MGI:Myc

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:2386345 PMID:12196193^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P09416	P	From MGI
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	P	From MGI
	GO:0000165	MAPK cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	P	From MGI
	GO:0001658	branching involved in ureteric bud morphogenesis	MGI:MGI:3830398 PMID:19161241^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0001783	B cell apoptotic process	MGI:MGI:3692035 PMID:12970677^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1931143	P	From MGI
	GO:0001836	release of cytochrome c from mitochondria	MGI:MGI:2677658 PMID:14517295^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0002053	positive regulation of mesenchymal cell proliferation	MGI:MGI:3830398 PMID:19161241^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0002904	positive regulation of B cell apoptotic process	MGI:MGI:2152245 PMID:11604501^[5]	IGI: Inferred from Genetic Interaction	MGI:MGI:99702	P	From MGI
	GO:0003677	DNA binding	MGI:MGI:2675510 PMID:12970171^[6]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003677	DNA binding	MGI:MGI:2679173 PMID:14560010^[7]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003677	DNA binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P09416	F	From MGI
	GO:0003690	double-stranded DNA binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P09416	F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P09416	F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3836317 PMID:19269368^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q8CH72	F	From MGI
	GO:0005515	protein binding	MGI:MGI:4839428 PMID:20434984^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P28574	F	From MGI
	GO:0005515	protein binding	MGI:MGI:4889165 PMID:20946988^[10]	IPI: Inferred from Physical Interaction	UniProtKB:P28574	F	From MGI
	GO:0005515	protein binding	MGI:MGI:5142396 PMID:9764821^[11]	IPI: Inferred from Physical Interaction	UniProtKB:P28574	F	From MGI
	GO:0005515	protein binding	MGI:MGI:5294288 PMID:18438430^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P06803	F	From MGI
	GO:0005634	nucleus	MGI:MGI:2159585 PMID:11872843^[13]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3582894 PMID:15994933^[14]	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	C	From MGI
	GO:0005634	nucleus	MGI:MGI:3721205 PMID:17631878^[15]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4367296 PMID:19796622^[16]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P09416	C	From MGI
	GO:0005634	nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	C	From MGI
	GO:0005654	nucleoplasm	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	C	From MGI
	GO:0005730	nucleolus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P09416	C	From MGI
	GO:0005730	nucleolus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P09416	C	From MGI
	GO:0005819	spindle	MGI:MGI:3056244 PMID:15509711^[17]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0006006	glucose metabolic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P09416	P	From MGI
	GO:0006309	DNA fragmentation involved in apoptotic nuclear change	MGI:MGI:2677658 PMID:14517295^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006338	chromatin remodeling	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	P	From MGI
	GO:0006351	transcription, DNA-dependent	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P09416	P	From MGI
	GO:0006352	transcription initiation, DNA-dependent	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P09416	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P09416	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:77472 PMID:8521822^[18]	IGI: Inferred from Genetic Interaction	MGI:MGI:104991 MGI:MGI:104987 MGI:MGI:96921	P	From MGI
	GO:0006366	transcription from RNA polymerase II promoter	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P09416	P	From MGI
	GO:0006879	cellular iron ion homeostasis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	P	From MGI
	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	MGI:MGI:2677658 PMID:14517295^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006974	response to DNA damage stimulus	MGI:MGI:4439432 PMID:20212154^[19]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006974	response to DNA damage stimulus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	P	From MGI
	GO:0007050	cell cycle arrest	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	P	From MGI
	GO:0007346	regulation of mitotic cell cycle	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P09416	P	From MGI
	GO:0008134	transcription factor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	F	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:2386811 PMID:12235125^[20]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:2677658 PMID:14517295^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:3582894 PMID:15994933^[14]	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:3720546 PMID:17596282^[21]	IGI: Inferred from Genetic Interaction	MGI:MGI:88039	P	From MGI
