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MGI:Nf2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Nf2 ( synonyms: merlin, moesin-ezrin-radixin-like protein, schwannomin ) | |
| Protein Name(s) | neurofibromatosis 2, | |
| External Links | ||
| MGI | MGI:97307 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001707 |
mesoderm formation |
MGI:MGI:707944 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857941 |
P |
From MGI |
||
| GO:0001726 |
ruffle |
MGI:MGI:1202233 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005178 |
integrin binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2656687 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2679135 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3613261 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005625 |
soluble fraction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005626 |
insoluble fraction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3047165 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005730 |
nucleolus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3047165 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:79149 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005769 |
early endosome |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005856 |
cytoskeleton |
MGI:MGI:3513729 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005912 |
adherens junction |
MGI:MGI:2656687 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857941 |
C |
From MGI |
||
| GO:0006469 |
negative regulation of protein kinase activity |
MGI:MGI:2679135 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006469 |
negative regulation of protein kinase activity |
MGI:MGI:3613261 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0007398 |
ectoderm development |
MGI:MGI:707944 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857941 |
P |
From MGI |
||
| GO:0008013 |
beta-catenin binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008092 |
cytoskeletal protein binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR011174 |
F |
From MGI |
||
| GO:0008156 |
negative regulation of DNA replication |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:1203257 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857941 |
P |
From MGI |
||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:1860693 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926957 |
P |
From MGI |
||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0014010 |
Schwann cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0019898 |
extrinsic to membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR011174 |
C |
From MGI |
||
| GO:0019904 |
protein domain specific binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0022408 |
negative regulation of cell-cell adhesion |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030027 |
lamellipodium |
MGI:MGI:1202233 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030036 |
actin cytoskeleton organization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030175 |
filopodium |
MGI:MGI:1202233 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030308 |
negative regulation of cell growth |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030864 |
cortical actin cytoskeleton |
MGI:MGI:3513729 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0032154 |
cleavage furrow |
MGI:MGI:1197341 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0035330 |
regulation of hippo signaling cascade |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042127 |
regulation of cell proliferation |
MGI:MGI:2656687 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857941 |
P |
From MGI |
||
| GO:0042475 |
odontogenesis of dentin-containing tooth |
MGI:MGI:1860693 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926957 |
P |
From MGI |
||
| GO:0042518 |
negative regulation of tyrosine phosphorylation of Stat3 protein |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042524 |
negative regulation of tyrosine phosphorylation of Stat5 protein |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042995 |
cell projection |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0966 |
C |
From MGI |
||
| GO:0043234 |
protein complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043409 |
negative regulation of MAPK cascade |
MGI:MGI:3613261 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045121 |
membrane raft |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045202 |
synapse |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045216 |
cell-cell junction organization |
MGI:MGI:2656687 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857941 |
P |
From MGI |
||
| GO:0046426 |
negative regulation of JAK-STAT cascade |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048471 |
perinuclear region of cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0048471 |
perinuclear region of cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0051496 |
positive regulation of stress fiber assembly |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070306 |
lens fiber cell differentiation |
MGI:MGI:4457460 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 McClatchey AI et al. (1997) The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation. Genes Dev 11: 1253-65 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Shaw RJ et al. (1998) Localization and functional domains of the neurofibromatosis type II tumor suppressor, merlin. Cell Growth Differ 9: 287-96 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Lallemand D et al. (2003) NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions. Genes Dev 17: 1090-100 PubMed GONUTS page
- ↑ 4.0 4.1 Kissil JL et al. (2003) Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1. Mol Cell 12: 841-9 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Lim JY et al. (2006) Merlin inhibits growth hormone-regulated Raf-ERKs pathways by binding to Grb2 protein. Biochem Biophys Res Commun 340: 1151-7 PubMed GONUTS page
- ↑ 6.0 6.1 Shollar D et al. (2004) JCV T-antigen interacts with the neurofibromatosis type 2 gene product in a transgenic mouse model of malignant peripheral nerve sheath tumors. Oncogene 23: 5459-67 PubMed GONUTS page
- ↑ Claudio JO et al. (1995) Widespread but cell type-specific expression of the mouse neurofibromatosis type 2 gene. Neuroreport 6: 1942-6 PubMed GONUTS page
- ↑ 8.0 8.1 Wiederhold T et al. (2004) Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2. Oncogene 23: 8815-25 PubMed GONUTS page
- ↑ McClatchey AI et al. (1998) Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors. Genes Dev 12: 1121-33 PubMed GONUTS page
- ↑ 10.0 10.1 Giovannini M et al. (2000) Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2. Genes Dev 14: 1617-30 PubMed GONUTS page
- ↑ Lendahl U (1998) A growing family of Notch ligands. Bioessays 20: 103-7 PubMed GONUTS page
- ↑ Wiley LA et al. (2010) The tumor suppressor merlin is required for cell cycle exit, terminal differentiation, and cell polarity in the developing murine lens. Invest Ophthalmol Vis Sci 51: 3611-8 PubMed GONUTS page
