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MGI:Myod1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Myod1 ( synonyms: bHLHc1, MYF3, MyoD, Myod-1 ) | |
| Protein Name(s) | myogenic differentiation 1, | |
| External Links | ||
| MGI | MGI:97275 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000381 |
regulation of alternative nuclear mRNA splicing, via spliceosome |
MGI:MGI:1202143 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0000381 |
regulation of alternative nuclear mRNA splicing, via spliceosome |
MGI:MGI:1202143 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0000790 |
nuclear chromatin |
MGI:MGI:4838688 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:2651740 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:2651740 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003705 |
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity |
MGI:MGI:75196 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2153314 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4360820 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4838954 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:5315343 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:86048 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2153314 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2668811 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3840749 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4367296 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:5306562 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:75196 |
TAS: Traceable Author Statement |
C |
From MGI |
|||
| GO:0005667 |
transcription factor complex |
MGI:MGI:1261954 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3840749 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0805 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4367296 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
MGI:MGI:75196 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0217 |
P |
From MGI |
||
| GO:0007517 |
muscle organ development |
MGI:MGI:3047475 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007517 |
muscle organ development |
MGI:MGI:3525903 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97252 |
P |
From MGI |
||
| GO:0007518 |
myoblast cell fate determination |
MGI:MGI:2651740 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007519 |
skeletal muscle tissue development |
MGI:MGI:2180395 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007519 |
skeletal muscle tissue development |
MGI:MGI:3027696 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007519 |
skeletal muscle tissue development |
MGI:MGI:3586427 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:94909 |
P |
From MGI |
||
| GO:0007519 |
skeletal muscle tissue development |
MGI:MGI:3849775 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857221 |
P |
From MGI |
||
| GO:0007519 |
skeletal muscle tissue development |
MGI:MGI:64468 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97252 |
P |
From MGI |
||
| GO:0007519 |
skeletal muscle tissue development |
MGI:MGI:75196 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0008134 |
transcription factor binding |
MGI:MGI:1261954 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0009267 |
cellular response to starvation |
MGI:MGI:3840749 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0014908 |
myotube differentiation involved in skeletal muscle regeneration |
MGI:MGI:48687 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0019899 |
enzyme binding |
MGI:MGI:4838688 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0030016 |
myofibril |
MGI:MGI:3840749 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030154 |
cell differentiation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0221 |
P |
From MGI |
||
| GO:0031625 |
ubiquitin protein ligase binding |
MGI:MGI:3840749 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0043415 |
positive regulation of skeletal muscle tissue regeneration |
MGI:MGI:3692808 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0043503 |
skeletal muscle fiber adaptation |
MGI:MGI:3840749 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045445 |
myoblast differentiation |
MGI:MGI:2180395 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045445 |
myoblast differentiation |
MGI:MGI:2651740 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:2670853 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:3521604 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:3763850 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:2651740 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3522534 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1926387 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3767901 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3849299 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:75914 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046982 |
protein heterodimerization activity |
MGI:MGI:3522534 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0048741 |
skeletal muscle fiber development |
MGI:MGI:3840749 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0051146 |
striated muscle cell differentiation |
MGI:MGI:3692808 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0071385 |
cellular response to glucocorticoid stimulus |
