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MGI:Numb
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Numb ( synonyms: m-numb ) | |
| Protein Name(s) | numb gene homolog (Drosophila), | |
| External Links | ||
| MGI | MGI:107423 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005515 |
protein binding |
MGI:MGI:2154821 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3763347 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:5285151 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1347371 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:1347371 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005769 |
early endosome |
MGI:MGI:2157170 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0217 |
P |
From MGI |
||
| GO:0007399 |
nervous system development |
MGI:MGI:1859482 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1932086 |
P |
From MGI |
||
| GO:0007399 |
nervous system development |
MGI:MGI:2683798 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1932085 |
P |
From MGI |
||
| GO:0007405 |
neuroblast proliferation |
MGI:MGI:2389562 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:894702 |
P |
From MGI |
||
| GO:0007409 |
axonogenesis |
MGI:MGI:3526784 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007409 |
axonogenesis |
MGI:MGI:3526784 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1932085 |
P |
From MGI |
||
| GO:0008013 |
beta-catenin binding |
MGI:MGI:3721043 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016323 |
basolateral plasma membrane |
MGI:MGI:3721043 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0019897 |
extrinsic to plasma membrane |
MGI:MGI:1347371 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0021670 |
lateral ventricle development |
MGI:MGI:3763347 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0021849 |
neuroblast division in subventricular zone |
MGI:MGI:3763347 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030862 |
positive regulation of polarized epithelial cell differentiation |
MGI:MGI:4950299 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030900 |
forebrain development |
MGI:MGI:2683798 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1932085 |
P |
From MGI |
||
| GO:0034332 |
adherens junction organization |
MGI:MGI:3721043 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:894702 |
P |
From MGI |
||
| GO:0045177 |
apical part of cell |
MGI:MGI:2387984 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0045177 |
apical part of cell |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_579821 |
C |
From MGI |
||
| GO:0045177 |
apical part of cell |
MGI:MGI:4950299 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0045294 |
alpha-catenin binding |
MGI:MGI:3721043 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0045296 |
cadherin binding |
MGI:MGI:3721043 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0045664 |
regulation of neuron differentiation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_579821 |
P |
From MGI |
||
| GO:0045746 |
negative regulation of Notch signaling pathway |
MGI:MGI:4950299 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0050769 |
positive regulation of neurogenesis |
MGI:MGI:2389562 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0050775 |
positive regulation of dendrite morphogenesis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_579821 |
P |
From MGI |
||
| GO:0060487 |
lung epithelial cell differentiation |
MGI:MGI:4950299 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
|
NOT |
GO:0016324 |
apical plasma membrane |
MGI:MGI:3721043 |
IDA: Inferred from Direct Assay |
C |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Rice DS et al. (2001) The Lnx family proteins function as molecular scaffolds for Numb family proteins. Mol Cell Neurosci 18: 525-40 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Kuo CT et al. (2006) Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. Cell 127: 1253-64 PubMed GONUTS page
- ↑ Di Marcotullio L et al. (2011) Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal. Oncogene 30: 65-76 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Fernández-Chacón R et al. (1999) Analysis of SCAMP1 function in secretory vesicle exocytosis by means of gene targeting in mice. J Biol Chem 274: 32551-4 PubMed GONUTS page
- ↑ Nie J et al. (2002) LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation. EMBO J 21: 93-102 PubMed GONUTS page
- ↑ Zhong W et al. (2000) Mouse numb is an essential gene involved in cortical neurogenesis. Proc Natl Acad Sci U S A 97: 6844-9 PubMed GONUTS page
- ↑ 7.0 7.1 Li HS et al. (2003) Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis. Neuron 40: 1105-18 PubMed GONUTS page
- ↑ 8.0 8.1 Petersen PH et al. (2002) Progenitor cell maintenance requires numb and numblike during mouse neurogenesis. Nature 419: 929-34 PubMed GONUTS page
- ↑ 9.0 9.1 Huang EJ et al. (2005) Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization. Genes Dev 19: 138-51 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 10.4 10.5 Rasin MR et al. (2007) Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors. Nat Neurosci 10: 819-27 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 El-Hashash AH et al. (2011) Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium. Development 138: 1395-407 PubMed GONUTS page
- ↑ Shen Q et al. (2002) Asymmetric Numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts. Development 129: 4843-53 PubMed GONUTS page
