GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MGI:Pard3
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Pard3 ( synonyms: ASIP, D8Ertd580e, PAR-3, Par3, Pard3a ) | |
| Protein Name(s) | par-3 (partitioning defective 3) homolog (C. elegans), | |
| External Links | ||
| MGI | MGI:2135608 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000226 |
microtubule cytoskeleton organization |
MGI:MGI:4359132 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0003383 |
apical constriction |
MGI:MGI:5086051 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:2442579 |
P |
From MGI |
||
| GO:0005080 |
protein kinase C binding |
MGI:MGI:3616720 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3687818 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3768317 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4359132 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4420836 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005546 |
phosphatidylinositol-4,5-bisphosphate binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_112514 |
F |
From MGI |
||
| GO:0005547 |
phosphatidylinositol-3,4,5-trisphosphate binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_112514 |
F |
From MGI |
||
| GO:0005622 |
intracellular |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_112514 |
C |
From MGI |
||
| GO:0005737 |
cytoplasm |
MGI:MGI:3577813 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005819 |
spindle |
MGI:MGI:3577813 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005856 |
cytoskeleton |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0206 |
C |
From MGI |
||
| GO:0005911 |
cell-cell junction |
MGI:MGI:3574751 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005911 |
cell-cell junction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_112514 |
C |
From MGI |
||
| GO:0005911 |
cell-cell junction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005912 |
adherens junction |
MGI:MGI:2386382 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005912 |
adherens junction |
MGI:MGI:4420836 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005913 |
cell-cell adherens junction |
MGI:MGI:2450499 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005923 |
tight junction |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005923 |
tight junction |
MGI:MGI:3687818 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005938 |
cell cortex |
MGI:MGI:3577813 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006612 |
protein targeting to membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_112514 |
P |
From MGI |
||
| GO:0007049 |
cell cycle |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0131 |
P |
From MGI |
||
| GO:0007163 |
establishment or maintenance of cell polarity |
MGI:MGI:3687818 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0008289 |
lipid binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0446 |
F |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016337 |
cell-cell adhesion |
MGI:MGI:2450499 |
IC: Inferred by Curator |
GO:0005913 |
P |
From MGI |
||
| GO:0019903 |
protein phosphatase binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_112514 |
F |
From MGI |
||
| GO:0030054 |
cell junction |
MGI:MGI:4359132 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0032266 |
phosphatidylinositol-3-phosphate binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_112514 |
F |
From MGI |
||
| GO:0032970 |
regulation of actin filament-based process |
MGI:MGI:5086051 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:2442579 |
P |
From MGI |
||
| GO:0043025 |
neuronal cell body |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_112514 |
C |
From MGI |
||
| GO:0043219 |
lateral loop |
MGI:MGI:4441217 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0043220 |
Schmidt-Lanterman incisure |
MGI:MGI:4441217 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0043234 |
protein complex |
MGI:MGI:3616720 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0043234 |
protein complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_112514 |
C |
From MGI |
||
| GO:0044295 |
axonal growth cone |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_112514 |
C |
From MGI |
||
| GO:0044319 |
wound healing, spreading of cells |
MGI:MGI:4359132 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045177 |
apical part of cell |
MGI:MGI:4950299 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0051301 |
cell division |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0132 |
P |
From MGI |
||
| GO:0051642 |
centrosome localization |
MGI:MGI:4359132 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060341 |
regulation of cellular localization |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_112514 |
P |
From MGI |
||
| GO:0070830 |
tight junction assembly |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_112514 |
P |
From MGI |
||
| GO:0090162 |
establishment of epithelial cell polarity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_112514 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Schmoranzer J et al. (2009) Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migration. Curr Biol 19: 1065-74 PubMed GONUTS page
- ↑ 2.0 2.1 Ishiuchi T & Takeichi M (2011) Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation. Nat Cell Biol 13: 860-6 PubMed GONUTS page
- ↑ 3.0 3.1 Wu X et al. (2006) Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev 20: 571-85 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Johansson A et al. (2000) The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1. J Cell Sci 113 ( Pt 18): 3267-75 PubMed GONUTS page
- ↑ Fujita E et al. (2007) Loss of partitioning-defective-3/isotype-specific interacting protein (par-3/ASIP) in the elongating spermatid of RA175 (IGSF4A/SynCAM)-deficient mice. Am J Pathol 171: 1800-10 PubMed GONUTS page
- ↑ 6.0 6.1 Ikenouchi J & Umeda M (2010) FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex. Proc Natl Acad Sci U S A 107: 748-53 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Duncan FE et al. (2005) PAR-3 defines a central subdomain of the cortical actin cap in mouse eggs. Dev Biol 280: 38-47 PubMed GONUTS page
- ↑ Tunggal JA et al. (2005) E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J 24: 1146-56 PubMed GONUTS page
- ↑ Manabe N et al. (2002) Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells. Dev Dyn 225: 61-9 PubMed GONUTS page
- ↑ 10.0 10.1 Takekuni K et al. (2003) Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse. J Biol Chem 278: 5497-500 PubMed GONUTS page
- ↑ 11.0 11.1 Ozçelik M et al. (2010) Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves. J Neurosci 30: 4120-31 PubMed GONUTS page
- ↑ El-Hashash AH et al. (2011) Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium. Development 138: 1395-407 PubMed GONUTS page
