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MGI:Npc2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Npc2 ( synonyms: HE1 ) | |
| Protein Name(s) | Niemann Pick type C2, | |
| External Links | ||
| MGI | MGI:1915213 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005622 |
intracellular |
MGI:MGI:3763329 |
IMP: Inferred from Mutant Phenotype |
C |
From MGI |
|||
| GO:0005764 |
lysosome |
MGI:MGI:3763310 |
ISS: Inferred from Sequence or Structural Similarity |
C |
From MGI |
|||
| GO:0005764 |
lysosome |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0015485 |
cholesterol binding |
MGI:MGI:3763329 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From MGI |
|||
| GO:0015485 |
cholesterol binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019899 |
enzyme binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030301 |
cholesterol transport |
MGI:MGI:3763329 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From MGI |
|||
| GO:0030301 |
cholesterol transport |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032366 |
intracellular sterol transport |
MGI:MGI:3763329 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From MGI |
|||
| GO:0032366 |
intracellular sterol transport |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032367 |
intracellular cholesterol transport |
MGI:MGI:3763329 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0032367 |
intracellular cholesterol transport |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0033344 |
cholesterol efflux |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042632 |
cholesterol homeostasis |
MGI:MGI:3763308 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From MGI |
|||
| GO:0042632 |
cholesterol homeostasis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Liou HL et al. (2006) NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols. J Biol Chem 281: 36710-23 PubMed GONUTS page
- ↑ Naureckiene S et al. (2000) Identification of HE1 as the second gene of Niemann-Pick C disease. Science 290: 2298-301 PubMed GONUTS page
- ↑ Frolov A et al. (2003) NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols. J Biol Chem 278: 25517-25 PubMed GONUTS page
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