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MGI:Myo6
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Myo6 ( synonyms: Tlc ) | |
| Protein Name(s) | myosin VI, | |
| External Links | ||
| MGI | MGI:104785 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0001726 |
ruffle |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3610864 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3654775 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3656369 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005524 |
ATP binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0067 |
F |
From MGI |
||
| GO:0005622 |
intracellular |
MGI:MGI:3610864 |
IPI: Inferred from Physical Interaction |
C |
From MGI |
|||
| GO:0005623 |
cell |
MGI:MGI:3654775 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856555 |
C |
From MGI |
||
| GO:0005624 |
membrane fraction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001061392 |
C |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005654 |
nucleoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001061392 |
C |
From MGI |
||
| GO:0005737 |
cytoplasm |
MGI:MGI:4430014 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005792 |
microsome |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001061392 |
C |
From MGI |
||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001061392 |
C |
From MGI |
||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:3610864 |
IPI: Inferred from Physical Interaction |
C |
From MGI |
|||
| GO:0005902 |
microvillus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001061392 |
C |
From MGI |
||
| GO:0006605 |
protein targeting |
MGI:MGI:3610864 |
IPI: Inferred from Physical Interaction |
P |
From MGI |
|||
| GO:0006897 |
endocytosis |
MGI:MGI:3527915 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856555 |
P |
From MGI |
||
| GO:0006897 |
endocytosis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007268 |
synaptic transmission |
MGI:MGI:3654775 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856555 |
P |
From MGI |
||
| GO:0007416 |
synapse assembly |
MGI:MGI:3527915 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856555 |
P |
From MGI |
||
| GO:0007605 |
sensory perception of sound |
MGI:MGI:1346380 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856555 |
P |
From MGI |
||
| GO:0007605 |
sensory perception of sound |
MGI:MGI:2150215 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007605 |
sensory perception of sound |
MGI:MGI:3527915 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856555 |
P |
From MGI |
||
| GO:0007605 |
sensory perception of sound |
MGI:MGI:3703302 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3708361 |
P |
From MGI |
||
| GO:0007605 |
sensory perception of sound |
MGI:MGI:53523 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856555 |
P |
From MGI |
||
| GO:0007605 |
sensory perception of sound |
MGI:MGI:77423 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856555 |
P |
From MGI |
||
| GO:0007605 |
sensory perception of sound |
MGI:MGI:77423 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856555 |
P |
From MGI |
||
| GO:0007626 |
locomotory behavior |
MGI:MGI:3664354 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856555 |
P |
From MGI |
||
| GO:0012506 |
vesicle membrane |
MGI:MGI:3610864 |
IPI: Inferred from Physical Interaction |
C |
From MGI |
|||
| GO:0014047 |
glutamate secretion |
MGI:MGI:3654775 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856555 |
P |
From MGI |
||
| GO:0016023 |
cytoplasmic membrane-bounded vesicle |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016358 |
dendrite development |
MGI:MGI:3527915 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856555 |
P |
From MGI |
||
| GO:0016459 |
myosin complex |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0518 |
C |
From MGI |
||
| GO:0016591 |
DNA-directed RNA polymerase II, holoenzyme |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030139 |
endocytic vesicle |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001061392 |
C |
From MGI |
||
| GO:0030330 |
DNA damage response, signal transduction by p53 class mediator |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030424 |
axon |
MGI:MGI:3654775 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0031941 |
filamentous actin |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0031965 |
nuclear membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0032587 |
ruffle membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001061392 |
C |
From MGI |
||
| GO:0042472 |
inner ear morphogenesis |
MGI:MGI:77423 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856555 |
P |
From MGI |
||
| GO:0042491 |
auditory receptor cell differentiation |
MGI:MGI:1346380 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856555 |
P |
From MGI |
||
| GO:0042491 |
auditory receptor cell differentiation |
MGI:MGI:53523 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856555 |
P |
From MGI |
||
| GO:0042491 |
auditory receptor cell differentiation |
MGI:MGI:77423 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856555 |
P |
From MGI |
||
| GO:0042493 |
response to drug |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001061392 |
P |
From MGI |
||
| GO:0043025 |
neuronal cell body |
MGI:MGI:3654775 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0043234 |
protein complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001061392 |
C |
From MGI |
||
| GO:0045177 |
apical part of cell |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001061392 |
C |
From MGI |
||
| GO:0045202 |
synapse |
MGI:MGI:3527915 |
ISO: Inferred from Sequence Orthology |
RefSeq:XP_236444 |
C |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048167 |
regulation of synaptic plasticity |
MGI:MGI:3654775 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856555 |
P |
From MGI |
||
| GO:0048471 |
perinuclear region of cytoplasm |
MGI:MGI:3527915 |
ISO: Inferred from Sequence Orthology |
RefSeq:XP_236444 |
C |
From MGI |
||
| GO:0048471 |
perinuclear region of cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0048839 |
inner ear development |
MGI:MGI:1346380 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856555 |
P |
From MGI |
||
| GO:0048839 |
inner ear development |
MGI:MGI:53523 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856555 |
P |
From MGI |
||
| GO:0048839 |
inner ear development |
MGI:MGI:77423 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856555 |
P |
From MGI |
||
| GO:0051015 |
actin filament binding |
MGI:MGI:3527915 |
ISO: Inferred from Sequence Orthology |
RefSeq:XP_236444 |
F |
From MGI |
||
| GO:0051015 |
actin filament binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0051046 |
regulation of secretion |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0071257 |
cellular response to electrical stimulus |
MGI:MGI:4849309 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Reed BC et al. (2005) GLUT1CBP(TIP2/GIPC1) interactions with GLUT1 and myosin VI: evidence supporting an adapter function for GLUT1CBP. Mol Biol Cell 16: 4183-201 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Yano H et al. (2006) BDNF-mediated neurotransmission relies upon a myosin VI motor complex. Nat Neurosci 9: 1009-18 PubMed GONUTS page
- ↑ Liu M & Horowitz A (2006) A PDZ-binding motif as a critical determinant of Rho guanine exchange factor function and cell phenotype. Mol Biol Cell 17: 1880-7 PubMed GONUTS page
- ↑ Grimsley-Myers CM et al. (2009) The small GTPase Rac1 regulates auditory hair cell morphogenesis. J Neurosci 29: 15859-69 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Osterweil E et al. (2005) A role for myosin VI in postsynaptic structure and glutamate receptor endocytosis. J Cell Biol 168: 329-38 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Self T et al. (1999) Role of myosin VI in the differentiation of cochlear hair cells. Dev Biol 214: 331-41 PubMed GONUTS page
- ↑ Melchionda S et al. (2001) MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice, is mutated in autosomal dominant nonsyndromic hearing loss. Am J Hum Genet 69: 635-40 PubMed GONUTS page
- ↑ Schwander M et al. (2007) A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function. J Neurosci 27: 2163-75 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Deol MS & Green MC (1966) Snell's waltzer, a new mutation affecting behaviour and the inner ear in the mouse. Genet Res 8: 339-45 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 10.4 Avraham KB et al. (1995) The mouse Snell's waltzer deafness gene encodes an unconventional myosin required for structural integrity of inner ear hair cells. Nat Genet 11: 369-75 PubMed GONUTS page
- ↑ Calderon A et al. (2006) Cochlear developmental defect and background-dependent hearing thresholds in the Jackson circler (jc) mutant mouse. Hear Res 221: 44-58 PubMed GONUTS page
- ↑ Won J et al. (2011) Mouse model resources for vision research. J Ophthalmol 2011: 391384 PubMed GONUTS page
