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MGI:Mylk

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Mylk ( synonyms: Mlck, MLCK108, MLCK210, telokin )
Protein Name(s) myosin, light polypeptide kinase,
External Links
MGI MGI:894806

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

From MGI

GO:0001725

stress fiber

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15746

C

From MGI

GO:0003779

actin binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0009

F

From MGI

GO:0004672

protein kinase activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR002290

F

From MGI

GO:0004674

protein serine/threonine kinase activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0723

F

From MGI

GO:0004674

protein serine/threonine kinase activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR008271

F

From MGI

GO:0004687

myosin light chain kinase activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15746

F

From MGI

GO:0005515

protein binding

MGI:MGI:3688344
PMID:15102471[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q9JMG9

F

From MGI

GO:0005516

calmodulin binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0112

F

From MGI

GO:0005524

ATP binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

From MGI

GO:0005524

ATP binding

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR017441
InterPro:IPR002290

F

From MGI

GO:0005737

cytoplasm

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15746

C

From MGI

GO:0005856

cytoskeleton

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0206

C

From MGI

GO:0006468

protein phosphorylation

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR002290
InterPro:IPR008271

P

From MGI

GO:0006468

protein phosphorylation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15746

P

From MGI

GO:0006939

smooth muscle contraction

MGI:MGI:3820013
PMID:18586037[2]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0014820

tonic smooth muscle contraction

MGI:MGI:4452414
PMID:20018858[3]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0016301

kinase activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

F

From MGI

GO:0016310

phosphorylation

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

P

From MGI

GO:0016740

transferase activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

From MGI

GO:0016772

transferase activity, transferring phosphorus-containing groups

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR011009

F

From MGI

GO:0019899

enzyme binding

MGI:MGI:4849873
PMID:21074048[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q09LZ8
UniProtKB:Q09M05
UniProtKB:Q641K1

F

From MGI

GO:0030027

lamellipodium

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15746

C

From MGI

GO:0030335

positive regulation of cell migration

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15746

P

From MGI

GO:0032060

bleb assembly

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15746

P

From MGI

GO:0032154

cleavage furrow

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15746

C

From MGI

GO:0042995

cell projection

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0966

C

From MGI

GO:0046872

metal ion binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

From MGI

GO:0051928

positive regulation of calcium ion transport

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15746

P

From MGI

GO:0060414

aorta smooth muscle tissue morphogenesis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15746

P

From MGI

GO:0071476

cellular hypotonic response

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15746

P

From MGI

GO:0090303

positive regulation of wound healing

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q15746

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Papin J & Subramaniam S (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol 15: 78-81 PubMed GONUTS page
  2. He WQ et al. (2008) Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice. Gastroenterology 135: 610-20 PubMed GONUTS page
  3. Zhang WC et al. (2010) Myosin light chain kinase is necessary for tonic airway smooth muscle contraction. J Biol Chem 285: 5522-31 PubMed GONUTS page
  4. Rogowski K et al. (2010) A family of protein-deglutamylating enzymes associated with neurodegeneration. Cell 143: 564-78 PubMed GONUTS page
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