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MGI:Ndel1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Ndel1 ( synonyms: mNudel ) | |
| Protein Name(s) | nuclear distribution gene E-like homolog 1 (A. nidulans), | |
| External Links | ||
| MGI | MGI:1932915 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000226 |
microtubule cytoskeleton organization |
MGI:MGI:3588829 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:109520 |
P |
From MGI |
||
| GO:0000775 |
chromosome, centromeric region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0137 |
C |
From MGI |
||
| GO:0000776 |
kinetochore |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0001764 |
neuron migration |
MGI:MGI:3588829 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:109520 |
P |
From MGI |
||
| GO:0001833 |
inner cell mass cell proliferation |
MGI:MGI:3588829 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3589467 |
P |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:1932152 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3778569 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4821185 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:3588829 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1914453 |
C |
From MGI |
||
| GO:0005635 |
nuclear envelope |
MGI:MGI:3822230 |
ISS: Inferred from Sequence or Structural Similarity |
C |
From MGI |
|||
| GO:0005694 |
chromosome |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0158 |
C |
From MGI |
||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_579854 |
C |
From MGI |
||
| GO:0005813 |
centrosome |
MGI:MGI:1928548 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005813 |
centrosome |
MGI:MGI:1928566 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005813 |
centrosome |
MGI:MGI:3608033 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005813 |
centrosome |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_579854 |
C |
From MGI |
||
| GO:0005856 |
cytoskeleton |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0206 |
C |
From MGI |
||
| GO:0005871 |
kinesin complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_579854 |
C |
From MGI |
||
| GO:0005874 |
microtubule |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0493 |
C |
From MGI |
||
| GO:0005875 |
microtubule associated complex |
MGI:MGI:1928566 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006810 |
transport |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0813 |
P |
From MGI |
||
| GO:0007059 |
chromosome segregation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0217 |
P |
From MGI |
||
| GO:0007399 |
nervous system development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0524 |
P |
From MGI |
||
| GO:0008017 |
microtubule binding |
MGI:MGI:1928566 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0008090 |
retrograde axon cargo transport |
MGI:MGI:1928566 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0008152 |
metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_579854 |
P |
From MGI |
||
| GO:0010975 |
regulation of neuron projection development |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_579854 |
P |
From MGI |
||
| GO:0010975 |
regulation of neuron projection development |
MGI:MGI:4441254 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0016477 |
cell migration |
MGI:MGI:3778569 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0021799 |
cerebral cortex radially oriented cell migration |
MGI:MGI:4821185 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0021955 |
central nervous system neuron axonogenesis |
MGI:MGI:3047464 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030154 |
cell differentiation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0221 |
P |
From MGI |
||
| GO:0030424 |
axon |
MGI:MGI:3608033 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030424 |
axon |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_579854 |
C |
From MGI |
||
| GO:0031175 |
neuron projection development |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_579854 |
P |
From MGI |
||
| GO:0031252 |
cell leading edge |
MGI:MGI:3778569 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0032403 |
protein complex binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_579854 |
F |
From MGI |
||
| GO:0032864 |
activation of Cdc42 GTPase activity |
MGI:MGI:3778569 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0043014 |
alpha-tubulin binding |
MGI:MGI:3778569 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0044297 |
cell body |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_579854 |
C |
From MGI |
||
| GO:0045773 |
positive regulation of axon extension |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_579854 |
P |
From MGI |
||
| GO:0047496 |
vesicle transport along microtubule |
MGI:MGI:3588829 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1914453 |
P |
From MGI |
||
| GO:0048487 |
beta-tubulin binding |
MGI:MGI:3778569 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0048680 |
positive regulation of axon regeneration |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_579854 |
P |
From MGI |
||
| GO:0051081 |
nuclear envelope disassembly |
MGI:MGI:3822230 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From MGI |
|||
| GO:0051642 |
centrosome localization |
MGI:MGI:3778569 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060052 |
neurofilament cytoskeleton organization |
MGI:MGI:3047464 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060053 |
neurofilament cytoskeleton |
MGI:MGI:3047464 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0070012 |
oligopeptidase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_579854 |
F |
From MGI |
||
|
NOT |
GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:4821185 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Sasaki S et al. (2005) Complete loss of Ndel1 results in neuronal migration defects and early embryonic lethality. Mol Cell Biol 25: 7812-27 PubMed GONUTS page
- ↑ Sweeney KJ et al. (2001) NudE-L, a novel Lis1-interacting protein, belongs to a family of vertebrate coiled-coil proteins. Mech Dev 101: 21-33 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Shen Y et al. (2008) Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells. Dev Cell 14: 342-53 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Singh KK et al. (2010) Dixdc1 is a critical regulator of DISC1 and embryonic cortical development. Neuron 67: 33-48 PubMed GONUTS page
- ↑ 5.0 5.1 Hebbar S et al. (2008) Lis1 and Ndel1 influence the timing of nuclear envelope breakdown in neural stem cells. J Cell Biol 182: 1063-71 PubMed GONUTS page
- ↑ Niethammer M et al. (2000) NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein. Neuron 28: 697-711 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Sasaki S et al. (2000) A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system. Neuron 28: 681-96 PubMed GONUTS page
- ↑ 8.0 8.1 Toyo-Oka K et al. (2005) Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration. Hum Mol Genet 14: 3113-28 PubMed GONUTS page
- ↑ Duan X et al. (2007) Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. Cell 130: 1146-58 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Nguyen MD et al. (2004) A NUDEL-dependent mechanism of neurofilament assembly regulates the integrity of CNS neurons. Nat Cell Biol 6: 595-608 PubMed GONUTS page
