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MGI:Nkx6-2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Nkx6-2 ( synonyms: Gtx, Nkx6.2 ) | |
| Protein Name(s) | NK6 homeobox 2, | |
| External Links | ||
| MGI | MGI:1352738 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:52878 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0238 |
F |
From MGI |
||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:52878 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2150481 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
RefSeq:XP_001068954 |
C |
From MGI |
||
| GO:0010454 |
negative regulation of cell fate commitment |
MGI:MGI:2150481 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2651850 |
P |
From MGI |
||
| GO:0010455 |
positive regulation of cell fate commitment |
MGI:MGI:2150481 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2651850 |
P |
From MGI |
||
| GO:0021912 |
regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification |
MGI:MGI:2150481 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1206039 |
P |
From MGI |
||
| GO:0021913 |
regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification |
MGI:MGI:2150481 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2651850 |
P |
From MGI |
||
| GO:0022010 |
central nervous system myelination |
MGI:MGI:3521547 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3522433 |
P |
From MGI |
||
| GO:0030154 |
cell differentiation |
MGI:MGI:3579924 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1206039 |
P |
From MGI |
||
| GO:0031018 |
endocrine pancreas development |
MGI:MGI:3579924 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1206039 |
P |
From MGI |
||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:52878 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0045686 |
negative regulation of glial cell differentiation |
MGI:MGI:3578466 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1206039 |
P |
From MGI |
||
| GO:0045687 |
positive regulation of glial cell differentiation |
MGI:MGI:3578466 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1206039 |
P |
From MGI |
||
| GO:0048709 |
oligodendrocyte differentiation |
MGI:MGI:3527370 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1206039 |
P |
From MGI |
||
| GO:0050885 |
neuromuscular process controlling balance |
MGI:MGI:3521547 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3522433 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Komuro I et al. (1993) Gtx: a novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter. EMBO J 12: 1387-401 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Vallstedt A et al. (2001) Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification. Neuron 31: 743-55 PubMed GONUTS page
- ↑ 3.0 3.1 Southwood C et al. (2004) CNS myelin paranodes require Nkx6-2 homeoprotein transcriptional activity for normal structure. J Neurosci 24: 11215-25 PubMed GONUTS page
- ↑ 4.0 4.1 Henseleit KD et al. (2005) NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas. Development 132: 3139-49 PubMed GONUTS page
- ↑ 5.0 5.1 Vallstedt A et al. (2005) Multiple dorsoventral origins of oligodendrocyte generation in the spinal cord and hindbrain. Neuron 45: 55-67 PubMed GONUTS page
- ↑ Cai J et al. (2005) Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of Nkx6 regulation and Shh signaling. Neuron 45: 41-53 PubMed GONUTS page
