GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MGI:Nfkbia
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Nfkbia ( synonyms: I(Kappa)B(alpha), I-kappaBalpha, IkappaBalpha, Nfkbi ) | |
| Protein Name(s) | nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha, | |
| External Links | ||
| MGI | MGI:104741 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000060 |
protein import into nucleus, translocation |
MGI:MGI:2176657 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2176150 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3688344 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3694287 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:5284781 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2176657 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:2176657 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:5291872 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:2176657 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0007253 |
cytoplasmic sequestering of NF-kappaB |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007253 |
cytoplasmic sequestering of NF-kappaB |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008139 |
nuclear localization sequence binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0010745 |
negative regulation of macrophage derived foam cell differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010875 |
positive regulation of cholesterol efflux |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010888 |
negative regulation of lipid storage |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0019899 |
enzyme binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0031072 |
heat shock protein binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0031625 |
ubiquitin protein ligase binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0031663 |
lipopolysaccharide-mediated signaling pathway |
MGI:MGI:2670551 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0031663 |
lipopolysaccharide-mediated signaling pathway |
MGI:MGI:3775161 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0032088 |
negative regulation of NF-kappaB transcription factor activity |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032270 |
positive regulation of cellular protein metabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032403 |
protein complex binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0032495 |
response to muramyl dipeptide |
MGI:MGI:3528786 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0032496 |
response to lipopolysaccharide |
MGI:MGI:2670551 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0034142 |
toll-like receptor 4 signaling pathway |
MGI:MGI:3775161 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042127 |
regulation of cell proliferation |
MGI:MGI:2176657 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042802 |
identical protein binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042994 |
cytoplasmic sequestering of transcription factor |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043234 |
protein complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043330 |
response to exogenous dsRNA |
MGI:MGI:2670551 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045638 |
negative regulation of myeloid cell differentiation |
MGI:MGI:3576806 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3577709 |
P |
From MGI |
||
| GO:0045746 |
negative regulation of Notch signaling pathway |
MGI:MGI:3576806 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3577709 |
P |
From MGI |
||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:3805145 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051059 |
NF-kappaB binding |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0051059 |
NF-kappaB binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0070427 |
nucleotide-binding oligomerization domain containing 1 signaling pathway |
MGI:MGI:3775161 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0070431 |
nucleotide-binding oligomerization domain containing 2 signaling pathway |
MGI:MGI:3775161 |
IDA: Inferred from Direct Assay |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Chang NS (2002) The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression. J Biol Chem 277: 10323-31 PubMed GONUTS page
- ↑ Bhatia N et al. (2002) Mouse homologue of HOS (mHOS) is overexpressed in skin tumors and implicated in constitutive activation of NF-kappaB. Oncogene 21: 1501-9 PubMed GONUTS page
- ↑ Papin J & Subramaniam S (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol 15: 78-81 PubMed GONUTS page
- ↑ Gao Z et al. (2006) Regulation of nuclear translocation of HDAC3 by IkappaBalpha is required for tumor necrosis factor inhibition of peroxisome proliferator-activated receptor gamma function. J Biol Chem 281: 4540-7 PubMed GONUTS page
- ↑ Basak S et al. (2007) A fourth IkappaB protein within the NF-kappaB signaling module. Cell 128: 369-81 PubMed GONUTS page
- ↑ Chang M et al. (2011) The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity. Nat Immunol 12: 1002-9 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Hoebe K et al. (2003) Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 424: 743-8 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 Kim YG et al. (2008) The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity 28: 246-57 PubMed GONUTS page
- ↑ Kobayashi KS et al. (2005) Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307: 731-4 PubMed GONUTS page
- ↑ 10.0 10.1 Rupec RA et al. (2005) Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha. Immunity 22: 479-91 PubMed GONUTS page
- ↑ Mitola S et al. (2008) Angiopoietin-1 mediates the proangiogenic activity of the bone morphogenic protein antagonist Drm. Blood 112: 1154-7 PubMed GONUTS page
