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MGI:Nanog
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Nanog ( synonyms: ecat4, ENK ) | |
| Protein Name(s) | Nanog homeobox, | |
| External Links | ||
| MGI | MGI:1919200 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3654744 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103302 |
P |
From MGI |
||
| GO:0001158 |
enhancer sequence-specific DNA binding |
MGI:MGI:4946171 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0001710 |
mesodermal cell fate commitment |
MGI:MGI:3654744 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:109452 |
P |
From MGI |
||
| GO:0001714 |
endodermal cell fate specification |
MGI:MGI:4887279 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:2661864 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:3621412 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003682 |
chromatin binding |
MGI:MGI:3804326 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4399017 |
IPI: Inferred from Physical Interaction |
UniProtKB:P20263 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:4946164 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4946171 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005625 |
soluble fraction |
MGI:MGI:4367296 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3527362 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3578587 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3608143 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3799386 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4367296 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001094251 |
C |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:4422111 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4889168 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4946462 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005654 |
nucleoplasm |
MGI:MGI:4946164 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005730 |
nucleolus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0217 |
P |
From MGI |
||
| GO:0008283 |
cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:3608143 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0009790 |
embryo development |
MGI:MGI:2661864 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2664492 |
P |
From MGI |
||
| GO:0010454 |
negative regulation of cell fate commitment |
MGI:MGI:3654744 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0010454 |
negative regulation of cell fate commitment |
MGI:MGI:3654744 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:109452 |
P |
From MGI |
||
| GO:0010468 |
regulation of gene expression |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0017145 |
stem cell division |
MGI:MGI:2663314 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0019827 |
stem cell maintenance |
MGI:MGI:2661864 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2664492 |
P |
From MGI |
||
| GO:0019827 |
stem cell maintenance |
MGI:MGI:3654397 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0019827 |
stem cell maintenance |
MGI:MGI:3654744 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030514 |
negative regulation of BMP signaling pathway |
MGI:MGI:3654744 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0032526 |
response to retinoic acid |
MGI:MGI:3795829 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0035019 |
somatic stem cell maintenance |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042221 |
response to chemical stimulus |
MGI:MGI:3795829 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042664 |
negative regulation of endodermal cell fate specification |
MGI:MGI:3690198 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:3795829 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:4889168 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0044212 |
transcription regulatory region DNA binding |
MGI:MGI:4422111 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0045595 |
regulation of cell differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045596 |
negative regulation of cell differentiation |
MGI:MGI:3764939 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045596 |
negative regulation of cell differentiation |
MGI:MGI:3764939 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:4889168 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045931 |
positive regulation of mitotic cell cycle |
MGI:MGI:3608143 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4887279 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4889168 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0048863 |
stem cell differentiation |
MGI:MGI:3689688 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0048863 |
stem cell differentiation |
MGI:MGI:4422111 |
IDA: Inferred from Direct Assay |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Suzuki A et al. (2006) Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Proc Natl Acad Sci U S A 103: 10294-9 PubMed GONUTS page
- ↑ 2.0 2.1 Karantzali E et al. (2011) Sall1 regulates embryonic stem cell differentiation in association with nanog. J Biol Chem 286: 1037-45 PubMed GONUTS page
- ↑ 3.0 3.1 Teo AK et al. (2011) Pluripotency factors regulate definitive endoderm specification through eomesodermin. Genes Dev 25: 238-50 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Mitsui K et al. (2003) The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 113: 631-42 PubMed GONUTS page
- ↑ Loh YH et al. (2006) The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet 38: 431-40 PubMed GONUTS page
- ↑ Tam WL et al. (2008) T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways. Stem Cells 26: 2019-31 PubMed GONUTS page
- ↑ Wang J et al. (2006) A protein interaction network for pluripotency of embryonic stem cells. Nature 444: 364-8 PubMed GONUTS page
- ↑ 8.0 8.1 Johansson H & Simonsson S (2010) Core transcription factors, Oct4, Sox2 and Nanog, individually form complexes with nucleophosmin (Npm1) to control embryonic stem (ES) cell fate determination. Aging (Albany NY) 2: 815-22 PubMed GONUTS page
- ↑ 9.0 9.1 Nishiyama A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5: 420-33 PubMed GONUTS page
- ↑ Hatano SY et al. (2005) Pluripotential competence of cells associated with Nanog activity. Mech Dev 122: 67-79 PubMed GONUTS page
- ↑ Strumpf D et al. (2005) Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst. Development 132: 2093-102 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 Zhang J et al. (2005) Expression of Nanog gene promotes NIH3T3 cell proliferation. Biochem Biophys Res Commun 338: 1098-102 PubMed GONUTS page
- ↑ Strizzi L et al. (2008) Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland. J Cell Physiol 216: 824-34 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 Niakan KK et al. (2010) Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev 24: 312-26 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 15.3 Kelly VR & Hammer GD (2011) LRH-1 and Nanog regulate Dax1 transcription in mouse embryonic stem cells. Mol Cell Endocrinol 332: 116-24 PubMed GONUTS page
- ↑ Artus J et al. (2011) The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17. Dev Biol 350: 393-404 PubMed GONUTS page
- ↑ Chambers I et al. (2003) Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 113: 643-55 PubMed GONUTS page
- ↑ Ivanova N et al. (2006) Dissecting self-renewal in stem cells with RNA interference. Nature 442: 533-8 PubMed GONUTS page
- ↑ 19.0 19.1 19.2 Kunarso G et al. (2008) Detailed characterization of the mouse embryonic stem cell transcriptome reveals novel genes and intergenic splicing associated with pluripotency. BMC Genomics 9: 155 PubMed GONUTS page
- ↑ Darr H et al. (2006) Overexpression of NANOG in human ES cells enables feeder-free growth while inducing primitive ectoderm features. Development 133: 1193-201 PubMed GONUTS page
- ↑ 21.0 21.1 Shimoda M et al. (2007) Sox17 plays a substantial role in late-stage differentiation of the extraembryonic endoderm in vitro. J Cell Sci 120: 3859-69 PubMed GONUTS page
- ↑ Pereira L et al. (2006) Repression of Nanog gene transcription by Tcf3 limits embryonic stem cell self-renewal. Mol Cell Biol 26: 7479-91 PubMed GONUTS page
