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MGI:Ngf
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Ngf ( synonyms: Ngfb ) | |
| Protein Name(s) | nerve growth factor, | |
| External Links | ||
| MGI | MGI:97321 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005057 |
receptor signaling protein activity |
MGI:MGI:2450214 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005102 |
receptor binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005163 |
nerve growth factor receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005615 |
extracellular space |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0007422 |
peripheral nervous system development |
MGI:MGI:3027439 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857535 |
P |
From MGI |
||
| GO:0007613 |
memory |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008083 |
growth factor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0339 |
F |
From MGI |
||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008344 |
adult locomotory behavior |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010628 |
positive regulation of gene expression |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0019233 |
sensory perception of pain |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0019233 |
sensory perception of pain |
MGI:MGI:65819 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857535 |
P |
From MGI |
||
| GO:0030307 |
positive regulation of cell growth |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031175 |
neuron projection development |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031954 |
positive regulation of protein autophosphorylation |
MGI:MGI:3835226 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043524 |
negative regulation of neuron apoptotic process |
MGI:MGI:2153439 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99702 |
P |
From MGI |
||
| GO:0045664 |
regulation of neuron differentiation |
MGI:MGI:3621592 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045666 |
positive regulation of neuron differentiation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045773 |
positive regulation of axon extension |
MGI:MGI:80051 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0046928 |
regulation of neurotransmitter secretion |
MGI:MGI:3612345 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97306 |
P |
From MGI |
||
| GO:0051091 |
positive regulation of sequence-specific DNA binding transcription factor activity |
MGI:MGI:3835226 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051388 |
positive regulation of nerve growth factor receptor signaling pathway |
MGI:MGI:3835226 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:2000648 |
positive regulation of stem cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Bouschet T et al. (2003) Stimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, protein kinase C, and protein kinase A in neuronal cells. J Biol Chem 278: 4778-85 PubMed GONUTS page
- ↑ Glebova NO & Ginty DD (2004) Heterogeneous requirement of NGF for sympathetic target innervation in vivo. J Neurosci 24: 743-51 PubMed GONUTS page
- ↑ Crowley C et al. (1994) Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons. Cell 76: 1001-11 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Van Kanegan MJ & Strack S (2009) The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation. Mol Cell Biol 29: 662-74 PubMed GONUTS page
- ↑ Middleton G & Davies AM (2001) Populations of NGF-dependent neurones differ in their requirement for BAX to undergo apoptosis in the absence of NGF/TrkA signalling in vivo. Development 128: 4715-28 PubMed GONUTS page
- ↑ Li HL et al. (2006) The novel neurotrophin-regulated neuronal development-associated protein, NDAP, mediates apoptosis. FEBS Lett 580: 1723-8 PubMed GONUTS page
- ↑ Staecker H et al. (1996) NGF, BDNF and NT-3 play unique roles in the in vitro development and patterning of innervation of the mammalian inner ear. Brain Res Dev Brain Res 92: 49-60 PubMed GONUTS page
- ↑ Hingtgen CM et al. (2006) Stimulus-evoked release of neuropeptides is enhanced in sensory neurons from mice with a heterozygous mutation of the Nf1 gene. Neuroscience 137: 637-45 PubMed GONUTS page
