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MGI:Nox4

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Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Nox4
Protein Name(s) NADPH oxidase 4,
External Links
MGI MGI:1354184

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000902

cell morphogenesis

MGI:MGI:3694159
PMID:10869423[1]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0005739

mitochondrion

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_445976

C

From MGI

GO:0005783

endoplasmic reticulum

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0256

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-1003

C

From MGI

GO:0005925

focal adhesion

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_445976

C

From MGI

GO:0006801

superoxide metabolic process

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_445976

P

From MGI

GO:0007569

cell aging

MGI:MGI:3694159
PMID:10869423[1]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3694159
PMID:10869423[1]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0014911

positive regulation of smooth muscle cell migration

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_445976

P

From MGI

GO:0016020

membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

From MGI

GO:0016020

membrane

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR000778

C

From MGI

GO:0016021

integral to membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

From MGI

GO:0016174

NAD(P)H oxidase activity

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_445976

F

From MGI

GO:0016175

superoxide-generating NADPH oxidase activity

MGI:MGI:1930898
PMID:11098048[2]

IMP: Inferred from Mutant Phenotype

F

From MGI

GO:0016175

superoxide-generating NADPH oxidase activity

MGI:MGI:5009390
PMID:17942966[3]

IMP: Inferred from Mutant Phenotype

F

From MGI

GO:0016324

apical plasma membrane

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_445976

C

From MGI

GO:0016491

oxidoreductase activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0560

F

From MGI

GO:0016491

oxidoreductase activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR000778
InterPro:IPR013112
InterPro:IPR017927
InterPro:IPR013121
InterPro:IPR017938

F

From MGI

GO:0030054

cell junction

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0965

C

From MGI

GO:0035051

cardiac cell differentiation

MGI:MGI:3689176
PMID:16775014[4]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0042554

superoxide anion generation

MGI:MGI:3694159
PMID:10869423[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0043020

NADPH oxidase complex

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_445976

C

From MGI

GO:0043065

positive regulation of apoptotic process

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_445976

P

From MGI

GO:0043406

positive regulation of MAP kinase activity

MGI:MGI:5009390
PMID:17942966[3]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0045453

bone resorption

MGI:MGI:1930898
PMID:11098048[2]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0048471

perinuclear region of cytoplasm

MGI:MGI:3795840
PMID:18431508[5]

IDA: Inferred from Direct Assay

C

From MGI

GO:0050664

oxidoreductase activity, acting on NADH or NADPH, oxygen as acceptor

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_445976

F

From MGI

GO:0050667

homocysteine metabolic process

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q9NPH5

P

From MGI

GO:0051496

positive regulation of stress fiber assembly

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_445976

P

From MGI

GO:0051897

positive regulation of protein kinase B signaling cascade

MGI:MGI:5009390
PMID:17942966[3]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0055114

oxidation-reduction process

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0560

P

From MGI

GO:0055114

oxidation-reduction process

MGI:MGI:1930898
PMID:11098048[2]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0055114

oxidation-reduction process

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR000778
InterPro:IPR013112
InterPro:IPR017927
InterPro:IPR013121
InterPro:IPR017938

P

From MGI

GO:0055114

oxidation-reduction process

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q9NPH5

P

From MGI

GO:0055114

oxidation-reduction process

MGI:MGI:5009390
PMID:17942966[3]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0070374

positive regulation of ERK1 and ERK2 cascade

MGI:MGI:5009390
PMID:17942966[3]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0071944

cell periphery

MGI:MGI:3795840
PMID:18431508[5]

IDA: Inferred from Direct Assay

C

From MGI

GO:0072341

modified amino acid binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q9NPH5

F

From MGI

GO:0072593

reactive oxygen species metabolic process

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q9NPH5

P

From MGI

GO:0072593

reactive oxygen species metabolic process

MGI:MGI:5009390
PMID:17942966[3]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:2000379

positive regulation of reactive oxygen species metabolic process

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_445976

P

From MGI

GO:2000573

positive regulation of DNA biosynthetic process

MGI:MGI:5009390
PMID:17942966[3]

IMP: Inferred from Mutant Phenotype

P

From MGI

colocalizes_with

GO:0001725

stress fiber

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_445976

C

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 Geiszt, M et al. (2000) Identification of renox, an NAD(P)H oxidase in kidney. Proc. Natl. Acad. Sci. U.S.A. 97 8010-4 PubMed GONUTS page
  2. 2.0 2.1 2.2 Yang, S et al. (2001) A new superoxide-generating oxidase in murine osteoclasts. J. Biol. Chem. 276 5452-8 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Wagner, B et al. (2007) Mitogenic signaling via platelet-derived growth factor beta in metanephric mesenchymal cells. J. Am. Soc. Nephrol. 18 2903-11 PubMed GONUTS page
  4. Li, J et al. (2006) The NADPH oxidase NOX4 drives cardiac differentiation: Role in regulating cardiac transcription factors and MAP kinase activation. Mol. Biol. Cell 17 3978-88 PubMed GONUTS page
  5. 5.0 5.1 Sharma, K et al. (2008) Adiponectin regulates albuminuria and podocyte function in mice. J. Clin. Invest. 118 1645-56 PubMed GONUTS page
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