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MGI:Nbn
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Nbn ( synonyms: Nbs1 ) | |
| Protein Name(s) | nibrin, | |
| External Links | ||
| MGI | MGI:1351625 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000077 |
DNA damage checkpoint |
MGI:MGI:2449744 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0000723 |
telomere maintenance |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0000781 |
chromosome, telomeric region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0779 |
C |
From MGI |
||
| GO:0000784 |
nuclear chromosome, telomeric region |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0001701 |
in utero embryonic development |
MGI:MGI:2680772 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0001832 |
blastocyst growth |
MGI:MGI:2680772 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0003684 |
damaged DNA binding |
MGI:MGI:2179182 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2150845 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005657 |
replication fork |
MGI:MGI:2179182 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005694 |
chromosome |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0158 |
C |
From MGI |
||
| GO:0005730 |
nucleolus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006281 |
DNA repair |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0234 |
P |
From MGI |
||
| GO:0006302 |
double-strand break repair |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006915 |
apoptotic process |
MGI:MGI:3805397 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3027036 |
P |
From MGI |
||
| GO:0006974 |
response to DNA damage stimulus |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0227 |
P |
From MGI |
||
| GO:0007049 |
cell cycle |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0131 |
P |
From MGI |
||
| GO:0007095 |
mitotic cell cycle G2/M transition DNA damage checkpoint |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007126 |
meiosis |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0469 |
P |
From MGI |
||
| GO:0008134 |
transcription factor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008283 |
cell proliferation |
MGI:MGI:3577830 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3578646 |
P |
From MGI |
||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_620228 |
P |
From MGI |
||
| GO:0030870 |
Mre11 complex |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0031575 |
mitotic cell cycle G1/S transition checkpoint |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031576 |
G2/M transition checkpoint |
MGI:MGI:3805397 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2183796 |
P |
From MGI |
||
| GO:0031954 |
positive regulation of protein autophosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032508 |
DNA duplex unwinding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0033674 |
positive regulation of kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042405 |
nuclear inclusion body |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045190 |
isotype switching |
MGI:MGI:3529405 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045665 |
negative regulation of neuron differentiation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_620228 |
P |
From MGI |
||
| GO:0047485 |
protein N-terminus binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0048145 |
regulation of fibroblast proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_620228 |
P |
From MGI |
||
| GO:0050885 |
neuromuscular process controlling balance |
MGI:MGI:3577830 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3578646 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Weiss RS et al. (2003) Critical role for mouse Hus1 in an S-phase DNA damage cell cycle checkpoint. Mol Cell Biol 23: 791-803 PubMed GONUTS page
- ↑ 2.0 2.1 Dumon-Jones V et al. (2003) Nbn heterozygosity renders mice susceptible to tumor formation and ionizing radiation-induced tumorigenesis. Cancer Res 63: 7263-9 PubMed GONUTS page
- ↑ 3.0 3.1 Celeste A et al. (2002) Genomic instability in mice lacking histone H2AX. Science 296: 922-7 PubMed GONUTS page
- ↑ Sutherland HG et al. (2001) Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Hum Mol Genet 10: 1995-2011 PubMed GONUTS page
- ↑ 5.0 5.1 Stracker TH et al. (2008) Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage. Mol Cell 31: 21-32 PubMed GONUTS page
- ↑ 6.0 6.1 Frappart PO et al. (2005) An essential function for NBS1 in the prevention of ataxia and cerebellar defects. Nat Med 11: 538-44 PubMed GONUTS page
- ↑ Kracker S et al. (2005) Nibrin functions in Ig class-switch recombination. Proc Natl Acad Sci U S A 102: 1584-9 PubMed GONUTS page
