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MGI:Ntrk3

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Ntrk3 ( synonyms: TrkC )
Protein Name(s) neurotrophic tyrosine kinase, receptor, type 3,
External Links
MGI MGI:97385

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

From MGI

GO:0001764

neuron migration

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q03351

P

From MGI

GO:0004672

protein kinase activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR001245

F

From MGI

GO:0004713

protein tyrosine kinase activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0829

F

From MGI

GO:0004713

protein tyrosine kinase activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR008266
InterPro:IPR020635

F

From MGI

GO:0004714

transmembrane receptor protein tyrosine kinase activity

MGI:MGI:2152096

IEA: Inferred from Electronic Annotation

EC:2.7.10.1

F

From MGI

GO:0004714

transmembrane receptor protein tyrosine kinase activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR020446
InterPro:IPR020777
InterPro:IPR002011

F

From MGI

GO:0004872

receptor activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0675

F

From MGI

GO:0005030

neurotrophin receptor activity

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q03351

F

From MGI

GO:0005515

protein binding

MGI:MGI:2152295
PMID:11684666[1]

IPI: Inferred from Physical Interaction

UniProtKB:P20181

F

From MGI

GO:0005524

ATP binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

From MGI

GO:0005524

ATP binding

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR017441
InterPro:IPR020777
InterPro:IPR002011

F

From MGI

GO:0005624

membrane fraction

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q03351

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:1334487
PMID:10207144[2]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q03351

C

From MGI

GO:0005887

integral to plasma membrane

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR020446
InterPro:IPR020777

C

From MGI

GO:0006468

protein phosphorylation

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR020446
InterPro:IPR008266
InterPro:IPR020635
InterPro:IPR020777
InterPro:IPR002011

P

From MGI

GO:0007165

signal transduction

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q03351

P

From MGI

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR020446
InterPro:IPR020777
InterPro:IPR002011

P

From MGI

GO:0007275

multicellular organismal development

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

From MGI

GO:0007399

nervous system development

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0524

P

From MGI

GO:0016020

membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

From MGI

GO:0016020

membrane

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR002011

C

From MGI

GO:0016021

integral to membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

From MGI

GO:0016301

kinase activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

F

From MGI

GO:0016310

phosphorylation

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

P

From MGI

GO:0016740

transferase activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

From MGI

GO:0016772

transferase activity, transferring phosphorus-containing groups

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR011009

F

From MGI

GO:0030154

cell differentiation

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0221

P

From MGI

GO:0042490

mechanoreceptor differentiation

MGI:MGI:3505841
PMID:15376326[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1888375

P

From MGI

GO:0046777

protein autophosphorylation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q03351

P

From MGI

GO:0048665

neuron fate specification

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q03351

P

From MGI

GO:0048691

positive regulation of axon extension involved in regeneration

MGI:MGI:3604840
PMID:16142215[4]

IGI: Inferred from Genetic Interaction

MGI:MGI:97380

P

From MGI

GO:0048712

negative regulation of astrocyte differentiation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q03351

P

From MGI

GO:0060548

negative regulation of cell death

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q03351

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Coppola V et al. (2001) Dissection of NT3 functions in vivo by gene replacement strategy. Development 128: 4315-27 PubMed GONUTS page
  2. Huang EJ et al. (1999) Expression of Trk receptors in the developing mouse trigeminal ganglion: in vivo evidence for NT-3 activation of TrkA and TrkB in addition to TrkC. Development 126: 2191-203 PubMed GONUTS page
  3. Sedý J et al. (2004) Pacinian corpuscle development involves multiple Trk signaling pathways. Dev Dyn 231: 551-63 PubMed GONUTS page
  4. Stenqvist A et al. (2005) Genetic evidence for selective neurotrophin 3 signalling through TrkC but not TrkB in vivo. EMBO Rep 6: 973-8 PubMed GONUTS page
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