1, Ipf1, Mody4, pdx-1, STF-1 )
Protein Name(s)	pancreatic and duodenal homeobox 1,
External Links
MGI	MGI:102851

MGI:Pdx1

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