	GO:0008629	induction of apoptosis by intracellular signals	MGI:MGI:2677658 PMID:14517295^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0008629	induction of apoptosis by intracellular signals	MGI:MGI:2677658 PMID:14517295^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2447604	P	From MGI
	GO:0008633	activation of pro-apoptotic gene products	MGI:MGI:2677658 PMID:14517295^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0008633	activation of pro-apoptotic gene products	MGI:MGI:2677658 PMID:14517295^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2447604	P	From MGI
	GO:0008634	negative regulation of survival gene product expression	MGI:MGI:2677658 PMID:14517295^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0008634	negative regulation of survival gene product expression	MGI:MGI:2677658 PMID:14517295^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2447604	P	From MGI
	GO:0009314	response to radiation	MGI:MGI:2677658 PMID:14517295^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0009314	response to radiation	MGI:MGI:2677658 PMID:14517295^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2447604	P	From MGI
	GO:0010332	response to gamma radiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	P	From MGI
	GO:0010468	regulation of gene expression	MGI:MGI:2137142 PMID:11438662^[22]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0016055	Wnt receptor signaling pathway	MGI:MGI:3820325 PMID:19056892^[23]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0016485	protein processing	MGI:MGI:3692035 PMID:12970677^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1931143	P	From MGI
	GO:0016604	nuclear body	MGI:MGI:3574687 PMID:15735755^[24]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0030424	axon	MGI:MGI:1344237 PMID:10482234^[25]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0032091	negative regulation of protein binding	MGI:MGI:3773503 PMID:18045875^[26]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0032204	regulation of telomere maintenance	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	P	From MGI
	GO:0032403	protein complex binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	F	From MGI
	GO:0035690	cellular response to drug	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	P	From MGI
	GO:0035690	cellular response to drug	MGI:MGI:5306576 PMID:19179467^[27]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0042474	middle ear morphogenesis	MGI:MGI:3712581 PMID:17523175^[28]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2178233 MGI:MGI:2386570	P	From MGI
	GO:0042981	regulation of apoptotic process	MGI:MGI:2386811 PMID:12235125^[20]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0043085	positive regulation of catalytic activity	MGI:MGI:3721729 PMID:17382917^[29]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0043234	protein complex	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	C	From MGI
	GO:0043279	response to alkaloid	MGI:MGI:3692035 PMID:12970677^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1931143	P	From MGI
	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	P	From MGI
	GO:0043473	pigmentation	MGI:MGI:3712581 PMID:17523175^[28]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2178233 MGI:MGI:2386570	P	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P09416	F	From MGI
	GO:0045656	negative regulation of monocyte differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P09416	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3721729 PMID:17382917^[29]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P09416	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	P	From MGI
	GO:0046982	protein heterodimerization activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P09416	F	From MGI
	GO:0048146	positive regulation of fibroblast proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	P	From MGI
	GO:0048147	negative regulation of fibroblast proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	P	From MGI
	GO:0048705	skeletal system morphogenesis	MGI:MGI:3712581 PMID:17523175^[28]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2178233 MGI:MGI:2386570	P	From MGI
	GO:0050679	positive regulation of epithelial cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	P	From MGI
	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	MGI:MGI:3712581 PMID:17523175^[28]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2178233 MGI:MGI:2386570	P	From MGI
	GO:0051276	chromosome organization	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	P	From MGI
	GO:0051782	negative regulation of cell division	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	P	From MGI
	GO:0060070	canonical Wnt receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	P	From MGI
	GO:0070491	repressing transcription factor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	F	From MGI
