MGI:Pdgfrb

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000166	nucleotide binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0547	F	From MGI
	GO:0001701	in utero embryonic development	MGI:MGI:3696608 PMID:17143286^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135508	P	From MGI
	GO:0001822	kidney development	MGI:MGI:3696608 PMID:17143286^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135508	P	From MGI
	GO:0001894	tissue homeostasis	MGI:MGI:3696608 PMID:17143286^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135508	P	From MGI
	GO:0004672	protein kinase activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000719 InterPro:IPR001245	F	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q05030	F	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09619	F	From MGI
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	MGI:MGI:2152096	IEA: Inferred from Electronic Annotation	EC:2.7.10.1	F	From MGI
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR016243 InterPro:IPR001824	F	From MGI
	GO:0004871	signal transducer activity	MGI:MGI:2182234 PMID:11940581^[2]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004872	receptor activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0675	F	From MGI
	GO:0005017	platelet-derived growth factor-activated receptor activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q05030	F	From MGI
	GO:0005019	platelet-derived growth factor beta-receptor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09619	F	From MGI
	GO:0005021	vascular endothelial growth factor-activated receptor activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR009134	F	From MGI
	GO:0005102	receptor binding	MGI:MGI:3617099 PMID:16456542^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P05622	F	From MGI
	GO:0005102	receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09619	F	From MGI
	GO:0005161	platelet-derived growth factor receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09619	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3617099 PMID:16456542^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P05622 UniProtKB:Q9JHL1	F	From MGI
	GO:0005515	protein binding	MGI:MGI:5009204 PMID:10644978^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P26450 UniProtKB:Q91ZM2	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0067	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000719 InterPro:IPR017441 InterPro:IPR016243 InterPro:IPR001824 InterPro:IPR009134	F	From MGI
	GO:0005634	nucleus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q05030	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q05030	C	From MGI
	GO:0005764	lysosome	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0458	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q05030	C	From MGI
	GO:0005887	integral to plasma membrane	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR009134	C	From MGI
	GO:0006024	glycosaminoglycan biosynthetic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q05030	P	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR020635 InterPro:IPR016243 InterPro:IPR001824 InterPro:IPR009134	P	From MGI
	GO:0006807	nitrogen compound metabolic process	MGI:MGI:3696608 PMID:17143286^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135508	P	From MGI
	GO:0006935	chemotaxis	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0145	P	From MGI
	GO:0007165	signal transduction	MGI:MGI:2182234 PMID:11940581^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007165	signal transduction	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09619	P	From MGI
	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR016243 InterPro:IPR001824	P	From MGI
	GO:0007179	transforming growth factor beta receptor signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q05030	P	From MGI
	GO:0007243	intracellular protein kinase cascade	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q05030	P	From MGI
	GO:0007275	multicellular organismal development	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0217	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q05030	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09619	P	From MGI
	GO:0010863	positive regulation of phospholipase C activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09619	P	From MGI
	GO:0014068	positive regulation of phosphatidylinositol 3-kinase cascade	MGI:MGI:5009390 PMID:17942966^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0014911	positive regulation of smooth muscle cell migration	MGI:MGI:1338343 PMID:10375497^[6]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0014911	positive regulation of smooth muscle cell migration	MGI:MGI:4365879 PMID:19742316^[7]	IGI: Inferred from Genetic Interaction	UniProtKB:Q91ZX7	P	From MGI
	GO:0014911	positive regulation of smooth muscle cell migration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09619	P	From MGI
	GO:0016020	membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09619	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0812	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR016243	C	From MGI
	GO:0016301	kinase activity	MGI:MGI:2664443 PMID:12808090^[8]	IMP: Inferred from Mutant Phenotype		F	From MGI
	GO:0016310	phosphorylation	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	P	From MGI
	GO:0016324	apical plasma membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q05030	C	From MGI
	GO:0016477	cell migration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09619	P	From MGI
	GO:0016740	transferase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0808	F	From MGI
	GO:0016772	transferase activity, transferring phosphorus-containing groups	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F	From MGI
	GO:0018108	peptidyl-tyrosine phosphorylation	MGI:MGI:2680741 PMID:14624252^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0018108	peptidyl-tyrosine phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09619	P	From MGI
	GO:0030325	adrenal gland development	MGI:MGI:3820330 PMID:19056881^[10]	IGI: Inferred from Genetic Interaction	MGI:MGI:97530	P	From MGI
	GO:0030335	positive regulation of cell migration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09619	P	From MGI
	GO:0031226	intrinsic to plasma membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09619	C	From MGI
	GO:0031410	cytoplasmic vesicle	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0968	C	From MGI
	GO:0032516	positive regulation of phosphoprotein phosphatase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09619	P	From MGI
	GO:0032956	regulation of actin cytoskeleton organization	MGI:MGI:4365879 PMID:19742316^[7]	IGI: Inferred from Genetic Interaction	UniProtKB:Q91ZX7	P	From MGI
	GO:0032967	positive regulation of collagen biosynthetic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q05030	P	From MGI
	GO:0035441	cell migration involved in vasculogenesis	MGI:MGI:2680741 PMID:14624252^[9]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0035789	metanephric mesenchymal cell migration	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q05030	P	From MGI
	GO:0035791	platelet-derived growth factor receptor-beta signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09619	P	From MGI
	GO:0035793	positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	MGI:MGI:5284758 PMID:19019919^[11]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0035909	aorta morphogenesis	MGI:MGI:4365879 PMID:19742316^[7]	IGI: Inferred from Genetic Interaction	UniProtKB:Q91ZX7	P	From MGI
	GO:0036120	cellular response to platelet-derived growth factor stimulus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q05030	P	From MGI