MGI:MGI:3840749 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0071453 |
cellular response to oxygen levels |
MGI:MGI:3840749 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
|
contributes_to |
GO:0003677 |
DNA binding |
MGI:MGI:1261954 |
IDA: Inferred from Direct Assay |
F |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Ichida M et al. (1998) MyoD is indispensable for muscle-specific alternative splicing in mouse mitochondrial ATP synthase gamma-subunit pre-mRNA. J Biol Chem 273: 8492-501 PubMed GONUTS page
- ↑ 2.0 2.1 Choi J et al. (2010) Histone demethylase LSD1 is required to induce skeletal muscle differentiation by regulating myogenic factors. Biochem Biophys Res Commun 401: 327-32 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Meech R et al. (2003) The homeodomain protein Barx2 promotes myogenic differentiation and is regulated by myogenic regulatory factors. J Biol Chem 278: 8269-78 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Weintraub H et al. (1991) The myoD gene family: nodal point during specification of the muscle cell lineage. Science 251: 761-6 PubMed GONUTS page
- ↑ 5.0 5.1 Liu D et al. (2001) TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3. Genes Dev 15: 2950-66 PubMed GONUTS page
- ↑ Sambasivan R et al. (2009) The small chromatin-binding protein p8 coordinates the association of anti-proliferative and pro-myogenic proteins at the myogenin promoter. J Cell Sci 122: 3481-91 PubMed GONUTS page
- ↑ Bruscoli S et al. (2010) Glucocorticoid-induced leucine zipper (GILZ) and long GILZ inhibit myogenic differentiation and mediate anti-myogenic effects of glucocorticoids. J Biol Chem 285: 10385-96 PubMed GONUTS page
- ↑ Caretti G et al. (2006) The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation. Dev Cell 11: 547-60 PubMed GONUTS page
- ↑ Chen B & Lim RW (1997) Physical and functional interactions between the transcriptional inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism regulating muscle-specific gene expression. J Biol Chem 272: 2459-63 PubMed GONUTS page
- ↑ Holst D et al. (2003) Roles of peroxisome proliferator-activated receptors delta and gamma in myoblast transdifferentiation. Exp Cell Res 288: 168-76 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 11.4 11.5 11.6 11.7 11.8 Lagirand-Cantaloube J et al. (2009) Inhibition of atrogin-1/MAFbx mediated MyoD proteolysis prevents skeletal muscle atrophy in vivo. PLoS One 4: e4973 PubMed GONUTS page
- ↑ 12.0 12.1 Nishiyama A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5: 420-33 PubMed GONUTS page
- ↑ Stuelsatz P et al. (2010) Down-regulation of MyoD by calpain 3 promotes generation of reserve cells in C2C12 myoblasts. J Biol Chem 285: 12670-83 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 Murre C et al. (1989) Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell 58: 537-44 PubMed GONUTS page
- ↑ Lee H et al. (2004) MSX1 cooperates with histone H1b for inhibition of transcription and myogenesis. Science 304: 1675-8 PubMed GONUTS page
- ↑ Brent AE et al. (2005) Genetic analysis of interactions between the somitic muscle, cartilage and tendon cell lineages during mouse development. Development 132: 515-28 PubMed GONUTS page
- ↑ 17.0 17.1 Ge K et al. (2002) Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Nature 417: 563-7 PubMed GONUTS page
- ↑ Günther S et al. (2004) VITO-1 is an essential cofactor of TEF1-dependent muscle-specific gene regulation. Nucleic Acids Res 32: 791-802 PubMed GONUTS page
- ↑ Inanlou MR & Kablar B (2003) Abnormal development of the diaphragm in mdx:MyoD-/-(9th) embryos leads to pulmonary hypoplasia. Int J Dev Biol 47: 363-71 PubMed GONUTS page
- ↑ Sambasivan R et al. (2009) Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates. Dev Cell 16: 810-21 PubMed GONUTS page
- ↑ Rudnicki MA et al. (1993) MyoD or Myf-5 is required for the formation of skeletal muscle. Cell 75: 1351-9 PubMed GONUTS page
- ↑ Dyson PJ et al. (1992) Mapping of the genes encoding tum- transplantation antigens P91A, P35B, and P198. Immunogenetics 35: 316-23 PubMed GONUTS page
- ↑ 23.0 23.1 Duquet A et al. (2006) Acetylation is important for MyoD function in adult mice. EMBO Rep 7: 1140-6 PubMed GONUTS page
- ↑ Schmidt K et al. (2003) Sox8 is a specific marker for muscle satellite cells and inhibits myogenesis. J Biol Chem 278: 29769-75 PubMed GONUTS page
- ↑ Kang JS et al. (2004) Netrins and neogenin promote myotube formation. J Cell Biol 167: 493-504 PubMed GONUTS page
- ↑ Davie JK et al. (2007) Target gene selectivity of the myogenic basic helix-loop-helix transcription factor myogenin in embryonic muscle. Dev Biol 311: 650-64 PubMed GONUTS page
- ↑ 27.0 27.1 Cole F et al. (2004) Positive regulation of myogenic bHLH factors and skeletal muscle development by the cell surface receptor CDO. Dev Cell 7: 843-54 PubMed GONUTS page
- ↑ Hawke TJ et al. (2007) Xin, an actin binding protein, is expressed within muscle satellite cells and newly regenerated skeletal muscle fibers. Am J Physiol Cell Physiol 293: C1636-44 PubMed GONUTS page
- ↑ Long X et al. (2007) Myocardin is a bifunctional switch for smooth versus skeletal muscle differentiation. Proc Natl Acad Sci U S A 104: 16570-5 PubMed GONUTS page
- ↑ Engert JC et al. (1995) Activation of a muscle-specific enhancer by the Ski proto-oncogene. Nucleic Acids Res 23: 2988-94 PubMed GONUTS page