	GO:0070888	E-box binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	F	From MGI
	GO:0090096	positive regulation of metanephric cap mesenchymal cell proliferation	MGI:MGI:3830398 PMID:19161241^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:2000573	positive regulation of DNA biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	P	From MGI
	GO:2001022	positive regulation of response to DNA damage stimulus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	P	From MGI
	GO:2001220	negative regulation of G2 phase of mitotic cell cycle	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01106	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Bowen H et al. (2002) c-Myc represses the murine Nramp1 promoter. Biochem Soc Trans 30: 774-7 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Couillard M & Trudel M (2009) C-myc as a modulator of renal stem/progenitor cell population. Dev Dyn 238: 405-14 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 de Alborán IM et al. (2004) c-Myc-deficient B lymphocytes are resistant to spontaneous and induced cell death. Cell Death Differ 11: 61-8 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 Maclean KH et al. (2003) c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL. Mol Cell Biol 23: 7256-70 PubMed GONUTS page
↑ Eischen CM et al. (2001) Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis. Mol Cell Biol 21: 7653-62 PubMed GONUTS page
↑ Hurlin PJ et al. (2003) Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis. EMBO J 22: 4584-96 PubMed GONUTS page
↑ Adhikary S et al. (2003) Miz1 is required for early embryonic development during gastrulation. Mol Cell Biol 23: 7648-57 PubMed GONUTS page
↑ Schwamborn JC et al. (2009) The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors. Cell 136: 913-25 PubMed GONUTS page
↑ Rahl PB et al. (2010) c-Myc regulates transcriptional pause release. Cell 141: 432-45 PubMed GONUTS page
↑ Kim J et al. (2010) A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell 143: 313-24 PubMed GONUTS page
↑ Yuan J et al. (1998) The C. elegans MDL-1 and MXL-1 proteins can functionally substitute for vertebrate MAD and MAX. Oncogene 17: 1109-18 PubMed GONUTS page
↑ Zhang Y et al. (2008) Pim kinase-dependent inhibition of c-Myc degradation. Oncogene 27: 4809-19 PubMed GONUTS page
↑ Velcich A et al. (2002) Colorectal cancer in mice genetically deficient in the mucin Muc2. Science 295: 1726-9 PubMed GONUTS page
↑ ^14.0 ^14.1 Huang A et al. (2005) Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells. Cancer Res 65: 5607-19 PubMed GONUTS page
↑ Nieuwenhuis E et al. (2007) Epidermal hyperplasia and expansion of the interfollicular stem cell compartment in mutant mice with a C-terminal truncation of Patched1. Dev Biol 308: 547-60 PubMed GONUTS page
↑ Nishiyama A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5: 420-33 PubMed GONUTS page
↑ Liu J et al. (2004) Serine-threonine kinases and transcription factors active in signal transduction are detected at high levels of phosphorylation during mitosis in preimplantation embryos and trophoblast stem cells. Reproduction 128: 643-54 PubMed GONUTS page
↑ Hurlin PJ et al. (1995) Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. EMBO J 14: 5646-59 PubMed GONUTS page
↑ Cannell IG et al. (2010) p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication. Proc Natl Acad Sci U S A 107: 5375-80 PubMed GONUTS page
↑ ^20.0 ^20.1 Widlund HR et al. (2002) Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor. J Cell Biol 158: 1079-87 PubMed GONUTS page
↑ Strom A et al. (2007) Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas. Development 134: 2719-25 PubMed GONUTS page
↑ Eischen CM et al. (2001) Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis. Mol Cell Biol 21: 5063-70 PubMed GONUTS page
↑ Miranda-Carboni GA et al. (2008) A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev 22: 3121-34 PubMed GONUTS page
↑ Cairo S et al. (2005) PML interacts with Myc, and Myc target gene expression is altered in PML-null fibroblasts. Oncogene 24: 2195-203 PubMed GONUTS page
↑ Arber S et al. (1999) Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity. Neuron 23: 659-74 PubMed GONUTS page
↑ Alter-Koltunoff M et al. (2008) Innate immunity to intraphagosomal pathogens is mediated by interferon regulatory factor 8 (IRF-8) that stimulates the expression of macrophage-specific Nramp1 through antagonizing repression by c-Myc. J Biol Chem 283: 2724-33 PubMed GONUTS page
↑ Höglund A et al. (2009) Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine. Blood 113: 4281-8 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 ^28.3 Wei K et al. (2007) Neural crest cell deficiency of c-myc causes skull and hearing defects. Genesis 45: 382-90 PubMed GONUTS page
↑ ^29.0 ^29.1 Hou Y et al. (2007) c-Myc is essential for urokinase plasminogen activator expression on hypoxia-induced vascular smooth muscle cells. Cardiovasc Res 75: 186-94 PubMed GONUTS page

