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MGI:Neurog3
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Neurog3 ( synonyms: Atoh5, bHLHa7, Math4B, ngn3 ) | |
| Protein Name(s) | neurogenin 3, | |
| External Links | ||
| MGI | MGI:893591 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001077 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0238 |
F |
From MGI |
||
| GO:0003690 |
double-stranded DNA binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:3619850 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003713 |
transcription coactivator activity |
MGI:MGI:4420345 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2670558 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:2181532 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2651394 |
P |
From MGI |
||
| GO:0007399 |
nervous system development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0524 |
P |
From MGI |
||
| GO:0030154 |
cell differentiation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0221 |
P |
From MGI |
||
| GO:0030855 |
epithelial cell differentiation |
MGI:MGI:2181532 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2651394 |
P |
From MGI |
||
| GO:0044424 |
intracellular part |
MGI:MGI:3614320 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0044424 |
intracellular part |
MGI:MGI:3706893 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0045666 |
positive regulation of neuron differentiation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3619850 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051091 |
positive regulation of sequence-specific DNA binding transcription factor activity |
MGI:MGI:4420345 |
IDA: Inferred from Direct Assay |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Mellitzer G et al. (2006) IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas. EMBO J 25: 1344-52 PubMed GONUTS page
- ↑ 2.0 2.1 Anderson KR et al. (2009) Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. J Biol Chem 284: 31236-48 PubMed GONUTS page
- ↑ Hald J et al. (2003) Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. Dev Biol 260: 426-37 PubMed GONUTS page
- ↑ 4.0 4.1 Lee CS et al. (2002) Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity. Genes Dev 16: 1488-97 PubMed GONUTS page
- ↑ Chu K & Tsai MJ (2005) Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion. Diabetes 54: 1064-73 PubMed GONUTS page
- ↑ Jensen J et al. (2000) Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation. Diabetes 49: 163-76 PubMed GONUTS page
