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MGI:Ngfr
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Ngfr ( synonyms: LNGFR, p75, p75 neurotrophin receptor, p75NGFR, p75NTR, Tnfrsf16 ) | |
| Protein Name(s) | nerve growth factor receptor (TNFR superfamily, member 16), | |
| External Links | ||
| MGI | MGI:97323 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001540 |
beta-amyloid binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0005035 |
death receptor activity |
MGI:MGI:1859527 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005168 |
neurotrophin TRKA receptor binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2157219 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3586399 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005635 |
nuclear envelope |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3850905 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005791 |
rough endoplasmic reticulum |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:1346238 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006917 |
induction of apoptosis |
MGI:MGI:1859527 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006917 |
induction of apoptosis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007165 |
signal transduction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007411 |
axon guidance |
MGI:MGI:2178912 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857226 |
P |
From MGI |
||
| GO:0007417 |
central nervous system development |
MGI:MGI:2178912 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857226 |
P |
From MGI |
||
| GO:0009611 |
response to wounding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0010468 |
regulation of gene expression |
MGI:MGI:1350519 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857226 |
P |
From MGI |
||
| GO:0010942 |
positive regulation of cell death |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010977 |
negative regulation of neuron projection development |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016048 |
detection of temperature stimulus |
MGI:MGI:1098517 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857226 |
P |
From MGI |
||
| GO:0019233 |
sensory perception of pain |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0021675 |
nerve development |
MGI:MGI:1098517 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857226 |
P |
From MGI |
||
| GO:0030135 |
coated vesicle |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0031069 |
hair follicle morphogenesis |
MGI:MGI:1350519 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857226 |
P |
From MGI |
||
| GO:0031643 |
positive regulation of myelination |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032224 |
positive regulation of synaptic transmission, cholinergic |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032590 |
dendrite membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0032809 |
neuronal cell body membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0034599 |
cellular response to oxidative stress |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0035025 |
positive regulation of Rho protein signal transduction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0040037 |
negative regulation of fibroblast growth factor receptor signaling pathway |
MGI:MGI:1350519 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857226 |
P |
From MGI |
||
| GO:0042488 |
positive regulation of odontogenesis of dentin-containing tooth |
MGI:MGI:895167 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857226 |
P |
From MGI |
||
| GO:0043065 |
positive regulation of apoptotic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043121 |
neurotrophin binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043204 |
perikaryon |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043410 |
positive regulation of MAPK cascade |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043524 |
negative regulation of neuron apoptotic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043525 |
positive regulation of neuron apoptotic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043588 |
skin development |
MGI:MGI:1098517 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857226 |
P |
From MGI |
||
| GO:0045121 |
membrane raft |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045334 |
clathrin-coated endocytic vesicle |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0048146 |
positive regulation of fibroblast proliferation |
MGI:MGI:1350519 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857226 |
P |
From MGI |
||
| GO:0048406 |
nerve growth factor binding |
MGI:MGI:1098517 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0048406 |
nerve growth factor binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0051799 |
negative regulation of hair follicle development |
MGI:MGI:1350519 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857226 |
P |
From MGI |
||
| GO:0051897 |
positive regulation of protein kinase B signaling cascade |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051902 |
negative regulation of mitochondrial depolarization |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051968 |
positive regulation of synaptic transmission, glutamatergic |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060548 |
negative regulation of cell death |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070678 |
preprotein binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:2000377 |
regulation of reactive oxygen species metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Mukai J et al. (2000) NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR. J Biol Chem 275: 17566-70 PubMed GONUTS page
- ↑ Benzel I et al. (2001) Strain-specific complementation between NRIF1 and NRIF2, two zinc finger proteins sharing structural and biochemical properties. Gene 281: 19-30 PubMed GONUTS page
- ↑ Kuwako K et al. (2005) Disruption of the paternal necdin gene diminishes TrkA signaling for sensory neuron survival. J Neurosci 25: 7090-9 PubMed GONUTS page
- ↑ Malin D et al. (2009) The extracellular-matrix protein matrilin 2 participates in peripheral nerve regeneration. J Cell Sci 122: 995-1004 PubMed GONUTS page
- ↑ Young HM et al. (1999) Expression of Ret-, p75(NTR)-, Phox2a-, Phox2b-, and tyrosine hydroxylase-immunoreactivity by undifferentiated neural crest-derived cells and different classes of enteric neurons in the embryonic mouse gut. Dev Dyn 216: 137-52 PubMed GONUTS page
- ↑ 6.0 6.1 McQuillen PS et al. (2002) A novel role for p75NTR in subplate growth cone complexity and visual thalamocortical innervation. J Neurosci 22: 3580-93 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 7.4 Botchkareva NV et al. (1999) A role for p75 neurotrophin receptor in the control of hair follicle morphogenesis. Dev Biol 216: 135-53 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 Lee KF et al. (1992) Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Cell 69: 737-49 PubMed GONUTS page
- ↑ Sarram S et al. (1997) Dental innervation and CGRP in adult p75-deficient mice. J Comp Neurol 385: 297-308 PubMed GONUTS page
