GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MGI:Nos3
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Nos3 ( synonyms: ecNOS, eNOS, Nos-3 ) | |
| Protein Name(s) | nitric oxide synthase 3, endothelial cell, | |
| External Links | ||
| MGI | MGI:97362 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001525 |
angiogenesis |
MGI:MGI:3580728 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857229 |
P |
From MGI |
||
| GO:0001542 |
ovulation from ovarian follicle |
MGI:MGI:2157249 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2657240 |
P |
From MGI |
||
| GO:0001701 |
in utero embryonic development |
MGI:MGI:2157736 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0001974 |
blood vessel remodeling |
MGI:MGI:3702849 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0002028 |
regulation of sodium ion transport |
MGI:MGI:3686929 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2150145 |
P |
From MGI |
||
| GO:0003100 |
regulation of systemic arterial blood pressure by endothelin |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0003785 |
actin monomer binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004517 |
nitric-oxide synthase activity |
MGI:MGI:3576391 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857229 |
F |
From MGI |
||
| GO:0004517 |
nitric-oxide synthase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004517 |
nitric-oxide synthase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005506 |
iron ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005516 |
calmodulin binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0112 |
F |
From MGI |
||
| GO:0005516 |
calmodulin binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005625 |
soluble fraction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2157736 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005730 |
nucleolus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:2157736 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005856 |
cytoskeleton |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0206 |
C |
From MGI |
||
| GO:0005886 |
plasma membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-1003 |
C |
From MGI |
||
| GO:0005901 |
caveola |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006527 |
arginine catabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006809 |
nitric oxide biosynthetic process |
MGI:MGI:3576391 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857229 |
P |
From MGI |
||
| GO:0006809 |
nitric oxide biosynthetic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006809 |
nitric oxide biosynthetic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007165 |
signal transduction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:3702849 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0010181 |
FMN binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0012506 |
vesicle membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0014740 |
negative regulation of muscle hyperplasia |
MGI:MGI:3702849 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0014806 |
smooth muscle hyperplasia |
MGI:MGI:3702849 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016491 |
oxidoreductase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0560 |
F |
From MGI |
||
| GO:0016491 |
oxidoreductase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR003097 |
F |
From MGI |
||
| GO:0020037 |
heme binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030324 |
lung development |
MGI:MGI:3580728 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857229 |
P |
From MGI |
||
| GO:0031284 |
positive regulation of guanylate cyclase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031663 |
lipopolysaccharide-mediated signaling pathway |
MGI:MGI:3576391 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857229 |
P |
From MGI |
||
| GO:0032355 |
response to estradiol stimulus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0034617 |
tetrahydrobiopterin binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0034618 |
arginine binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043065 |
positive regulation of apoptotic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043267 |
negative regulation of potassium ion transport |
MGI:MGI:3686929 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2150145 |
P |
From MGI |
||
| GO:0043542 |
endothelial cell migration |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045177 |
apical part of cell |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045766 |
positive regulation of angiogenesis |
MGI:MGI:3807768 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0048662 |
negative regulation of smooth muscle cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050660 |
flavin adenine dinucleotide binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0050661 |
NADP binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0050880 |
regulation of blood vessel size |
MGI:MGI:3702849 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0051346 |
negative regulation of hydrolase activity |
MGI:MGI:3686929 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2150145 |
P |
From MGI |
||
| GO:0051879 |
Hsp90 protein binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0051926 |
negative regulation of calcium ion transport |
MGI:MGI:3686929 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2150145 |
P |
From MGI |
||
| GO:0071560 |
cellular response to transforming growth factor beta stimulus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Han RN et al. (2004) Defective lung vascular development and fatal respiratory distress in endothelial NO synthase-deficient mice: a model of alveolar capillary dysplasia? Circ Res 94: 1115-23 PubMed GONUTS page
- ↑ Hefler LA & Gregg AR (2002) Inducible and endothelial nitric oxide synthase: genetic background affects ovulation in mice. Fertil Steril 77: 147-51 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Nishikimi A et al. (2001) Localization of nitric oxide synthase activity in unfertilized oocytes and fertilized embryos during preimplantation development in mice. Reproduction 122: 957-63 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Rudic RD et al. (1998) Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling. J Clin Invest 101: 731-6 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Zhou L et al. (2002) Lack of nitric oxide synthase depresses ion transporting enzyme function in cardiac muscle. Biochem Biophys Res Commun 294: 1030-5 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Connelly L et al. (2005) Resistance to endotoxic shock in endothelial nitric-oxide synthase (eNOS) knock-out mice: a pro-inflammatory role for eNOS-derived no in vivo. J Biol Chem 280: 10040-6 PubMed GONUTS page
- ↑ Murohara T et al. (1998) Nitric oxide synthase modulates angiogenesis in response to tissue ischemia. J Clin Invest 101: 2567-78 PubMed GONUTS page
