MGI:Nodal

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:2138058 PMID:11456449^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0001701	in utero embryonic development	MGI:MGI:2155575 PMID:11311163^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158732	P	From MGI
	GO:0001701	in utero embryonic development	MGI:MGI:3511374 PMID:15485907^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2180793	P	From MGI
	GO:0001702	gastrulation with mouth forming second	MGI:MGI:3701544 PMID:14607953^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856970	P	From MGI
	GO:0001707	mesoderm formation	MGI:MGI:2155575 PMID:11311163^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158732	P	From MGI
	GO:0001829	trophectodermal cell differentiation	MGI:MGI:2138058 PMID:11456449^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0001831	trophectodermal cellular morphogenesis	MGI:MGI:2138058 PMID:11456449^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856970 MGI:MGI:2158730	P	From MGI
	GO:0001842	neural fold formation	MGI:MGI:2155575 PMID:11311163^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158732	P	From MGI
	GO:0001889	liver development	MGI:MGI:2155575 PMID:11311163^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158732	P	From MGI
	GO:0001892	embryonic placenta development	MGI:MGI:2138058 PMID:11456449^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856970 MGI:MGI:2158730	P	From MGI
	GO:0001944	vasculature development	MGI:MGI:2155575 PMID:11311163^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158732	P	From MGI
	GO:0001947	heart looping	MGI:MGI:3624254 PMID:16496285^[5]	IGI: Inferred from Genetic Interaction	MGI:MGI:106676	P	From MGI
	GO:0002085	inhibition of neuroepithelial cell differentiation	MGI:MGI:3640721 PMID:16678814^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2180793	P	From MGI
	GO:0005125	cytokine activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0202	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3042530 PMID:15062104^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q64280	F	From MGI
	GO:0005576	extracellular region	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0964	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0202	C	From MGI
	GO:0007179	transforming growth factor beta receptor signaling pathway	MGI:MGI:52474 PMID:8429908^[8]	ISA: Inferred from Sequence Alignment	UniProtKB:P04202	P	From MGI
	GO:0007275	multicellular organismal development	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0217	P	From MGI
	GO:0007368	determination of left/right symmetry	MGI:MGI:2155575 PMID:11311163^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158732	P	From MGI
	GO:0007368	determination of left/right symmetry	MGI:MGI:2387223 PMID:12231623^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2388004 MGI:MGI:2180793	P	From MGI
	GO:0007368	determination of left/right symmetry	MGI:MGI:2652200 PMID:12642485^[10]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007368	determination of left/right symmetry	MGI:MGI:2654412 PMID:12654299^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007368	determination of left/right symmetry	MGI:MGI:3055649 PMID:15466485^[12]	IGI: Inferred from Genetic Interaction	MGI:MGI:1344365	P	From MGI
	GO:0007368	determination of left/right symmetry	MGI:MGI:3624254 PMID:16496285^[5]	IGI: Inferred from Genetic Interaction	MGI:MGI:106676	P	From MGI
	GO:0007369	gastrulation	MGI:MGI:2155575 PMID:11311163^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158732	P	From MGI
	GO:0007369	gastrulation	MGI:MGI:2677178 PMID:14511481^[13]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0007399	nervous system development	MGI:MGI:2155575 PMID:11311163^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158732	P	From MGI
	GO:0007420	brain development	MGI:MGI:2155575 PMID:11311163^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158732	P	From MGI
	GO:0007492	endoderm development	MGI:MGI:2155575 PMID:11311163^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158732	P	From MGI
	GO:0007507	heart development	MGI:MGI:2155575 PMID:11311163^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158732	P	From MGI
	GO:0008083	growth factor activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0339	F	From MGI
	GO:0008083	growth factor activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001839 InterPro:IPR001111 InterPro:IPR017948	F	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:3042338 PMID:15004567^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2180793	P	From MGI
