GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MGI:Nox4
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Nox4 | |
| Protein Name(s) | NADPH oxidase 4, | |
| External Links | ||
| MGI | MGI:1354184 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000902 |
cell morphogenesis |
MGI:MGI:3694159 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0005506 |
iron ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445976 |
C |
From MGI |
||
| GO:0005783 |
endoplasmic reticulum |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0256 |
C |
From MGI |
||
| GO:0005886 |
plasma membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-1003 |
C |
From MGI |
||
| GO:0005925 |
focal adhesion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445976 |
C |
From MGI |
||
| GO:0006801 |
superoxide metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445976 |
P |
From MGI |
||
| GO:0007569 |
cell aging |
MGI:MGI:3694159 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:3694159 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0009055 |
electron carrier activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0014911 |
positive regulation of smooth muscle cell migration |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445976 |
P |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0016174 |
NAD(P)H oxidase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445976 |
F |
From MGI |
||
| GO:0016175 |
superoxide-generating NADPH oxidase activity |
MGI:MGI:1930898 |
IMP: Inferred from Mutant Phenotype |
F |
From MGI |
|||
| GO:0016175 |
superoxide-generating NADPH oxidase activity |
MGI:MGI:5009390 |
IMP: Inferred from Mutant Phenotype |
F |
From MGI |
|||
| GO:0016324 |
apical plasma membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445976 |
C |
From MGI |
||
| GO:0016491 |
oxidoreductase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0560 |
F |
From MGI |
||
| GO:0016491 |
oxidoreductase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR000778 |
F |
From MGI |
||
| GO:0030054 |
cell junction |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0965 |
C |
From MGI |
||
| GO:0035051 |
cardiac cell differentiation |
MGI:MGI:3689176 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0042554 |
superoxide anion generation |
MGI:MGI:3694159 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0043020 |
NADPH oxidase complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445976 |
C |
From MGI |
||
| GO:0043065 |
positive regulation of apoptotic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445976 |
P |
From MGI |
||
| GO:0043406 |
positive regulation of MAP kinase activity |
MGI:MGI:5009390 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045453 |
bone resorption |
MGI:MGI:1930898 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0048471 |
perinuclear region of cytoplasm |
MGI:MGI:3795840 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0050660 |
flavin adenine dinucleotide binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0050664 |
oxidoreductase activity, acting on NADH or NADPH, oxygen as acceptor |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445976 |
F |
From MGI |
||
| GO:0050667 |
homocysteine metabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051496 |
positive regulation of stress fiber assembly |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445976 |
P |
From MGI |
||
| GO:0051897 |
positive regulation of protein kinase B signaling cascade |
MGI:MGI:5009390 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0055114 |
oxidation-reduction process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
MGI:MGI:5009390 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0071944 |
cell periphery |
MGI:MGI:3795840 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0072341 |
modified amino acid binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0072593 |
reactive oxygen species metabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0072593 |
reactive oxygen species metabolic process |
MGI:MGI:5009390 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:2000379 |
positive regulation of reactive oxygen species metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445976 |
P |
From MGI |
||
| GO:2000573 |
positive regulation of DNA biosynthetic process |
MGI:MGI:5009390 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
|
colocalizes_with |
GO:0001725 |
stress fiber |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_445976 |
C |
From MGI |
|
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Geiszt M et al. (2000) Identification of renox, an NAD(P)H oxidase in kidney. Proc Natl Acad Sci U S A 97: 8010-4 PubMed GONUTS page
- ↑ 2.0 2.1 Yang S et al. (2001) A new superoxide-generating oxidase in murine osteoclasts. J Biol Chem 276: 5452-8 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Wagner B et al. (2007) Mitogenic signaling via platelet-derived growth factor beta in metanephric mesenchymal cells. J Am Soc Nephrol 18: 2903-11 PubMed GONUTS page
- ↑ Li J et al. (2006) The NADPH oxidase NOX4 drives cardiac differentiation: Role in regulating cardiac transcription factors and MAP kinase activation. Mol Biol Cell 17: 3978-88 PubMed GONUTS page
- ↑ 5.0 5.1 Sharma K et al. (2008) Adiponectin regulates albuminuria and podocyte function in mice. J Clin Invest 118: 1645-56 PubMed GONUTS page
