GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MGI:Ogg1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Ogg1 ( synonyms: Mmh ) | |
| Protein Name(s) | 8-oxoguanine DNA-glycosylase 1, | |
| External Links | ||
| MGI | MGI:1097693 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000702 |
oxidized base lesion DNA N-glycosylase activity |
MGI:MGI:2389521 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0003684 |
damaged DNA binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003824 |
catalytic activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0511 |
F |
From MGI |
||
| GO:0003824 |
catalytic activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0003906 |
DNA-(apurinic or apyrimidinic site) lyase activity |
MGI:MGI:2152096 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1347747 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386943 |
C |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005654 |
nucleoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:2137151 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386943 |
C |
From MGI |
||
| GO:0005739 |
mitochondrion |
MGI:MGI:2682130 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:3852644 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006281 |
DNA repair |
MGI:MGI:2150199 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386943 |
P |
From MGI |
||
| GO:0006281 |
DNA repair |
MGI:MGI:2668786 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386212 |
P |
From MGI |
||
| GO:0006281 |
DNA repair |
MGI:MGI:3715683 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1100494 |
P |
From MGI |
||
| GO:0006281 |
DNA repair |
MGI:MGI:3715683 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386943 |
P |
From MGI |
||
| GO:0006281 |
DNA repair |
MGI:MGI:3759387 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1100494 |
P |
From MGI |
||
| GO:0006281 |
DNA repair |
MGI:MGI:3759387 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386943 |
P |
From MGI |
||
| GO:0006284 |
base-excision repair |
MGI:MGI:1349233 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386943 |
P |
From MGI |
||
| GO:0006284 |
base-excision repair |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006284 |
base-excision repair |
MGI:MGI:894433 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006289 |
nucleotide-excision repair |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006974 |
response to DNA damage stimulus |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0227 |
P |
From MGI |
||
| GO:0006979 |
response to oxidative stress |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008017 |
microtubule binding |
MGI:MGI:3573988 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0008534 |
oxidized purine base lesion DNA N-glycosylase activity |
MGI:MGI:1347747 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386943 |
F |
From MGI |
||
| GO:0008534 |
oxidized purine base lesion DNA N-glycosylase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008534 |
oxidized purine base lesion DNA N-glycosylase activity |
MGI:MGI:894433 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0009314 |
response to radiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016363 |
nuclear matrix |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016607 |
nuclear speck |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016787 |
hydrolase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0378 |
F |
From MGI |
||
| GO:0016798 |
hydrolase activity, acting on glycosyl bonds |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0326 |
F |
From MGI |
||
| GO:0016829 |
lyase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0456 |
F |
From MGI |
||
| GO:0019104 |
DNA N-glycosylase activity |
MGI:MGI:2389521 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0019104 |
DNA N-glycosylase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0032355 |
response to estradiol stimulus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0033158 |
regulation of protein import into nucleus, translocation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0034039 |
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity |
MGI:MGI:3759387 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386943 |
F |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Takao M et al. (2002) A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue. J Biol Chem 277: 42205-13 PubMed GONUTS page
- ↑ 2.0 2.1 Klungland A et al. (1999) Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage. Proc Natl Acad Sci U S A 96: 13300-5 PubMed GONUTS page
- ↑ de Souza-Pinto NC et al. (2001) Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice. Cancer Res 61: 5378-81 PubMed GONUTS page
- ↑ Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115: 629-40 PubMed GONUTS page
- ↑ Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-23 PubMed GONUTS page
- ↑ Osterod M et al. (2001) Age-related and tissue-specific accumulation of oxidative DNA base damage in 7,8-dihydro-8-oxoguanine-DNA glycosylase (Ogg1) deficient mice. Carcinogenesis 22: 1459-63 PubMed GONUTS page
- ↑ Arai T et al. (2003) Cell proliferation in liver of Mmh/Ogg1-deficient mice enhances mutation frequency because of the presence of 8-hydroxyguanine in DNA. Cancer Res 63: 4287-92 PubMed GONUTS page
- ↑ 8.0 8.1 Trapp C et al. (2007) Deficiency of the Cockayne syndrome B (CSB) gene aggravates the genomic instability caused by endogenous oxidative DNA base damage in mice. Oncogene 26: 4044-8 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Osterod M et al. (2002) A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA base damage. Oncogene 21: 8232-9 PubMed GONUTS page
- ↑ Freedman SD et al. (1999) A membrane lipid imbalance plays a role in the phenotypic expression of cystic fibrosis in cftr(-/-) mice. Proc Natl Acad Sci U S A 96: 13995-4000 PubMed GONUTS page
- ↑ 11.0 11.1 Rosenquist TA et al. (1997) Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase. Proc Natl Acad Sci U S A 94: 7429-34 PubMed GONUTS page
- ↑ Conlon KA et al. (2005) The murine DNA glycosylase NEIL2 (mNEIL2) and human DNA polymerase beta bind microtubules in situ and in vitro. DNA Repair (Amst) 4: 419-31 PubMed GONUTS page
