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MGI:Mybpc3
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Mybpc3 ( synonyms: cardiac C-protein ) | |
| Protein Name(s) | myosin binding protein C, cardiac, | |
| External Links | ||
| MGI | MGI:102844 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0002027 |
regulation of heart rate |
MGI:MGI:1352072 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0003007 |
heart morphogenesis |
MGI:MGI:1347180 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2654420 |
P |
From MGI |
||
| GO:0003007 |
heart morphogenesis |
MGI:MGI:1352072 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0003007 |
heart morphogenesis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0005200 |
structural constituent of cytoskeleton |
MGI:MGI:80083 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0005856 |
cytoskeleton |
MGI:MGI:80083 |
TAS: Traceable Author Statement |
C |
From MGI |
|||
| GO:0005863 |
striated muscle myosin thick filament |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005863 |
striated muscle myosin thick filament |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006936 |
muscle contraction |
MGI:MGI:80083 |
IPI: Inferred from Physical Interaction |
P |
From MGI |
|||
| GO:0008016 |
regulation of heart contraction |
MGI:MGI:3580188 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2654420 |
P |
From MGI |
||
| GO:0008016 |
regulation of heart contraction |
MGI:MGI:3607201 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3526881 |
P |
From MGI |
||
| GO:0008016 |
regulation of heart contraction |
MGI:MGI:3628863 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3526881 |
P |
From MGI |
||
| GO:0008307 |
structural constituent of muscle |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0017022 |
myosin binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030016 |
myofibril |
MGI:MGI:1347180 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030017 |
sarcomere |
MGI:MGI:3695637 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030017 |
sarcomere |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0031034 |
myosin filament assembly |
MGI:MGI:3710921 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3526881 |
P |
From MGI |
||
| GO:0031672 |
A band |
MGI:MGI:1352072 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0031672 |
A band |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0032036 |
myosin heavy chain binding |
MGI:MGI:3695637 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0032036 |
myosin heavy chain binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0045214 |
sarcomere organization |
MGI:MGI:3616388 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3606208 |
P |
From MGI |
||
| GO:0045214 |
sarcomere organization |
MGI:MGI:3695637 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2654420 |
P |
From MGI |
||
| GO:0045214 |
sarcomere organization |
MGI:MGI:3696622 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2654420 |
P |
From MGI |
||
| GO:0055010 |
ventricular cardiac muscle tissue morphogenesis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060048 |
cardiac muscle contraction |
MGI:MGI:3616388 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3606208 |
P |
From MGI |
||
| GO:0060048 |
cardiac muscle contraction |
MGI:MGI:3696622 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2654420 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Yang Q et al. (1999) In vivo modeling of myosin binding protein C familial hypertrophic cardiomyopathy. Circ Res 85: 841-7 PubMed GONUTS page
- ↑ 2.0 2.1 McConnell BK et al. (1999) Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice. J Clin Invest 104: 1235-44 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Schiaffino S & Reggiani C (1996) Molecular diversity of myofibrillar proteins: gene regulation and functional significance. Physiol Rev 76: 371-423 PubMed GONUTS page
- ↑ Palmer BM et al. (2004) Role of cardiac myosin binding protein C in sustaining left ventricular systolic stiffening. Circ Res 94: 1249-55 PubMed GONUTS page
- ↑ Harris SP et al. (2004) Binding of myosin binding protein-C to myosin subfragment S2 affects contractility independent of a tether mechanism. Circ Res 95: 930-6 PubMed GONUTS page
- ↑ Korte FS et al. (2003) Loaded shortening, power output, and rate of force redevelopment are increased with knockout of cardiac myosin binding protein-C. Circ Res 93: 752-8 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Sadayappan S et al. (2006) Cardiac myosin binding protein C phosphorylation is cardioprotective. Proc Natl Acad Sci U S A 103: 16918-23 PubMed GONUTS page
- ↑ Colson BA et al. (2007) Radial displacement of myosin cross-bridges in mouse myocardium due to ablation of myosin binding protein-C. J Mol Biol 367: 36-41 PubMed GONUTS page
- ↑ 9.0 9.1 Cazorla O et al. (2006) Length and protein kinase A modulations of myocytes in cardiac myosin binding protein C-deficient mice. Cardiovasc Res 69: 370-80 PubMed GONUTS page
- ↑ 10.0 10.1 Sadayappan S et al. (2005) Cardiac myosin-binding protein-C phosphorylation and cardiac function. Circ Res 97: 1156-63 PubMed GONUTS page