	GO:0009880	embryonic pattern specification	MGI:MGI:2155575 PMID:11311163^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158732	P	From MGI
	GO:0009948	anterior/posterior axis specification	MGI:MGI:2155575 PMID:11311163^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158732	P	From MGI
	GO:0009952	anterior/posterior pattern specification	MGI:MGI:2136068 PMID:11418863^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2180793	P	From MGI
	GO:0009952	anterior/posterior pattern specification	MGI:MGI:2155575 PMID:11311163^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158732	P	From MGI
	GO:0009952	anterior/posterior pattern specification	MGI:MGI:3042338 PMID:15004567^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2180793	P	From MGI
	GO:0009952	anterior/posterior pattern specification	MGI:MGI:3056019 PMID:15302604^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3056345 MGI:MGI:2656539	P	From MGI
	GO:0009952	anterior/posterior pattern specification	MGI:MGI:3624254 PMID:16496285^[5]	IGI: Inferred from Genetic Interaction	MGI:MGI:106676	P	From MGI
	GO:0009966	regulation of signal transduction	MGI:MGI:3763867 PMID:17936261^[17]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0010085	polarity specification of proximal/distal axis	MGI:MGI:2677178 PMID:14511481^[13]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0016477	cell migration	MGI:MGI:3056019 PMID:15302604^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3056345 MGI:MGI:2176174	P	From MGI
	GO:0019827	stem cell maintenance	MGI:MGI:3057068 PMID:15505202^[18]	IGI: Inferred from Genetic Interaction	MGI:MGI:95518	P	From MGI
	GO:0019827	stem cell maintenance	MGI:MGI:3640721 PMID:16678814^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2180793	P	From MGI
	GO:0030324	lung development	MGI:MGI:2155575 PMID:11311163^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158732	P	From MGI
	GO:0033505	floor plate morphogenesis	MGI:MGI:2155575 PMID:11311163^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158732	P	From MGI
	GO:0035050	embryonic heart tube development	MGI:MGI:2155575 PMID:11311163^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158732	P	From MGI
	GO:0040007	growth	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001111	P	From MGI
	GO:0042074	cell migration involved in gastrulation	MGI:MGI:3042338 PMID:15004567^[14]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045165	cell fate commitment	MGI:MGI:2667288 PMID:12842913^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2668418	P	From MGI
	GO:0045596	negative regulation of cell differentiation	MGI:MGI:2138058 PMID:11456449^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3716271 PMID:17568773^[20]	IGI: Inferred from Genetic Interaction	MGI:MGI:98658 MGI:MGI:1347465	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:5315339 PMID:17507406^[21]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0048327	axial mesodermal cell fate specification	MGI:MGI:2677178 PMID:14511481^[13]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0048382	mesendoderm development	MGI:MGI:2155575 PMID:11311163^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158732	P	From MGI
	GO:0048382	mesendoderm development	MGI:MGI:2677178 PMID:14511481^[13]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0048546	digestive tract morphogenesis	MGI:MGI:2155575 PMID:11311163^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158732	P	From MGI
	GO:0048646	anatomical structure formation involved in morphogenesis	MGI:MGI:67405 PMID:7924997^[22]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856970	P	From MGI
	GO:0048701	embryonic cranial skeleton morphogenesis	MGI:MGI:2155575 PMID:11311163^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158732	P	From MGI
	GO:0048729	tissue morphogenesis	MGI:MGI:2155575 PMID:11311163^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158732	P	From MGI
	GO:0048859	formation of anatomical boundary	MGI:MGI:2155575 PMID:11311163^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158732	P	From MGI
	GO:0055123	digestive system development	MGI:MGI:2155575 PMID:11311163^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158732	P	From MGI
	GO:0060136	embryonic process involved in female pregnancy	MGI:MGI:2138058 PMID:11456449^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856970 MGI:MGI:2158730	P	From MGI
