MGI:Myd88

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0002238	response to molecule of fungal origin	MGI:MGI:3042099 PMID:12719478^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2385681	P	From MGI
	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	MGI:MGI:2670551 PMID:12872135^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2385681	P	From MGI
	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	MGI:MGI:3028810 PMID:14764662^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	MGI:MGI:3042099 PMID:12719478^[1]	IGI: Inferred from Genetic Interaction	MGI:MGI:1346060	P	From MGI
	GO:0005102	receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_937763	F	From MGI
	GO:0005121	Toll binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_937763	F	From MGI
	GO:0005149	interleukin-1 receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_937763	F	From MGI
	GO:0005515	protein binding	MGI:MGI:1889886 PMID:10854325^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q62406	F	From MGI
	GO:0005515	protein binding	MGI:MGI:2149909 PMID:11544529^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q8CFA1 UniProtKB:Q99JY1	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3608246 PMID:16236719^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q64287 UniProtKB:P56477 UniProtKB:P70434	F	From MGI
	GO:0005515	protein binding	MGI:MGI:4819286 PMID:20639876^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q3TTA7	F	From MGI
	GO:0005515	protein binding	MGI:MGI:4839450 PMID:16306937^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P70196 UniProtKB:Q60803	F	From MGI
	GO:0005515	protein binding	MGI:MGI:5002402 PMID:21441935^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P35991 UniProtKB:Q62406	F	From MGI
	GO:0005622	intracellular	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000157	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:1344119 PMID:10465784^[10]	TAS: Traceable Author Statement		C	From MGI
	GO:0005829	cytosol	MGI:MGI:4948831 PMID:16751103^[11]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:4948831 PMID:16751103^[11]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0006954	inflammatory response	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0395	P	From MGI
	GO:0006955	immune response	MGI:MGI:2152194 PMID:11526399^[12]	TAS: Traceable Author Statement		P	From MGI
	GO:0007165	signal transduction	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000488 InterPro:IPR000157	P	From MGI
	GO:0007166	cell surface receptor signaling pathway	MGI:MGI:3042099 PMID:12719478^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2385681	P	From MGI
	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	MGI:MGI:1344119 PMID:10465784^[10]	TAS: Traceable Author Statement		P	From MGI
	GO:0007254	JNK cascade	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_937763	P	From MGI
	GO:0008063	Toll signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_937763	P	From MGI
	GO:0009615	response to virus	MGI:MGI:3037412 PMID:14993594^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2385681	P	From MGI
	GO:0009615	response to virus	MGI:MGI:3575992 PMID:15800576^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2385681	P	From MGI
	GO:0014069	postsynaptic density	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_937763	C	From MGI
	GO:0016064	immunoglobulin mediated immune response	MGI:MGI:3575992 PMID:15800576^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2385681	P	From MGI
	GO:0019221	cytokine-mediated signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_937763	P	From MGI
	GO:0031663	lipopolysaccharide-mediated signaling pathway	MGI:MGI:2669022 PMID:12855817^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2385681	P	From MGI
	GO:0032494	response to peptidoglycan	MGI:MGI:3640248 PMID:10607756^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2385681	P	From MGI
	GO:0032496	response to lipopolysaccharide	MGI:MGI:2669022 PMID:12855817^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2385681	P	From MGI
	GO:0032496	response to lipopolysaccharide	MGI:MGI:2670551 PMID:12872135^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:2147032	P	From MGI
	GO:0032496	response to lipopolysaccharide	MGI:MGI:2670551 PMID:12872135^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2385681	P	From MGI
	GO:0032496	response to lipopolysaccharide	MGI:MGI:3042099 PMID:12719478^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2385681	P	From MGI
	GO:0032496	response to lipopolysaccharide	MGI:MGI:3640248 PMID:10607756^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2385681	P	From MGI
	GO:0032740	positive regulation of interleukin-17 production	MGI:MGI:3773594 PMID:18203139^[17]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0032747	positive regulation of interleukin-23 production	MGI:MGI:3773594 PMID:18203139^[17]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0032755	positive regulation of interleukin-6 production	MGI:MGI:3619313 PMID:11067888^[18]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2385681	P	From MGI
	GO:0032755	positive regulation of interleukin-6 production	MGI:MGI:3773594 PMID:18203139^[17]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0032760	positive regulation of tumor necrosis factor production	MGI:MGI:2670551 PMID:12872135^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:2147032	P	From MGI
	GO:0032760	positive regulation of tumor necrosis factor production	MGI:MGI:2670551 PMID:12872135^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2385681	P	From MGI
	GO:0032760	positive regulation of tumor necrosis factor production	MGI:MGI:3042099 PMID:12719478^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2385681	P	From MGI
