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MGI:Nfatc4
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Nfatc4 | |
| Protein Name(s) | nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4, | |
| External Links | ||
| MGI | MGI:1920431 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000981 |
sequence-specific DNA binding RNA polymerase II transcription factor activity |
MGI:MGI:3709926 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0001569 |
patterning of blood vessels |
MGI:MGI:2136698 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103296 |
P |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:2663567 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:3709926 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:2663567 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001100734 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:4819323 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2136698 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3654786 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3709926 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3778102 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001100734 |
C |
From MGI |
||
| GO:0005667 |
transcription factor complex |
MGI:MGI:4819323 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001100734 |
C |
From MGI |
||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:3654786 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:3709926 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:3778102 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001100734 |
C |
From MGI |
||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:2663567 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001100734 |
P |
From MGI |
||
| GO:0007507 |
heart development |
MGI:MGI:2665260 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103296 |
P |
From MGI |
||
| GO:0007507 |
heart development |
MGI:MGI:3712617 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103296 |
P |
From MGI |
||
| GO:0008134 |
transcription factor binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001100734 |
F |
From MGI |
||
| GO:0030154 |
cell differentiation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0221 |
P |
From MGI |
||
| GO:0034644 |
cellular response to UV |
MGI:MGI:3709926 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97583 |
P |
From MGI |
||
| GO:0042975 |
peroxisome proliferator activated receptor binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001100734 |
F |
From MGI |
||
| GO:0043065 |
positive regulation of apoptotic process |
MGI:MGI:3709926 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104798 |
P |
From MGI |
||
| GO:0043065 |
positive regulation of apoptotic process |
MGI:MGI:3778102 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0043065 |
positive regulation of apoptotic process |
MGI:MGI:4829576 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045111 |
intermediate filament cytoskeleton |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045333 |
cellular respiration |
MGI:MGI:2665260 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3654786 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3654786 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3709926 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3716232 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3778102 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4819323 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048167 |
regulation of synaptic plasticity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001100734 |
P |
From MGI |
||
| GO:0051145 |
smooth muscle cell differentiation |
MGI:MGI:2136698 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103296 |
P |
From MGI |
||
| GO:0055001 |
muscle cell development |
MGI:MGI:2136698 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103296 |
P |
From MGI |
||
| GO:0071285 |
cellular response to lithium ion |
MGI:MGI:4829576 |
IDA: Inferred from Direct Assay |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Song L et al. (2007) p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation. Mol Cell Biol 27: 2713-31 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Graef IA et al. (2001) Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell 105: 863-75 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Schubert W et al. (2003) Requirement of transcription factor NFAT in developing atrial myocardium. J Cell Biol 161: 861-74 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Kim HB et al. (2010) Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors. Mol Cell Biol 30: 3126-39 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Yan Y et al. (2006) NFAT3 is specifically required for TNF-alpha-induced cyclooxygenase-2 (COX-2) expression and transformation of Cl41 cells. J Cell Sci 119: 2985-94 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Luoma JI & Zirpel L (2008) Deafferentation-induced activation of NFAT (nuclear factor of activated T-cells) in cochlear nucleus neurons during a developmental critical period: a role for NFATc4-dependent apoptosis in the CNS. J Neurosci 28: 3159-69 PubMed GONUTS page
- ↑ 7.0 7.1 Bushdid PB et al. (2003) NFATc3 and NFATc4 are required for cardiac development and mitochondrial function. Circ Res 92: 1305-13 PubMed GONUTS page
- ↑ Alfieri CM et al. (2007) Developmental regulation of the mouse IGF-I exon 1 promoter region by calcineurin activation of NFAT in skeletal muscle. Am J Physiol Cell Physiol 292: C1887-94 PubMed GONUTS page
- ↑ 9.0 9.1 Gómez-Sintes R & Lucas JJ (2010) NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy. J Clin Invest 120: 2432-45 PubMed GONUTS page
- ↑ Léjard V et al. (2007) Scleraxis and NFATc regulate the expression of the pro-alpha1(I) collagen gene in tendon fibroblasts. J Biol Chem 282: 17665-75 PubMed GONUTS page