	GO:0060395	SMAD protein signal transduction	MGI:MGI:1195384 PMID:9420335^[23]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0060460	left lung morphogenesis	MGI:MGI:2155575 PMID:11311163^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158732	P	From MGI
	GO:0060802	epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification	MGI:MGI:2677178 PMID:14511481^[13]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0090009	primitive streak formation	MGI:MGI:4950786 PMID:21445260^[24]	IGI: Inferred from Genetic Interaction	MGI:MGI:96086	P	From MGI
	GO:0090010	transforming growth factor beta receptor signaling pathway involved in primitive streak formation	MGI:MGI:2677178 PMID:14511481^[13]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:1900164	nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry	MGI:MGI:5315339 PMID:17507406^[21]	IMP: Inferred from Mutant Phenotype		P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Ma GT et al. (2001) Nodal regulates trophoblast differentiation and placental development. Dev Biol 236: 124-35 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 ^2.16 ^2.17 ^2.18 ^2.19 ^2.20 ^2.21 ^2.22 ^2.23 Lowe LA et al. (2001) Genetic dissection of nodal function in patterning the mouse embryo. Development 128: 1831-43 PubMed GONUTS page
↑ Jörnvall H et al. (2004) ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse. Mol Cell Biol 24: 9383-9 PubMed GONUTS page
↑ Huaux F et al. (2003) Eosinophils and T lymphocytes possess distinct roles in bleomycin-induced lung injury and fibrosis. J Immunol 171: 5470-81 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Ware SM et al. (2006) Heart defects in X-linked heterotaxy: evidence for a genetic interaction of Zic3 with the nodal signaling pathway. Dev Dyn 235: 1631-7 PubMed GONUTS page
↑ ^6.0 ^6.1 Camus A et al. (2006) Absence of Nodal signaling promotes precocious neural differentiation in the mouse embryo. Dev Biol 295: 743-55 PubMed GONUTS page
↑ Chen C & Shen MM (2004) Two modes by which Lefty proteins inhibit nodal signaling. Curr Biol 14: 618-24 PubMed GONUTS page
↑ Zhou X et al. (1993) Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation. Nature 361: 543-7 PubMed GONUTS page
↑ Brennan J et al. (2002) Nodal activity in the node governs left-right asymmetry. Genes Dev 16: 2339-44 PubMed GONUTS page
↑ Yamamoto M et al. (2003) Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate. Development 130: 1795-804 PubMed GONUTS page
↑ Saijoh Y et al. (2003) Left-right patterning of the mouse lateral plate requires nodal produced in the node. Dev Biol 256: 160-72 PubMed GONUTS page
↑ Marques S et al. (2004) The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis. Genes Dev 18: 2342-7 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Robertson EJ et al. (2003) Control of early anterior-posterior patterning in the mouse embryo by TGF-beta signalling. Philos Trans R Soc Lond B Biol Sci 358: 1351-7; discussion 1357 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Yamamoto M et al. (2004) Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo. Nature 428: 387-92 PubMed GONUTS page
↑ Brennan J et al. (2001) Nodal signalling in the epiblast patterns the early mouse embryo. Nature 411: 965-9 PubMed GONUTS page
↑ ^16.0 ^16.1 Lu CC & Robertson EJ (2004) Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior patterning. Dev Biol 273: 149-59 PubMed GONUTS page
↑ Andersson O et al. (2007) Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development. Dev Biol 311: 500-11 PubMed GONUTS page
↑ Guzman-Ayala M et al. (2004) Nodal protein processing and fibroblast growth factor 4 synergize to maintain a trophoblast stem cell microenvironment. Proc Natl Acad Sci U S A 101: 15656-60 PubMed GONUTS page
↑ Vincent SD et al. (2003) Cell fate decisions within the mouse organizer are governed by graded Nodal signals. Genes Dev 17: 1646-62 PubMed GONUTS page
↑ Izzi L et al. (2007) Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development. EMBO J 26: 3132-43 PubMed GONUTS page
↑ ^21.0 ^21.1 Tavares AT et al. (2007) Cerberus is a feedback inhibitor of Nodal asymmetric signaling in the chick embryo. Development 134: 2051-60 PubMed GONUTS page
↑ Conlon FL et al. (1994) A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse. Development 120: 1919-28 PubMed GONUTS page
↑ Sirard C et al. (1998) The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev 12: 107-19 PubMed GONUTS page
↑ Stuckey DW et al. (2011) Correct patterning of the primitive streak requires the anterior visceral endoderm. PLoS One 6: e17620 PubMed GONUTS page

