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MGI:Nes

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Nes ( synonyms: ESTM46 )
Protein Name(s) nestin,
External Links
MGI MGI:101784

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000086

G2/M transition of mitotic cell cycle

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P48681

P

From MGI

GO:0005198

structural molecule activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR001664

F

From MGI

GO:0005622

intracellular

MGI:MGI:2156920
PMID:11744388[1]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005622

intracellular

MGI:MGI:3664674
PMID:16892058[2]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:2686772
PMID:14706696[3]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:3770606
PMID:17901127[4]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:3810896
PMID:18614158[5]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:3821634
PMID:19036983[6]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:3848848
PMID:19409199[7]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P48681

C

From MGI

GO:0005882

intermediate filament

MGI:MGI:1099676
PMID:9364068[8]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005882

intermediate filament

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:O09019

C

From MGI

GO:0007275

multicellular organismal development

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

From MGI

GO:0007399

nervous system development

MGI:MGI:2657081
PMID:12687705[9]

IDA: Inferred from Direct Assay

P

From MGI

GO:0030844

positive regulation of intermediate filament depolymerization

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:O09019

P

From MGI

GO:0031730

CCR5 chemokine receptor binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:O09019

F

From MGI

GO:0043066

negative regulation of apoptotic process

MGI:MGI:4889157
PMID:20963821[10]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0045111

intermediate filament cytoskeleton

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P48681

C

From MGI

GO:0048858

cell projection morphogenesis

MGI:MGI:3655785
PMID:16571784[11]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0072089

stem cell proliferation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P48681

P

From MGI

GO:2000179

positive regulation of neural precursor cell proliferation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:O09019

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Sánchez D et al. (2002) Expression pattern of the lipocalin apolipoprotein D during mouse embryogenesis. Mech Dev 110: 225-9 PubMed GONUTS page
  2. Cappello S et al. (2006) The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface. Nat Neurosci 9: 1099-107 PubMed GONUTS page
  3. Esni F et al. (2004) Origin of exocrine pancreatic cells from nestin-positive precursors in developing mouse pancreas. Mech Dev 121: 15-25 PubMed GONUTS page
  4. Li W et al. (2008) Nuclear receptor TLX regulates cell cycle progression in neural stem cells of the developing brain. Mol Endocrinol 22: 56-64 PubMed GONUTS page
  5. Ding X et al. (2008) Localization and cellular distribution of CPNE5 in embryonic mouse brain. Brain Res 1224: 20-8 PubMed GONUTS page
  6. Willaredt MA et al. (2008) A crucial role for primary cilia in cortical morphogenesis. J Neurosci 28: 12887-900 PubMed GONUTS page
  7. Bai Y et al. (2009) An Ang1-Tie2-PI3K axis in neural progenitor cells initiates survival responses against oxygen and glucose deprivation. Neuroscience 160: 371-81 PubMed GONUTS page
  8. Shibata T et al. (1997) Glutamate transporter GLAST is expressed in the radial glia-astrocyte lineage of developing mouse spinal cord. J Neurosci 17: 9212-9 PubMed GONUTS page
  9. Liu Z & Martin LJ (2003) Olfactory bulb core is a rich source of neural progenitor and stem cells in adult rodent and human. J Comp Neurol 459: 368-91 PubMed GONUTS page
  10. Park D et al. (2010) Nestin is required for the proper self-renewal of neural stem cells. Stem Cells 28: 2162-71 PubMed GONUTS page
  11. Chen J et al. (2006) Differential expression of the intermediate filament protein nestin during renal development and its localization in adult podocytes. J Am Soc Nephrol 17: 1283-91 PubMed GONUTS page
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