MGI:Nod2

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000166	nucleotide binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0547	F	From MGI
	GO:0002227	innate immune response in mucosa	MGI:MGI:3528786 PMID:15692051^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3529594	P	From MGI
	GO:0002253	activation of immune response	MGI:MGI:3528786 PMID:15692051^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3529594	P	From MGI
	GO:0002282	microglial cell activation involved in immune response	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001099642	P	From MGI
	GO:0002367	cytokine production involved in immune response	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9HC29	P	From MGI
	GO:0002381	immunoglobulin production involved in immunoglobulin mediated immune response	MGI:MGI:3528786 PMID:15692051^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3529594	P	From MGI
	GO:0002606	positive regulation of dendritic cell antigen processing and presentation	MGI:MGI:4442557 PMID:20008287^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0002710	negative regulation of T cell mediated immunity	MGI:MGI:3686795 PMID:16949315^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2680581	P	From MGI
	GO:0002732	positive regulation of dendritic cell cytokine production	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001099642	P	From MGI
	GO:0002830	positive regulation of type 2 immune response	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9HC29	P	From MGI
	GO:0002862	negative regulation of inflammatory response to antigenic stimulus	MGI:MGI:3686795 PMID:16949315^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2680581	P	From MGI
	GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin	MGI:MGI:3528786 PMID:15692051^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3529594	P	From MGI
	GO:0005515	protein binding	MGI:MGI:3697751 PMID:17187069^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q6P065	F	From MGI
	GO:0005515	protein binding	MGI:MGI:4943384 PMID:18511561^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q67EY4	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0067	F	From MGI
	GO:0005622	intracellular	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001315	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:3689793 PMID:15967716^[6]	TAS: Traceable Author Statement		C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001099642	C	From MGI
	GO:0005829	cytosol	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9HC29	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9HC29	C	From MGI
	GO:0006952	defense response	MGI:MGI:3689793 PMID:15967716^[6]	TAS: Traceable Author Statement		P	From MGI
	GO:0006954	inflammatory response	MGI:MGI:3689793 PMID:15967716^[6]	TAS: Traceable Author Statement		P	From MGI
	GO:0006965	positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria	MGI:MGI:3528786 PMID:15692051^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3529594	P	From MGI
	GO:0007165	signal transduction	MGI:MGI:3689793 PMID:15967716^[6]	TAS: Traceable Author Statement		P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001099642	P	From MGI
	GO:0009595	detection of biotic stimulus	MGI:MGI:3689793 PMID:15967716^[6]	TAS: Traceable Author Statement		P	From MGI
	GO:0009986	cell surface	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9HC29	C	From MGI
	GO:0016045	detection of bacterium	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9HC29	P	From MGI
	GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR018228	F	From MGI
	GO:0019899	enzyme binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9HC29	F	From MGI
	GO:0019901	protein kinase binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9HC29	F	From MGI
	GO:0031398	positive regulation of protein ubiquitination	MGI:MGI:4441121 PMID:15620648^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0031982	vesicle	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9HC29	C	From MGI
	GO:0032088	negative regulation of NF-kappaB transcription factor activity	MGI:MGI:3050756 PMID:15220916^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2680581	P	From MGI
	GO:0032494	response to peptidoglycan	MGI:MGI:3050756 PMID:15220916^[8]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0032494	response to peptidoglycan	MGI:MGI:3050756 PMID:15220916^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2680581	P	From MGI
	GO:0032495	response to muramyl dipeptide	MGI:MGI:2679172 PMID:14560001^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2680581	P	From MGI
	GO:0032495	response to muramyl dipeptide	MGI:MGI:3050756 PMID:15220916^[8]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0032495	response to muramyl dipeptide	MGI:MGI:3050756 PMID:15220916^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2680581	P	From MGI
	GO:0032495	response to muramyl dipeptide	MGI:MGI:3528786 PMID:15692051^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3529594	P	From MGI
	GO:0032495	response to muramyl dipeptide	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001099642	P	From MGI
	GO:0032495	response to muramyl dipeptide	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9HC29	P	From MGI
	GO:0032495	response to muramyl dipeptide	MGI:MGI:4943384 PMID:18511561^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0032496	response to lipopolysaccharide	MGI:MGI:2679172 PMID:14560001^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2680581	P	From MGI
	GO:0032496	response to lipopolysaccharide	MGI:MGI:3528786 PMID:15692051^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3529594	P	From MGI
	GO:0032498	detection of muramyl dipeptide	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:Q9HC29	P	From MGI
	GO:0032500	muramyl dipeptide binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001099642	F	From MGI
	GO:0032500	muramyl dipeptide binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9HC29	F	From MGI
	GO:0032689	negative regulation of interferon-gamma production	MGI:MGI:3050756 PMID:15220916^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2680581	P	From MGI
