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MGI:Olig2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Olig2 ( synonyms: Bhlhb1, bHLHe19, Olg-2, RK17 ) | |
| Protein Name(s) | oligodendrocyte transcription factor 2, | |
| External Links | ||
| MGI | MGI:1355331 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3526794 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0238 |
F |
From MGI |
||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:1353798 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:2679388 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003705 |
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity |
MGI:MGI:3526794 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3706482 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2679388 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005667 |
transcription factor complex |
MGI:MGI:1353798 |
ISS: Inferred from Sequence or Structural Similarity |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:2679388 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:1353798 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From MGI |
|||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:2679388 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0217 |
P |
From MGI |
||
| GO:0007399 |
nervous system development |
MGI:MGI:2679388 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0021522 |
spinal cord motor neuron differentiation |
MGI:MGI:5140688 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3774124 |
P |
From MGI |
||
| GO:0021529 |
spinal cord oligodendrocyte cell differentiation |
MGI:MGI:3794240 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96919 |
P |
From MGI |
||
| GO:0021530 |
spinal cord oligodendrocyte cell fate specification |
MGI:MGI:3794240 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042552 |
myelination |
MGI:MGI:3613362 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3614399 |
P |
From MGI |
||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:3526794 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0045665 |
negative regulation of neuron differentiation |
MGI:MGI:2150513 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048663 |
neuron fate commitment |
MGI:MGI:2177979 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179312 |
P |
From MGI |
||
| GO:0048709 |
oligodendrocyte differentiation |
MGI:MGI:3613362 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3614399 |
P |
From MGI |
||
| GO:0048714 |
positive regulation of oligodendrocyte differentiation |
MGI:MGI:2150513 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97347 |
P |
From MGI |
||
| GO:0071837 |
HMG box domain binding |
MGI:MGI:5284787 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Lee SK et al. (2005) Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells. Genes Dev 19: 282-94 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Zhou Q et al. (2000) Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. Neuron 25: 331-43 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Sun T et al. (2003) Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex. J Neurosci 23: 9547-56 PubMed GONUTS page
- ↑ Samanta J & Kessler JA (2004) Interactions between ID and OLIG proteins mediate the inhibitory effects of BMP4 on oligodendroglial differentiation. Development 131: 4131-42 PubMed GONUTS page
- ↑ Chen JA et al. (2011) Mir-17-3p controls spinal neural progenitor patterning by regulating Olig2/Irx3 cross-repressive loop. Neuron 69: 721-35 PubMed GONUTS page
- ↑ 6.0 6.1 Sugimori M et al. (2008) Ascl1 is required for oligodendrocyte development in the spinal cord. Development 135: 1271-81 PubMed GONUTS page
- ↑ 7.0 7.1 Yue T et al. (2006) A critical role for dorsal progenitors in cortical myelination. J Neurosci 26: 1275-80 PubMed GONUTS page
- ↑ 8.0 8.1 Sun T et al. (2001) Olig bHLH proteins interact with homeodomain proteins to regulate cell fate acquisition in progenitors of the ventral neural tube. Curr Biol 11: 1413-20 PubMed GONUTS page
- ↑ Lu QR et al. (2002) Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Cell 109: 75-86 PubMed GONUTS page
- ↑ Wissmüller S et al. (2006) The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. Nucleic Acids Res 34: 1735-44 PubMed GONUTS page