	GO:0032760	positive regulation of tumor necrosis factor production	MGI:MGI:3619313 PMID:11067888^[18]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2385681	P	From MGI
	GO:0032760	positive regulation of tumor necrosis factor production	MGI:MGI:3640248 PMID:10607756^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2385681	P	From MGI
	GO:0042127	regulation of cell proliferation	MGI:MGI:3715559 PMID:17615359^[19]	IGI: Inferred from Genetic Interaction	MGI:MGI:88039	P	From MGI
	GO:0042802	identical protein binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99836	F	From MGI
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	MGI:MGI:2669022 PMID:12855817^[15]	IGI: Inferred from Genetic Interaction	MGI:MGI:2147032	P	From MGI
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	MGI:MGI:2669022 PMID:12855817^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2385681	P	From MGI
	GO:0043234	protein complex	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_937763	C	From MGI
	GO:0044130	negative regulation of growth of symbiont in host	MGI:MGI:3619313 PMID:11067888^[18]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2385681	P	From MGI
	GO:0045080	positive regulation of chemokine biosynthetic process	MGI:MGI:2669022 PMID:12855817^[15]	IGI: Inferred from Genetic Interaction	MGI:MGI:2147032	P	From MGI
	GO:0045087	innate immune response	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0399	P	From MGI
	GO:0045351	type I interferon biosynthetic process	MGI:MGI:3575992 PMID:15800576^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2385681	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_937763	P	From MGI
	GO:0046330	positive regulation of JNK cascade	MGI:MGI:2669022 PMID:12855817^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2385681	P	From MGI
	GO:0048661	positive regulation of smooth muscle cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_937763	P	From MGI
	GO:0050671	positive regulation of lymphocyte proliferation	MGI:MGI:3640248 PMID:10607756^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2385681	P	From MGI
	GO:0050727	regulation of inflammatory response	MGI:MGI:3773594 PMID:18203139^[17]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0050830	defense response to Gram-positive bacterium	MGI:MGI:3619313 PMID:11067888^[18]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2385681	P	From MGI
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	MGI:MGI:2669022 PMID:12855817^[15]	IGI: Inferred from Genetic Interaction	MGI:MGI:2147032	P	From MGI
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	MGI:MGI:2669022 PMID:12855817^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2385681	P	From MGI
	GO:0070555	response to interleukin-1	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99836	P	From MGI
	GO:0070935	3'-UTR-mediated mRNA stabilization	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99836	P	From MGI
	GO:0070976	TIR domain binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99836	F	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Brown GD et al. (2003) Dectin-1 mediates the biological effects of beta-glucans. J Exp Med 197: 1119-24 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Hoebe K et al. (2003) Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 424: 743-8 PubMed GONUTS page
↑ Hamerman JA et al. (2004) Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor. J Immunol 172: 2001-5 PubMed GONUTS page
↑ Burns K et al. (2000) Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. Nat Cell Biol 2: 346-51 PubMed GONUTS page
↑ Fitzgerald KA et al. (2001) Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 413: 78-83 PubMed GONUTS page
↑ Negishi H et al. (2005) Negative regulation of Toll-like-receptor signaling by IRF-4. Proc Natl Acad Sci U S A 102: 15989-94 PubMed GONUTS page
↑ Han C et al. (2010) Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b. Nat Immunol 11: 734-42 PubMed GONUTS page
↑ Häcker H et al. (2006) Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature 439: 204-7 PubMed GONUTS page
↑ Liu X et al. (2011) Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk. Nat Immunol 12: 416-24 PubMed GONUTS page
↑ ^10.0 ^10.1 Kopp E et al. (1999) ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes Dev 13: 2059-71 PubMed GONUTS page
↑ ^11.0 ^11.1 Kagan JC & Medzhitov R (2006) Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell 125: 943-55 PubMed GONUTS page
↑ Horng T et al. (2001) TIRAP: an adapter molecule in the Toll signaling pathway. Nat Immunol 2: 835-41 PubMed GONUTS page
↑ Tabeta K et al. (2004) Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc Natl Acad Sci U S A 101: 3516-21 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Honda K et al. (2005) IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 434: 772-7 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 ^15.7 Yamamoto M et al. (2003) Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301: 640-3 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Takeuchi O et al. (2000) Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades. Int Immunol 12: 113-7 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Marta M et al. (2008) Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitis. Eur J Immunol 38: 565-75 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 Takeuchi O et al. (2000) Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J Immunol 165: 5392-6 PubMed GONUTS page
↑ Rakoff-Nahoum S & Medzhitov R (2007) Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science 317: 124-7 PubMed GONUTS page