	GO:0032689	negative regulation of interferon-gamma production	MGI:MGI:3839525 PMID:19139201^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3529594	P	From MGI
	GO:0032695	negative regulation of interleukin-12 production	MGI:MGI:3050756 PMID:15220916^[8]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0032695	negative regulation of interleukin-12 production	MGI:MGI:3050756 PMID:15220916^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2680581	P	From MGI
	GO:0032695	negative regulation of interleukin-12 production	MGI:MGI:3686795 PMID:16949315^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2680581	P	From MGI
	GO:0032701	negative regulation of interleukin-18 production	MGI:MGI:3050756 PMID:15220916^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2680581	P	From MGI
	GO:0032703	negative regulation of interleukin-2 production	MGI:MGI:3839525 PMID:19139201^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3529594	P	From MGI
	GO:0032720	negative regulation of tumor necrosis factor production	MGI:MGI:3839525 PMID:19139201^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3529594	P	From MGI
	GO:0032731	positive regulation of interleukin-1 beta production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9HC29	P	From MGI
	GO:0032733	positive regulation of interleukin-10 production	MGI:MGI:4946442 PMID:21156799^[11]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0032735	positive regulation of interleukin-12 production	MGI:MGI:2679172 PMID:14560001^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2680581	P	From MGI
	GO:0032735	positive regulation of interleukin-12 production	MGI:MGI:3050756 PMID:15220916^[8]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0032735	positive regulation of interleukin-12 production	MGI:MGI:3050756 PMID:15220916^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2680581	P	From MGI
	GO:0032735	positive regulation of interleukin-12 production	MGI:MGI:3528786 PMID:15692051^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3529594	P	From MGI
	GO:0032740	positive regulation of interleukin-17 production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9HC29	P	From MGI
	GO:0032755	positive regulation of interleukin-6 production	MGI:MGI:3528786 PMID:15692051^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3529594	P	From MGI
	GO:0032755	positive regulation of interleukin-6 production	MGI:MGI:3775161 PMID:18261938^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0032755	positive regulation of interleukin-6 production	MGI:MGI:3775161 PMID:18261938^[12]	IGI: Inferred from Genetic Interaction	MGI:MGI:1341839	P	From MGI
	GO:0032755	positive regulation of interleukin-6 production	MGI:MGI:3775161 PMID:18261938^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3529594	P	From MGI
	GO:0032755	positive regulation of interleukin-6 production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9HC29	P	From MGI
	GO:0032760	positive regulation of tumor necrosis factor production	MGI:MGI:3050756 PMID:15220916^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2680581	P	From MGI
	GO:0032760	positive regulation of tumor necrosis factor production	MGI:MGI:3697751 PMID:17187069^[4]	ISO: Inferred from Sequence Orthology	UniProtKB:Q9HC29	P	From MGI
	GO:0032760	positive regulation of tumor necrosis factor production	MGI:MGI:3775161 PMID:18261938^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0032760	positive regulation of tumor necrosis factor production	MGI:MGI:3775161 PMID:18261938^[12]	IGI: Inferred from Genetic Interaction	MGI:MGI:1341839	P	From MGI
	GO:0032760	positive regulation of tumor necrosis factor production	MGI:MGI:3775161 PMID:18261938^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3529594	P	From MGI
	GO:0032760	positive regulation of tumor necrosis factor production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9HC29	P	From MGI
	GO:0032874	positive regulation of stress-activated MAPK cascade	MGI:MGI:3697751 PMID:17187069^[4]	ISO: Inferred from Sequence Orthology	UniProtKB:Q9HC29	P	From MGI
	GO:0032874	positive regulation of stress-activated MAPK cascade	MGI:MGI:3775161 PMID:18261938^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0034136	negative regulation of toll-like receptor 2 signaling pathway	MGI:MGI:3050756 PMID:15220916^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2680581	P	From MGI
	GO:0035419	activation of MAPK activity involved in innate immune response	MGI:MGI:4946442 PMID:21156799^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0035556	intracellular signal transduction	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9HC29	P	From MGI
	GO:0042742	defense response to bacterium	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001099642	P	From MGI
	GO:0042742	defense response to bacterium	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9HC29	P	From MGI
	GO:0042834	peptidoglycan binding	MGI:MGI:3689793 PMID:15967716^[6]	TAS: Traceable Author Statement		F	From MGI
	GO:0042834	peptidoglycan binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9HC29	F	From MGI
	GO:0042981	regulation of apoptotic process	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001315	P	From MGI
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:Q9HC29	P	From MGI
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	MGI:MGI:3775161 PMID:18261938^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0043330	response to exogenous dsRNA	MGI:MGI:3528786 PMID:15692051^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3529594	P	From MGI
	GO:0043410	positive regulation of MAPK cascade	MGI:MGI:3528786 PMID:15692051^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3529594	P	From MGI
	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	MGI:MGI:4946442 PMID:21156799^[11]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0044130	negative regulation of growth of symbiont in host	MGI:MGI:3839525 PMID:19139201^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3529594	P	From MGI
	GO:0045089	positive regulation of innate immune response	MGI:MGI:3528786 PMID:15692051^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3529594	P	From MGI
