![]()
GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MGI:Pdcd6
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Pdcd6 ( synonyms: alg-2, Alg2, MA-3, PS2 ) | |
| Protein Name(s) | programmed cell death 6, | |
| External Links | ||
| MGI | MGI:109283 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005509 |
calcium ion binding |
MGI:MGI:3763292 |
IMP: Inferred from Mutant Phenotype |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2684521 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3609918 |
IPI: Inferred from Physical Interaction |
UniProtKB:P70389 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:4456958 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005625 |
soluble fraction |
MGI:MGI:2684521 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3763292 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005783 |
endoplasmic reticulum |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005792 |
microsome |
MGI:MGI:2684521 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006886 |
intracellular protein transport |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006915 |
apoptotic process |
MGI:MGI:81240 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
MGI:MGI:2684521 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0031410 |
cytoplasmic vesicle |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0033554 |
cellular response to stress |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:1333264 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0046983 |
protein dimerization activity |
MGI:MGI:1333264 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0046983 |
protein dimerization activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0048306 |
calcium-dependent protein binding |
MGI:MGI:3763292 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0048306 |
calcium-dependent protein binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0051592 |
response to calcium ion |
MGI:MGI:3763292 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060090 |
binding, bridging |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 la Cour JM et al. (2007) ALG-2 oscillates in subcellular localization, unitemporally with calcium oscillations. Biochem Biophys Res Commun 353: 1063-7 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Rao RV et al. (2004) Molecular components of a cell death pathway activated by endoplasmic reticulum stress. J Biol Chem 279: 177-87 PubMed GONUTS page
- ↑ Suzuki H et al. (2001) Protein-protein interaction panel using mouse full-length cDNAs. Genome Res 11: 1758-65 PubMed GONUTS page
- ↑ Jung YS et al. (2001) Apoptosis-linked gene 2 binds to the death domain of Fas and dissociates from Fas during Fas-mediated apoptosis in Jurkat cells. Biochem Biophys Res Commun 288: 420-6 PubMed GONUTS page
- ↑ Vito P et al. (1996) Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3. Science 271: 521-5 PubMed GONUTS page
- ↑ 6.0 6.1 Missotten M et al. (1999) Alix, a novel mouse protein undergoing calcium-dependent interaction with the apoptosis-linked-gene 2 (ALG-2) protein. Cell Death Differ 6: 124-9 PubMed GONUTS page