[PMID:12196193-0] Bowen H et al. (2002) c-Myc represses the murine Nramp1 promoter. Biochem Soc Trans 30: 774-7 PubMed GONUTS page

[PMID:19161241-1] 2.0 ^2.1 ^2.2 Couillard M & Trudel M (2009) C-myc as a modulator of renal stem/progenitor cell population. Dev Dyn 238: 405-14 PubMed GONUTS page

[PMID:12970677-2] 3.0 ^3.1 ^3.2 de Alborán IM et al. (2004) c-Myc-deficient B lymphocytes are resistant to spontaneous and induced cell death. Cell Death Differ 11: 61-8 PubMed GONUTS page

[PMID:14517295-3] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 Maclean KH et al. (2003) c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL. Mol Cell Biol 23: 7256-70 PubMed GONUTS page

[PMID:11604501-4] Eischen CM et al. (2001) Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis. Mol Cell Biol 21: 7653-62 PubMed GONUTS page

[PMID:12970171-5] Hurlin PJ et al. (2003) Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis. EMBO J 22: 4584-96 PubMed GONUTS page

[PMID:14560010-6] Adhikary S et al. (2003) Miz1 is required for early embryonic development during gastrulation. Mol Cell Biol 23: 7648-57 PubMed GONUTS page

[PMID:19269368-7] Schwamborn JC et al. (2009) The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors. Cell 136: 913-25 PubMed GONUTS page

[PMID:20434984-8] Rahl PB et al. (2010) c-Myc regulates transcriptional pause release. Cell 141: 432-45 PubMed GONUTS page

[PMID:20946988-9] Kim J et al. (2010) A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell 143: 313-24 PubMed GONUTS page

[PMID:9764821-10] Yuan J et al. (1998) The C. elegans MDL-1 and MXL-1 proteins can functionally substitute for vertebrate MAD and MAX. Oncogene 17: 1109-18 PubMed GONUTS page

[PMID:18438430-11] Zhang Y et al. (2008) Pim kinase-dependent inhibition of c-Myc degradation. Oncogene 27: 4809-19 PubMed GONUTS page

[PMID:11872843-12] Velcich A et al. (2002) Colorectal cancer in mice genetically deficient in the mucin Muc2. Science 295: 1726-9 PubMed GONUTS page

[PMID:15994933-13] 14.0 ^14.1 Huang A et al. (2005) Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells. Cancer Res 65: 5607-19 PubMed GONUTS page

[PMID:17631878-14] Nieuwenhuis E et al. (2007) Epidermal hyperplasia and expansion of the interfollicular stem cell compartment in mutant mice with a C-terminal truncation of Patched1. Dev Biol 308: 547-60 PubMed GONUTS page

[PMID:19796622-15] Nishiyama A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5: 420-33 PubMed GONUTS page

[PMID:15509711-16] Liu J et al. (2004) Serine-threonine kinases and transcription factors active in signal transduction are detected at high levels of phosphorylation during mitosis in preimplantation embryos and trophoblast stem cells. Reproduction 128: 643-54 PubMed GONUTS page

[PMID:8521822-17] Hurlin PJ et al. (1995) Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. EMBO J 14: 5646-59 PubMed GONUTS page

[PMID:20212154-18] Cannell IG et al. (2010) p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication. Proc Natl Acad Sci U S A 107: 5375-80 PubMed GONUTS page

[PMID:12235125-19] 20.0 ^20.1 Widlund HR et al. (2002) Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor. J Cell Biol 158: 1079-87 PubMed GONUTS page

[PMID:17596282-20] Strom A et al. (2007) Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas. Development 134: 2719-25 PubMed GONUTS page

[PMID:11438662-21] Eischen CM et al. (2001) Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis. Mol Cell Biol 21: 5063-70 PubMed GONUTS page

[PMID:19056892-22] Miranda-Carboni GA et al. (2008) A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev 22: 3121-34 PubMed GONUTS page

[PMID:15735755-23] Cairo S et al. (2005) PML interacts with Myc, and Myc target gene expression is altered in PML-null fibroblasts. Oncogene 24: 2195-203 PubMed GONUTS page

[PMID:10482234-24] Arber S et al. (1999) Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity. Neuron 23: 659-74 PubMed GONUTS page

[PMID:18045875-25] Alter-Koltunoff M et al. (2008) Innate immunity to intraphagosomal pathogens is mediated by interferon regulatory factor 8 (IRF-8) that stimulates the expression of macrophage-specific Nramp1 through antagonizing repression by c-Myc. J Biol Chem 283: 2724-33 PubMed GONUTS page

[PMID:19179467-26] Höglund A et al. (2009) Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine. Blood 113: 4281-8 PubMed GONUTS page

[PMID:17523175-27] 28.0 ^28.1 ^28.2 ^28.3 Wei K et al. (2007) Neural crest cell deficiency of c-myc causes skull and hearing defects. Genesis 45: 382-90 PubMed GONUTS page

[PMID:17382917-28] 29.0 ^29.1 Hou Y et al. (2007) c-Myc is essential for urokinase plasminogen activator expression on hypoxia-induced vascular smooth muscle cells. Cardiovasc Res 75: 186-94 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Myc ( synonyms: bHLHe39, c-myc, Myc2, Niard, Nird )
Protein Name(s)	myelocytomatosis oncogene,
External Links
MGI	MGI:97250

MGI:Myc

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