	GO:0045747	positive regulation of Notch signaling pathway	MGI:MGI:4946442 PMID:21156799^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0046330	positive regulation of JNK cascade	MGI:MGI:3697751 PMID:17187069^[4]	ISO: Inferred from Sequence Orthology	UniProtKB:Q9HC29	P	From MGI
	GO:0046330	positive regulation of JNK cascade	MGI:MGI:3775161 PMID:18261938^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0050679	positive regulation of epithelial cell proliferation	MGI:MGI:4943376 PMID:18855982^[13]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0050700	CARD domain binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9HC29	F	From MGI
	GO:0050718	positive regulation of interleukin-1 beta secretion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9HC29	P	From MGI
	GO:0050718	positive regulation of interleukin-1 beta secretion	MGI:MGI:4943384 PMID:18511561^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	MGI:MGI:3528786 PMID:15692051^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3529594	P	From MGI
	GO:0050766	positive regulation of phagocytosis	MGI:MGI:3839525 PMID:19139201^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3529594	P	From MGI
	GO:0050830	defense response to Gram-positive bacterium	MGI:MGI:3528786 PMID:15692051^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3529594	P	From MGI
	GO:0050830	defense response to Gram-positive bacterium	MGI:MGI:3775161 PMID:18261938^[12]	IGI: Inferred from Genetic Interaction	MGI:MGI:1341839	P	From MGI
	GO:0050830	defense response to Gram-positive bacterium	MGI:MGI:3775161 PMID:18261938^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3529594	P	From MGI
	GO:0050830	defense response to Gram-positive bacterium	MGI:MGI:3839525 PMID:19139201^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3529594	P	From MGI
	GO:0050871	positive regulation of B cell activation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9HC29	P	From MGI
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:Q9HC29	P	From MGI
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	MGI:MGI:3050756 PMID:15220916^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2680581	P	From MGI
	GO:0051259	protein oligomerization	MGI:MGI:3689793 PMID:15967716^[6]	TAS: Traceable Author Statement		P	From MGI
	GO:0051353	positive regulation of oxidoreductase activity	MGI:MGI:4946442 PMID:21156799^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	MGI:MGI:4946442 PMID:21156799^[11]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0052033	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001099642	P	From MGI
	GO:0060585	positive regulation of prostaglandin-endoperoxide synthase activity	MGI:MGI:4946442 PMID:21156799^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0070374	positive regulation of ERK1 and ERK2 cascade	MGI:MGI:3775161 PMID:18261938^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0070374	positive regulation of ERK1 and ERK2 cascade	MGI:MGI:4946442 PMID:21156799^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:Q9HC29	P	From MGI
	GO:0071224	cellular response to peptidoglycan	MGI:MGI:3686795 PMID:16949315^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2680581	P	From MGI
	GO:0071608	macrophage inflammatory protein-1 alpha production	MGI:MGI:3839525 PMID:19139201^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3529594	P	From MGI
	GO:0090022	regulation of neutrophil chemotaxis	MGI:MGI:3839525 PMID:19139201^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3529594	P	From MGI
	GO:0090305	nucleic acid phosphodiester bond hydrolysis	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR018228	P	From MGI
	GO:2000110	negative regulation of macrophage apoptotic process	MGI:MGI:4946442 PMID:21156799^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:2000363	positive regulation of prostaglandin-E synthase activity	MGI:MGI:4946442 PMID:21156799^[11]	IDA: Inferred from Direct Assay		P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 Kobayashi KS et al. (2005) Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307: 731-4 PubMed GONUTS page
↑ Asano J et al. (2010) Nucleotide oligomerization binding domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo. J Immunol 184: 736-45 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Watanabe T et al. (2006) Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis. Immunity 25: 473-85 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Hsu YM et al. (2007) The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat Immunol 8: 198-205 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Hsu LC et al. (2008) A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide. Proc Natl Acad Sci U S A 105: 7803-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Martinon F & Tschopp J (2005) NLRs join TLRs as innate sensors of pathogens. Trends Immunol 26: 447-54 PubMed GONUTS page
↑ Abbott DW et al. (2004) The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO. Curr Biol 14: 2217-27 PubMed GONUTS page
↑ ^8.00 ^8.01 ^8.02 ^8.03 ^8.04 ^8.05 ^8.06 ^8.07 ^8.08 ^8.09 ^8.10 ^8.11 ^8.12 ^8.13 Watanabe T et al. (2004) NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat Immunol 5: 800-8 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Pauleau AL & Murray PJ (2003) Role of nod2 in the response of macrophages to toll-like receptor agonists. Mol Cell Biol 23: 7531-9 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 Deshmukh HS et al. (2009) Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. Infect Immun 77: 1376-82 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 ^11.8 ^11.9 Bansal K & Balaji KN (2011) Intracellular pathogen sensor NOD2 programs macrophages to trigger Notch1 activation. J Biol Chem 286: 5823-35 PubMed GONUTS page
↑ ^12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 Kim YG et al. (2008) The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity 28: 246-57 PubMed GONUTS page
↑ Cruickshank SM et al. (2008) Evidence for the involvement of NOD2 in regulating colonic epithelial cell growth and survival. World J Gastroenterol 14: 5834-41 PubMed GONUTS page