	GO:0038084	vascular endothelial growth factor signaling pathway	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR009134	P	From MGI
	GO:0038085	vascular endothelial growth factor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09619	F	From MGI
	GO:0038091	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09619	P	From MGI
	GO:0043406	positive regulation of MAP kinase activity	MGI:MGI:5009390 PMID:17942966^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0043548	phosphatidylinositol 3-kinase binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q05030	F	From MGI
	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09619	P	From MGI
	GO:0045768	positive regulation of anti-apoptosis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q05030	P	From MGI
	GO:0045840	positive regulation of mitosis	MGI:MGI:5009390 PMID:17942966^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0046488	phosphatidylinositol metabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09619	P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:2680741 PMID:14624252^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09619	P	From MGI
	GO:0048008	platelet-derived growth factor receptor signaling pathway	MGI:MGI:3696608 PMID:17143286^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135508	P	From MGI
	GO:0048008	platelet-derived growth factor receptor signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q05030	P	From MGI
	GO:0048008	platelet-derived growth factor receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09619	P	From MGI
	GO:0048010	vascular endothelial growth factor receptor signaling pathway	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR009134	P	From MGI
	GO:0048015	phosphatidylinositol-mediated signaling	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09619	P	From MGI
	GO:0048407	platelet-derived growth factor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09619	F	From MGI
	GO:0048407	platelet-derived growth factor binding	MGI:MGI:4943617 PMID:20299672^[12]	TAS: Traceable Author Statement		F	From MGI
	GO:0048661	positive regulation of smooth muscle cell proliferation	MGI:MGI:1338343 PMID:10375497^[6]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0048661	positive regulation of smooth muscle cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09619	P	From MGI
	GO:0048705	skeletal system morphogenesis	MGI:MGI:3696608 PMID:17143286^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135508	P	From MGI
	GO:0048745	smooth muscle tissue development	MGI:MGI:3696608 PMID:17143286^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2135508	P	From MGI
	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	MGI:MGI:2182234 PMID:11940581^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0050921	positive regulation of chemotaxis	MGI:MGI:5284758 PMID:19019919^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0055003	cardiac myofibril assembly	MGI:MGI:1931346 PMID:11239463^[13]	IGI: Inferred from Genetic Interaction	UniProtKB:P26618	P	From MGI
	GO:0060326	cell chemotaxis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09619	P	From MGI
	GO:0060947	cardiac vascular smooth muscle cell differentiation	MGI:MGI:4943617 PMID:20299672^[12]	TAS: Traceable Author Statement		P	From MGI
	GO:0060981	cell migration involved in coronary angiogenesis	MGI:MGI:2680741 PMID:14624252^[9]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0061298	retina vasculature development in camera-type eye	MGI:MGI:1931346 PMID:11239463^[13]	IGI: Inferred from Genetic Interaction	UniProtKB:P26618	P	From MGI
	GO:0061298	retina vasculature development in camera-type eye	MGI:MGI:2680741 PMID:14624252^[9]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0070374	positive regulation of ERK1 and ERK2 cascade	MGI:MGI:2680741 PMID:14624252^[9]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0070374	positive regulation of ERK1 and ERK2 cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P09619	P	From MGI
	GO:0070374	positive regulation of ERK1 and ERK2 cascade	MGI:MGI:5009390 PMID:17942966^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0071670	smooth muscle cell chemotaxis	MGI:MGI:4365879 PMID:19742316^[7]	IGI: Inferred from Genetic Interaction	UniProtKB:Q91ZX7	P	From MGI
	GO:0072262	metanephric glomerular mesangial cell proliferation involved in metanephros development	MGI:MGI:1289803 PMID:9693135^[14]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0072277	metanephric glomerular capillary formation	MGI:MGI:1931346 PMID:11239463^[13]	IGI: Inferred from Genetic Interaction	UniProtKB:P26618	P	From MGI
	GO:0090280	positive regulation of calcium ion import	MGI:MGI:5284758 PMID:19019919^[11]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:2000379	positive regulation of reactive oxygen species metabolic process	MGI:MGI:5284758 PMID:19019919^[11]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:2000573	positive regulation of DNA biosynthetic process	MGI:MGI:5284758 PMID:19019919^[11]	IMP: Inferred from Mutant Phenotype		P	From MGI
NOT	GO:0030097	hemopoiesis	MGI:MGI:1932685 PMID:11264163^[15]	IMP: Inferred from Mutant Phenotype		P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Schmahl J et al. (2007) PDGF signaling specificity is mediated through multiple immediate early genes. Nat Genet 39: 52-60 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Saito Y et al. (2002) Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor. J Biol Chem 277: 23216-22 PubMed GONUTS page
↑ ^3.0 ^3.1 Takahashi Y et al. (2006) PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling. EMBO J 25: 910-20 PubMed GONUTS page
↑ Riedel H et al. (2000) PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated mitogenesis. Oncogene 19: 39-50 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Wagner B et al. (2007) Mitogenic signaling via platelet-derived growth factor beta in metanephric mesenchymal cells. J Am Soc Nephrol 18: 2903-11 PubMed GONUTS page
↑ ^6.0 ^6.1 Hellström M et al. (1999) Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development 126: 3047-55 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Zhou L et al. (2009) LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation. PLoS One 4: e6922 PubMed GONUTS page
↑ Holgado-Madruga M & Wong AJ (2003) Gab1 is an integrator of cell death versus cell survival signals in oxidative stress. Mol Cell Biol 23: 4471-84 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Tallquist MD et al. (2003) Additive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell development. PLoS Biol 1: E52 PubMed GONUTS page
↑ Schmahl J et al. (2008) The PDGF signaling pathway controls multiple steroid-producing lineages. Genes Dev 22: 3255-67 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Ricono JM et al. (2009) PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by PDGF AA. Am J Physiol Renal Physiol 296: F406-17 PubMed GONUTS page
↑ ^12.0 ^12.1 Olivey HE & Svensson EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ Res 106: 818-32 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Klinghoffer RA et al. (2001) The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions. Mol Cell 7: 343-54 PubMed GONUTS page
↑ Lindahl P et al. (1998) Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli. Development 125: 3313-22 PubMed GONUTS page
↑ Kaminski WE et al. (2001) Basis of hematopoietic defects in platelet-derived growth factor (PDGF)-B and PDGF beta-receptor null mice. Blood 97: 1990-8 PubMed GONUTS page

