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MGI:Nfatc2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Nfatc2 ( synonyms: NFAT1, NFAT1-D, NFATp ) | |
| Protein Name(s) | nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2, | |
| External Links | ||
| MGI | MGI:102463 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001816 |
cytokine production |
MGI:MGI:3575325 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:2182551 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:2684708 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:3511697 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:3511697 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1326822 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4411947 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3511697 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4411947 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001101275 |
C |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:2182491 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3511697 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:5085959 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001101275 |
C |
From MGI |
||
| GO:0005829 |
cytosol |
MGI:MGI:84562 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:2182551 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2182740 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:3511697 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006974 |
response to DNA damage stimulus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010628 |
positive regulation of gene expression |
MGI:MGI:4411947 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0015629 |
actin cytoskeleton |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030529 |
ribonucleoprotein complex |
MGI:MGI:5085959 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030890 |
positive regulation of B cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042493 |
response to drug |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:84582 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0044212 |
transcription regulatory region DNA binding |
MGI:MGI:4411947 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:3575325 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:2684708 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3511697 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0050853 |
B cell receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Bettelli E et al. (2005) Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells. Proc Natl Acad Sci U S A 102: 5138-43 PubMed GONUTS page
- ↑ 2.0 2.1 Rengarajan J et al. (2000) Sequential involvement of NFAT and Egr transcription factors in FasL regulation. Immunity 12: 293-300 PubMed GONUTS page
- ↑ 3.0 3.1 Plyte S et al. (2001) Identification and characterization of a novel nuclear factor of activated T-cells-1 isoform expressed in mouse brain. J Biol Chem 276: 14350-8 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Asai M et al. (2004) Nuclear factor of activated T cells (NFAT) is involved in the depolarization-induced activation of growth hormone-releasing hormone gene transcription in vitro. Mol Endocrinol 18: 3011-9 PubMed GONUTS page
- ↑ Hodge MR et al. (1996) NF-AT-Driven interleukin-4 transcription potentiated by NIP45. Science 274: 1903-5 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Maitra U et al. (2009) An innate immunity signaling process suppresses macrophage ABCA1 expression through IRAK-1-mediated downregulation of retinoic acid receptor alpha and NFATc2. Mol Cell Biol 29: 5989-97 PubMed GONUTS page
- ↑ Bueno OF et al. (2002) Defective T cell development and function in calcineurin A beta -deficient mice. Proc Natl Acad Sci U S A 99: 9398-403 PubMed GONUTS page
- ↑ 8.0 8.1 Sharma S et al. (2011) Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex. Proc Natl Acad Sci U S A 108: 11381-6 PubMed GONUTS page
- ↑ Luo C et al. (1996) Normal function of the transcription factor NFAT1 in wasted mice. Chromosome localization of NFAT1 gene. Gene 180: 29-36 PubMed GONUTS page
- ↑ Garrett-Sinha LA et al. (1996) A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells. J Biol Chem 271: 31384-90 PubMed GONUTS page