[PMID:15692051-0] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 Kobayashi KS et al. (2005) Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307: 731-4 PubMed GONUTS page

[PMID:20008287-1] Asano J et al. (2010) Nucleotide oligomerization binding domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo. J Immunol 184: 736-45 PubMed GONUTS page

[PMID:16949315-2] 3.0 ^3.1 ^3.2 ^3.3 Watanabe T et al. (2006) Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis. Immunity 25: 473-85 PubMed GONUTS page

[PMID:17187069-3] 4.0 ^4.1 ^4.2 ^4.3 Hsu YM et al. (2007) The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat Immunol 8: 198-205 PubMed GONUTS page

[PMID:18511561-4] 5.0 ^5.1 ^5.2 Hsu LC et al. (2008) A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide. Proc Natl Acad Sci U S A 105: 7803-8 PubMed GONUTS page

[PMID:15967716-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Martinon F & Tschopp J (2005) NLRs join TLRs as innate sensors of pathogens. Trends Immunol 26: 447-54 PubMed GONUTS page

[PMID:15620648-6] Abbott DW et al. (2004) The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO. Curr Biol 14: 2217-27 PubMed GONUTS page

[PMID:15220916-7] 8.00 ^8.01 ^8.02 ^8.03 ^8.04 ^8.05 ^8.06 ^8.07 ^8.08 ^8.09 ^8.10 ^8.11 ^8.12 ^8.13 Watanabe T et al. (2004) NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat Immunol 5: 800-8 PubMed GONUTS page

[PMID:14560001-8] 9.0 ^9.1 ^9.2 Pauleau AL & Murray PJ (2003) Role of nod2 in the response of macrophages to toll-like receptor agonists. Mol Cell Biol 23: 7531-9 PubMed GONUTS page

[PMID:19139201-9] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 Deshmukh HS et al. (2009) Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. Infect Immun 77: 1376-82 PubMed GONUTS page

[PMID:21156799-10] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 ^11.8 ^11.9 Bansal K & Balaji KN (2011) Intracellular pathogen sensor NOD2 programs macrophages to trigger Notch1 activation. J Biol Chem 286: 5823-35 PubMed GONUTS page

[PMID:18261938-11] 12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 Kim YG et al. (2008) The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity 28: 246-57 PubMed GONUTS page

[PMID:18855982-12] Cruickshank SM et al. (2008) Evidence for the involvement of NOD2 in regulating colonic epithelial cell growth and survival. World J Gastroenterol 14: 5834-41 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Nod2 ( synonyms: Card15, Nlrc2 )
Protein Name(s)	nucleotide-binding oligomerization domain containing 2,
External Links
MGI	MGI:2429397

MGI:Nod2

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