[PMID:17143286-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Schmahl J et al. (2007) PDGF signaling specificity is mediated through multiple immediate early genes. Nat Genet 39: 52-60 PubMed GONUTS page

[PMID:11940581-1] 2.0 ^2.1 ^2.2 Saito Y et al. (2002) Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor. J Biol Chem 277: 23216-22 PubMed GONUTS page

[PMID:16456542-2] 3.0 ^3.1 Takahashi Y et al. (2006) PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling. EMBO J 25: 910-20 PubMed GONUTS page

[PMID:10644978-3] Riedel H et al. (2000) PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated mitogenesis. Oncogene 19: 39-50 PubMed GONUTS page

[PMID:17942966-4] 5.0 ^5.1 ^5.2 ^5.3 Wagner B et al. (2007) Mitogenic signaling via platelet-derived growth factor beta in metanephric mesenchymal cells. J Am Soc Nephrol 18: 2903-11 PubMed GONUTS page

[PMID:10375497-5] 6.0 ^6.1 Hellström M et al. (1999) Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development 126: 3047-55 PubMed GONUTS page

[PMID:19742316-6] 7.0 ^7.1 ^7.2 ^7.3 Zhou L et al. (2009) LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation. PLoS One 4: e6922 PubMed GONUTS page

[PMID:12808090-7] Holgado-Madruga M & Wong AJ (2003) Gab1 is an integrator of cell death versus cell survival signals in oxidative stress. Mol Cell Biol 23: 4471-84 PubMed GONUTS page

[PMID:14624252-8] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Tallquist MD et al. (2003) Additive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell development. PLoS Biol 1: E52 PubMed GONUTS page

[PMID:19056881-9] Schmahl J et al. (2008) The PDGF signaling pathway controls multiple steroid-producing lineages. Genes Dev 22: 3255-67 PubMed GONUTS page

[PMID:19019919-10] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Ricono JM et al. (2009) PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by PDGF AA. Am J Physiol Renal Physiol 296: F406-17 PubMed GONUTS page

[PMID:20299672-11] 12.0 ^12.1 Olivey HE & Svensson EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ Res 106: 818-32 PubMed GONUTS page

[PMID:11239463-12] 13.0 ^13.1 ^13.2 Klinghoffer RA et al. (2001) The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions. Mol Cell 7: 343-54 PubMed GONUTS page

[PMID:9693135-13] Lindahl P et al. (1998) Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli. Development 125: 3313-22 PubMed GONUTS page

[PMID:11264163-14] Kaminski WE et al. (2001) Basis of hematopoietic defects in platelet-derived growth factor (PDGF)-B and PDGF beta-receptor null mice. Blood 97: 1990-8 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Pdgfrb ( synonyms: CD140b, Pdgfr )
Protein Name(s)	platelet derived growth factor receptor, beta polypeptide,
External Links
MGI	MGI:97531

MGI:Pdgfrb

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