[PMID:12719478-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Brown GD et al. (2003) Dectin-1 mediates the biological effects of beta-glucans. J Exp Med 197: 1119-24 PubMed GONUTS page

[PMID:12872135-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Hoebe K et al. (2003) Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 424: 743-8 PubMed GONUTS page

[PMID:14764662-2] Hamerman JA et al. (2004) Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor. J Immunol 172: 2001-5 PubMed GONUTS page

[PMID:10854325-3] Burns K et al. (2000) Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. Nat Cell Biol 2: 346-51 PubMed GONUTS page

[PMID:11544529-4] Fitzgerald KA et al. (2001) Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 413: 78-83 PubMed GONUTS page

[PMID:16236719-5] Negishi H et al. (2005) Negative regulation of Toll-like-receptor signaling by IRF-4. Proc Natl Acad Sci U S A 102: 15989-94 PubMed GONUTS page

[PMID:20639876-6] Han C et al. (2010) Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b. Nat Immunol 11: 734-42 PubMed GONUTS page

[PMID:16306937-7] Häcker H et al. (2006) Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature 439: 204-7 PubMed GONUTS page

[PMID:21441935-8] Liu X et al. (2011) Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk. Nat Immunol 12: 416-24 PubMed GONUTS page

[PMID:10465784-9] 10.0 ^10.1 Kopp E et al. (1999) ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes Dev 13: 2059-71 PubMed GONUTS page

[PMID:16751103-10] 11.0 ^11.1 Kagan JC & Medzhitov R (2006) Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell 125: 943-55 PubMed GONUTS page

[PMID:11526399-11] Horng T et al. (2001) TIRAP: an adapter molecule in the Toll signaling pathway. Nat Immunol 2: 835-41 PubMed GONUTS page

[PMID:14993594-12] Tabeta K et al. (2004) Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc Natl Acad Sci U S A 101: 3516-21 PubMed GONUTS page

[PMID:15800576-13] 14.0 ^14.1 ^14.2 Honda K et al. (2005) IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 434: 772-7 PubMed GONUTS page

[PMID:12855817-14] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 ^15.7 Yamamoto M et al. (2003) Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301: 640-3 PubMed GONUTS page

[PMID:10607756-15] 16.0 ^16.1 ^16.2 ^16.3 Takeuchi O et al. (2000) Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades. Int Immunol 12: 113-7 PubMed GONUTS page

[PMID:18203139-16] 17.0 ^17.1 ^17.2 ^17.3 Marta M et al. (2008) Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitis. Eur J Immunol 38: 565-75 PubMed GONUTS page

[PMID:11067888-17] 18.0 ^18.1 ^18.2 ^18.3 Takeuchi O et al. (2000) Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J Immunol 165: 5392-6 PubMed GONUTS page

[PMID:17615359-18] Rakoff-Nahoum S & Medzhitov R (2007) Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science 317: 124-7 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Myd88
Protein Name(s)	myeloid differentiation primary response gene 88,
External Links
MGI	MGI:108005

MGI:Myd88

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