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MGI:Parp1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Parp1 ( synonyms: Adprp, Adprt1, PARP, parp-1, sPARP-1 ) | |
| Protein Name(s) | poly (ADP-ribose) polymerase family, member 1, | |
| External Links | ||
| MGI | MGI:1340806 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000723 |
telomere maintenance |
MGI:MGI:2656673 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857862 |
P |
From MGI |
||
| GO:0003950 |
NAD+ ADP-ribosyltransferase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003950 |
NAD+ ADP-ribosyltransferase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2386520 |
TAS: Traceable Author Statement |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005635 |
nuclear envelope |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005654 |
nucleoplasm |
MGI:MGI:3522381 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005667 |
transcription factor complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005730 |
nucleolus |
MGI:MGI:3522381 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005730 |
nucleolus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006259 |
DNA metabolic process |
MGI:MGI:2157189 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006259 |
DNA metabolic process |
MGI:MGI:2656673 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857862 |
P |
From MGI |
||
| GO:0006281 |
DNA repair |
MGI:MGI:2386520 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0006284 |
base-excision repair |
MGI:MGI:2181257 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006471 |
protein ADP-ribosylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006471 |
protein ADP-ribosylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008134 |
transcription factor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0016540 |
protein autoprocessing |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032869 |
cellular response to insulin stimulus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0040009 |
regulation of growth rate |
MGI:MGI:2656673 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857862 |
P |
From MGI |
||
| GO:0042769 |
DNA damage response, detection of DNA damage |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043234 |
protein complex |
MGI:MGI:4367296 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0047485 |
protein N-terminus binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0051287 |
NAD binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0070212 |
protein poly-ADP-ribosylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Lebel M et al. (2003) Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice. Am J Pathol 162: 1559-69 PubMed GONUTS page
- ↑ 2.0 2.1 Benchoua A et al. (2002) Active caspase-8 translocates into the nucleus of apoptotic cells to inactivate poly(ADP-ribose) polymerase-2. J Biol Chem 277: 34217-22 PubMed GONUTS page
- ↑ 3.0 3.1 Meder VS et al. (2005) PARP-1 and PARP-2 interact with nucleophosmin/B23 and accumulate in transcriptionally active nucleoli. J Cell Sci 118: 211-22 PubMed GONUTS page
- ↑ Lebel M (2002) Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologue. Carcinogenesis 23: 213-6 PubMed GONUTS page
- ↑ Schreiber V et al. (2002) Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1. J Biol Chem 277: 23028-36 PubMed GONUTS page
- ↑ Nishiyama A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5: 420-33 PubMed GONUTS page
