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MGI:Nedd4
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Nedd4 ( synonyms: Nedd4, Nedd4-1, Nedd4a ) | |
| Protein Name(s) | neural precursor cell expressed, developmentally down-regulated 4, | |
| External Links | ||
| MGI | MGI:97297 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000151 |
ubiquitin ligase complex |
MGI:MGI:1927025 |
IPI: Inferred from Physical Interaction |
C |
From MGI |
|||
| GO:0000785 |
chromatin |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0004842 |
ubiquitin-protein ligase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004842 |
ubiquitin-protein ligase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004842 |
ubiquitin-protein ligase activity |
MGI:MGI:892833 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1342855 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3713955 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3713955 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4441129 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4835109 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:3038342 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3038342 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:892833 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005902 |
microvillus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005938 |
cell cortex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006464 |
protein modification process |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0006622 |
protein targeting to lysosome |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007041 |
lysosomal transport |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007399 |
nervous system development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0524 |
P |
From MGI |
||
| GO:0008022 |
protein C-terminus binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0010766 |
negative regulation of sodium ion transport |
MGI:MGI:1336453 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0010766 |
negative regulation of sodium ion transport |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010768 |
negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0014068 |
positive regulation of phosphatidylinositol 3-kinase cascade |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016567 |
protein ubiquitination |
MGI:MGI:892833 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0016874 |
ligase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0436 |
F |
From MGI |
||
| GO:0016881 |
acid-amino acid ligase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0019089 |
transmission of virus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0019871 |
sodium channel inhibitor activity |
MGI:MGI:1336453 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0019871 |
sodium channel inhibitor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019904 |
protein domain specific binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030948 |
negative regulation of vascular endothelial growth factor receptor signaling pathway |
MGI:MGI:4441129 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0031623 |
receptor internalization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031698 |
beta-2 adrenergic receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0032801 |
receptor catabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0034644 |
cellular response to UV |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042787 |
protein ubiquitination involved in ubiquitin-dependent protein catabolic process |
MGI:MGI:4459044 |
PANTHER:PTHR11254 |
P |
From MGI |
|||
| GO:0042787 |
protein ubiquitination involved in ubiquitin-dependent protein catabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042921 |
glucocorticoid receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043130 |
ubiquitin binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043162 |
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0044111 |
development involved in symbiotic interaction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045121 |
membrane raft |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045732 |
positive regulation of protein catabolic process |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045732 |
positive regulation of protein catabolic process |
MGI:MGI:2176314 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046824 |
positive regulation of nucleocytoplasmic transport |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048471 |
perinuclear region of cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0048814 |
regulation of dendrite morphogenesis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048814 |
regulation of dendrite morphogenesis |
MGI:MGI:4835109 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0050815 |
phosphoserine binding |
MGI:MGI:3813439 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0050816 |
phosphothreonine binding |
MGI:MGI:3813439 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0050847 |
progesterone receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070063 |
RNA polymerase binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0070064 |
proline-rich region binding |
MGI:MGI:2176314 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0070064 |
proline-rich region binding |
MGI:MGI:3814925 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0070064 |
proline-rich region binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0070534 |
protein K63-linked ubiquitination |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Jolliffe CN et al. (2000) Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4. Biochem J 351 Pt 3: 557-65 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Hatakeyama S et al. (1997) Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases. J Biol Chem 272: 15085-92 PubMed GONUTS page
- ↑ Morrione A et al. (1999) mGrb10 interacts with Nedd4. J Biol Chem 274: 24094-9 PubMed GONUTS page
- ↑ 4.0 4.1 Sanchez-Perez A et al. (2007) GRK2 interacts with and phosphorylates Nedd4 and Nedd4-2. Biochem Biophys Res Commun 359: 611-5 PubMed GONUTS page
- ↑ 5.0 5.1 Murdaca J et al. (2004) Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation. J Biol Chem 279: 26754-61 PubMed GONUTS page
- ↑ 6.0 6.1 Kawabe H et al. (2010) Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development. Neuron 65: 358-72 PubMed GONUTS page
- ↑ 7.0 7.1 Heissmeyer V et al. (2004) Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat Immunol 5: 255-65 PubMed GONUTS page
- ↑ 8.0 8.1 Harvey KF et al. (1999) All three WW domains of murine Nedd4 are involved in the regulation of epithelial sodium channels by intracellular Na+. J Biol Chem 274: 12525-30 PubMed GONUTS page
- ↑ 9.0 9.1 Harvey KF et al. (2002) N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein. J Biol Chem 277: 9307-17 PubMed GONUTS page
- ↑ 10.0 10.1 Lu PJ et al. (1999) Function of WW domains as phosphoserine- or phosphothreonine-binding modules. Science 283: 1325-8 PubMed GONUTS page
- ↑ Gavva NR et al. (1997) Interaction of WW domains with hematopoietic transcription factor p45/NF-E2 and RNA polymerase II. J Biol Chem 272: 24105-8 PubMed GONUTS page
