MGI:Park7

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0001963	synaptic transmission, dopaminergic	MGI:MGI:3584207 PMID:15799973^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3586448	P	From MGI
	GO:0003723	RNA binding	MGI:MGI:1934163 PMID:11223268^[2]	TAS: Traceable Author Statement		F	From MGI
	GO:0003729	mRNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99497	F	From MGI
	GO:0004601	peroxidase activity	MGI:MGI:3723371 PMID:17766438^[3]	IMP: Inferred from Mutant Phenotype		F	From MGI
	GO:0005634	nucleus	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:Q99497	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:Q99497	C	From MGI
	GO:0005739	mitochondrion	MGI:MGI:3723371 PMID:17766438^[3]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005739	mitochondrion	MGI:MGI:3852644 PMID:18614015^[4]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005739	mitochondrion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99497	C	From MGI
	GO:0005829	cytosol	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O88767	C	From MGI
	GO:0006508	proteolysis	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0645	P	From MGI
	GO:0006914	autophagy	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0072	P	From MGI
	GO:0006950	response to stress	MGI:MGI:3653054 PMID:16624565^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3579140	P	From MGI
	GO:0006954	inflammatory response	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0395	P	From MGI
	GO:0006979	response to oxidative stress	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O88767	P	From MGI
	GO:0007005	mitochondrion organization	MGI:MGI:4437348 PMID:20186336^[6]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0007338	single fertilization	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0278	P	From MGI
	GO:0008233	peptidase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99497	F	From MGI
	GO:0008283	cell proliferation	MGI:MGI:1934163 PMID:11223268^[2]	TAS: Traceable Author Statement		P	From MGI
	GO:0008344	adult locomotory behavior	MGI:MGI:3578474 PMID:15721235^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3579140	P	From MGI
	GO:0008344	adult locomotory behavior	MGI:MGI:3584207 PMID:15799973^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3586448	P	From MGI
	GO:0016787	hydrolase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0378	F	From MGI
	GO:0030424	axon	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O88767	C	From MGI
	GO:0032091	negative regulation of protein binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99497	P	From MGI
	GO:0034599	cellular response to oxidative stress	MGI:MGI:4889134 PMID:21068725^[8]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0042542	response to hydrogen peroxide	MGI:MGI:3575338 PMID:15784737^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0042542	response to hydrogen peroxide	MGI:MGI:3575338 PMID:15784737^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3576227	P	From MGI
	GO:0042743	hydrogen peroxide metabolic process	MGI:MGI:3723371 PMID:17766438^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3514165	P	From MGI
	GO:0042803	protein homodimerization activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99497	F	From MGI
	GO:0043526	neuroprotection	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99497	P	From MGI
	GO:0050727	regulation of inflammatory response	MGI:MGI:4943657 PMID:19276172^[10]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0050821	protein stabilization	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99497	P	From MGI
	GO:0050821	protein stabilization	MGI:MGI:4943400 PMID:17015834^[11]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0051583	dopamine uptake	MGI:MGI:3578474 PMID:15721235^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3579140	P	From MGI
	GO:0051899	membrane depolarization	MGI:MGI:3653054 PMID:16624565^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3579140	P	From MGI
	GO:0051920	peroxiredoxin activity	MGI:MGI:3723371 PMID:17766438^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3514165	F	From MGI
	GO:0060081	membrane hyperpolarization	MGI:MGI:3653054 PMID:16624565^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3579140	P	From MGI
	GO:0060548	negative regulation of cell death	MGI:MGI:3575338 PMID:15784737^[9]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0060548	negative regulation of cell death	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99497	P	From MGI
	GO:0060765	regulation of androgen receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99497	P	From MGI
	GO:0070301	cellular response to hydrogen peroxide	MGI:MGI:3575338 PMID:15784737^[9]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0070301	cellular response to hydrogen peroxide	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99497	P	From MGI
	GO:2000277	positive regulation of oxidative phosphorylation uncoupler activity	MGI:MGI:4889134 PMID:21068725^[8]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99497	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Chen L et al. (2005) Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice. J Biol Chem 280: 21418-26 PubMed GONUTS page
↑ ^2.0 ^2.1 Taira T et al. (2001) Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter. Gene 263: 285-92 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Andres-Mateos E et al. (2007) DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. Proc Natl Acad Sci U S A 104: 14807-12 PubMed GONUTS page
↑ Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-23 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Pisani A et al. (2006) Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to energy metabolism impairment: role of Na+/K+ ATPase. Neurobiol Dis 23: 54-60 PubMed GONUTS page
↑ Krebiehl G et al. (2010) Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1. PLoS One 5: e9367 PubMed GONUTS page
↑ ^7.0 ^7.1 Goldberg MS et al. (2005) Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron 45: 489-96 PubMed GONUTS page
↑ ^8.0 ^8.1 Guzman JN et al. (2010) Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1. Nature 468: 696-700 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Kim RH et al. (2005) Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc Natl Acad Sci U S A 102: 5215-20 PubMed GONUTS page
↑ Waak J et al. (2009) Regulation of astrocyte inflammatory responses by the Parkinson's disease-associated gene DJ-1. FASEB J 23: 2478-89 PubMed GONUTS page
↑ Clements CM et al. (2006) DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proc Natl Acad Sci U S A 103: 15091-6 PubMed GONUTS page

[PMID:15799973-0] 1.0 ^1.1 Chen L et al. (2005) Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice. J Biol Chem 280: 21418-26 PubMed GONUTS page

[PMID:11223268-1] 2.0 ^2.1 Taira T et al. (2001) Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter. Gene 263: 285-92 PubMed GONUTS page

[PMID:17766438-2] 3.0 ^3.1 ^3.2 ^3.3 Andres-Mateos E et al. (2007) DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. Proc Natl Acad Sci U S A 104: 14807-12 PubMed GONUTS page

[PMID:18614015-3] Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-23 PubMed GONUTS page

[PMID:16624565-4] 5.0 ^5.1 ^5.2 Pisani A et al. (2006) Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to energy metabolism impairment: role of Na+/K+ ATPase. Neurobiol Dis 23: 54-60 PubMed GONUTS page

[PMID:20186336-5] Krebiehl G et al. (2010) Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1. PLoS One 5: e9367 PubMed GONUTS page

[PMID:15721235-6] 7.0 ^7.1 Goldberg MS et al. (2005) Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron 45: 489-96 PubMed GONUTS page

[PMID:21068725-7] 8.0 ^8.1 Guzman JN et al. (2010) Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1. Nature 468: 696-700 PubMed GONUTS page

[PMID:15784737-8] 9.0 ^9.1 ^9.2 ^9.3 Kim RH et al. (2005) Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc Natl Acad Sci U S A 102: 5215-20 PubMed GONUTS page

[PMID:19276172-9] Waak J et al. (2009) Regulation of astrocyte inflammatory responses by the Parkinson's disease-associated gene DJ-1. FASEB J 23: 2478-89 PubMed GONUTS page

[PMID:17015834-10] Clements CM et al. (2006) DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proc Natl Acad Sci U S A 103: 15091-6 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Park7 ( synonyms: DJ-1 )
Protein Name(s)	Parkinson disease (autosomal recessive, early onset) 7,
External Links
MGI	MGI:2135637

MGI:Park7

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