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MGI:Opa1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Opa1 ( synonyms: lilr3 ) | |
| Protein Name(s) | optic atrophy 1 homolog (human), | |
| External Links | ||
| MGI | MGI:1921393 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0001843 |
neural tube closure |
MGI:MGI:3577662 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3578528 |
P |
From MGI |
||
| GO:0003924 |
GTPase activity |
MGI:MGI:2179175 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:5009773 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005525 |
GTP binding |
MGI:MGI:2179175 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:2179175 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:2682130 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:3665364 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:3852644 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005741 |
mitochondrial outer membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005743 |
mitochondrial inner membrane |
MGI:MGI:3590069 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005743 |
mitochondrial inner membrane |
MGI:MGI:3692706 |
IMP: Inferred from Mutant Phenotype |
C |
From MGI |
|||
| GO:0005758 |
mitochondrial intermembrane space |
MGI:MGI:2179175 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006184 |
GTP catabolic process |
MGI:MGI:2179175 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0006915 |
apoptotic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0053 |
P |
From MGI |
||
| GO:0007005 |
mitochondrion organization |
MGI:MGI:2179175 |
NAS: Non-traceable Author Statement |
P |
From MGI |
|||
| GO:0007005 |
mitochondrion organization |
MGI:MGI:4421613 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007007 |
inner mitochondrial membrane organization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007601 |
visual perception |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008053 |
mitochondrial fusion |
MGI:MGI:4421613 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0008053 |
mitochondrial fusion |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0030061 |
mitochondrial crista |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030425 |
dendrite |
MGI:MGI:2179175 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0045768 |
positive regulation of anti-apoptosis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050896 |
response to stimulus |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0716 |
P |
From MGI |
||
| GO:0090201 |
negative regulation of release of cytochrome c from mitochondria |
MGI:MGI:3692706 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:2001243 |
negative regulation of intrinsic apoptotic signaling pathway |
MGI:MGI:3692706 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ García-García MJ et al. (2005) Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc Natl Acad Sci U S A 102: 5913-9 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Misaka T et al. (2002) Primary structure of a dynamin-related mouse mitochondrial GTPase and its distribution in brain, subcellular localization, and effect on mitochondrial morphology. J Biol Chem 277: 15834-42 PubMed GONUTS page
- ↑ Darshi M et al. (2011) ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function. J Biol Chem 286: 2918-32 PubMed GONUTS page
- ↑ Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115: 629-40 PubMed GONUTS page
- ↑ Karbowski M et al. (2006) Role of Bax and Bak in mitochondrial morphogenesis. Nature 443: 658-62 PubMed GONUTS page
- ↑ Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-23 PubMed GONUTS page
- ↑ Da Cruz S et al. (2003) Proteomic analysis of the mouse liver mitochondrial inner membrane. J Biol Chem 278: 41566-71 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Cipolat S et al. (2006) Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cell 126: 163-75 PubMed GONUTS page
- ↑ 9.0 9.1 Ehses S et al. (2009) Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1. J Cell Biol 187: 1023-36 PubMed GONUTS page