[PMID:11456449-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Ma GT et al. (2001) Nodal regulates trophoblast differentiation and placental development. Dev Biol 236: 124-35 PubMed GONUTS page

[PMID:11311163-1] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 ^2.16 ^2.17 ^2.18 ^2.19 ^2.20 ^2.21 ^2.22 ^2.23 Lowe LA et al. (2001) Genetic dissection of nodal function in patterning the mouse embryo. Development 128: 1831-43 PubMed GONUTS page

[PMID:15485907-2] Jörnvall H et al. (2004) ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse. Mol Cell Biol 24: 9383-9 PubMed GONUTS page

[PMID:14607953-3] Huaux F et al. (2003) Eosinophils and T lymphocytes possess distinct roles in bleomycin-induced lung injury and fibrosis. J Immunol 171: 5470-81 PubMed GONUTS page

[PMID:16496285-4] 5.0 ^5.1 ^5.2 Ware SM et al. (2006) Heart defects in X-linked heterotaxy: evidence for a genetic interaction of Zic3 with the nodal signaling pathway. Dev Dyn 235: 1631-7 PubMed GONUTS page

[PMID:16678814-5] 6.0 ^6.1 Camus A et al. (2006) Absence of Nodal signaling promotes precocious neural differentiation in the mouse embryo. Dev Biol 295: 743-55 PubMed GONUTS page

[PMID:15062104-6] Chen C & Shen MM (2004) Two modes by which Lefty proteins inhibit nodal signaling. Curr Biol 14: 618-24 PubMed GONUTS page

[PMID:8429908-7] Zhou X et al. (1993) Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation. Nature 361: 543-7 PubMed GONUTS page

[PMID:12231623-8] Brennan J et al. (2002) Nodal activity in the node governs left-right asymmetry. Genes Dev 16: 2339-44 PubMed GONUTS page

[PMID:12642485-9] Yamamoto M et al. (2003) Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate. Development 130: 1795-804 PubMed GONUTS page

[PMID:12654299-10] Saijoh Y et al. (2003) Left-right patterning of the mouse lateral plate requires nodal produced in the node. Dev Biol 256: 160-72 PubMed GONUTS page

[PMID:15466485-11] Marques S et al. (2004) The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis. Genes Dev 18: 2342-7 PubMed GONUTS page

[PMID:14511481-12] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Robertson EJ et al. (2003) Control of early anterior-posterior patterning in the mouse embryo by TGF-beta signalling. Philos Trans R Soc Lond B Biol Sci 358: 1351-7; discussion 1357 PubMed GONUTS page

[PMID:15004567-13] 14.0 ^14.1 ^14.2 Yamamoto M et al. (2004) Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo. Nature 428: 387-92 PubMed GONUTS page

[PMID:11418863-14] Brennan J et al. (2001) Nodal signalling in the epiblast patterns the early mouse embryo. Nature 411: 965-9 PubMed GONUTS page

[PMID:15302604-15] 16.0 ^16.1 Lu CC & Robertson EJ (2004) Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior patterning. Dev Biol 273: 149-59 PubMed GONUTS page

[PMID:17936261-16] Andersson O et al. (2007) Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development. Dev Biol 311: 500-11 PubMed GONUTS page

[PMID:15505202-17] Guzman-Ayala M et al. (2004) Nodal protein processing and fibroblast growth factor 4 synergize to maintain a trophoblast stem cell microenvironment. Proc Natl Acad Sci U S A 101: 15656-60 PubMed GONUTS page

[PMID:12842913-18] Vincent SD et al. (2003) Cell fate decisions within the mouse organizer are governed by graded Nodal signals. Genes Dev 17: 1646-62 PubMed GONUTS page

[PMID:17568773-19] Izzi L et al. (2007) Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development. EMBO J 26: 3132-43 PubMed GONUTS page

[PMID:17507406-20] 21.0 ^21.1 Tavares AT et al. (2007) Cerberus is a feedback inhibitor of Nodal asymmetric signaling in the chick embryo. Development 134: 2051-60 PubMed GONUTS page

[PMID:7924997-21] Conlon FL et al. (1994) A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse. Development 120: 1919-28 PubMed GONUTS page

[PMID:9420335-22] Sirard C et al. (1998) The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev 12: 107-19 PubMed GONUTS page

[PMID:21445260-23] Stuckey DW et al. (2011) Correct patterning of the primitive streak requires the anterior visceral endoderm. PLoS One 6: e17620 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Nodal ( synonyms: Tg.413d )
Protein Name(s)	nodal,
External Links
MGI	MGI:97359

MGI:Nodal

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