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MGI:Musk
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Musk ( synonyms: MDK4, Nsk1, Nsk2, Nsk3 ) | |
| Protein Name(s) | muscle, skeletal, receptor tyrosine kinase, | |
| External Links | ||
| MGI | MGI:103581 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0001934 |
positive regulation of protein phosphorylation |
MGI:MGI:2680892 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0001934 |
positive regulation of protein phosphorylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0004672 |
protein kinase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004713 |
protein tyrosine kinase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004714 |
transmembrane receptor protein tyrosine kinase activity |
MGI:MGI:74858 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:2384358 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2680892 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2686780 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3715433 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3834767 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3835221 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4820894 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:5142162 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005524 |
ATP binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0067 |
F |
From MGI |
||
| GO:0005524 |
ATP binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:2686780 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005887 |
integral to plasma membrane |
MGI:MGI:3835221 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005887 |
integral to plasma membrane |
MGI:MGI:74858 |
TAS: Traceable Author Statement |
C |
From MGI |
|||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:1337707 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1929066 |
P |
From MGI |
||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0217 |
P |
From MGI |
||
| GO:0007528 |
neuromuscular junction development |
MGI:MGI:2384358 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:94941 |
P |
From MGI |
||
| GO:0007528 |
neuromuscular junction development |
MGI:MGI:3630229 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:3584043 |
P |
From MGI |
||
| GO:0007613 |
memory |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008582 |
regulation of synaptic growth at neuromuscular junction |
MGI:MGI:80613 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1929066 |
P |
From MGI |
||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0010628 |
positive regulation of gene expression |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010629 |
negative regulation of gene expression |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0016301 |
kinase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
F |
From MGI |
||
| GO:0016310 |
phosphorylation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
P |
From MGI |
||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0019901 |
protein kinase binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030054 |
cell junction |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0965 |
C |
From MGI |
||
| GO:0030154 |
cell differentiation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0221 |
P |
From MGI |
||
| GO:0030165 |
PDZ domain binding |
MGI:MGI:3790051 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0031594 |
neuromuscular junction |
MGI:MGI:3703100 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0031594 |
neuromuscular junction |
MGI:MGI:3835221 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0031594 |
neuromuscular junction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0032224 |
positive regulation of synaptic transmission, cholinergic |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042995 |
cell projection |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043113 |
receptor clustering |
MGI:MGI:1935007 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1929066 |
P |
From MGI |
||
| GO:0043113 |
receptor clustering |
MGI:MGI:2384358 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:94941 |
P |
From MGI |
||
| GO:0043113 |
receptor clustering |
MGI:MGI:3630229 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:3584043 |
P |
From MGI |
||
| GO:0043113 |
receptor clustering |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043525 |
positive regulation of neuron apoptotic process |
MGI:MGI:2137500 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1929066 |
P |
From MGI |
||
| GO:0045202 |
synapse |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0770 |
C |
From MGI |
||
| GO:0045211 |
postsynaptic membrane |
MGI:MGI:3835221 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0045887 |
positive regulation of synaptic growth at neuromuscular junction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046777 |
protein autophosphorylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051602 |
response to electrical stimulus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060291 |
long-term synaptic potentiation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0071340 |
skeletal muscle acetylcholine-gated channel clustering |
MGI:MGI:2663717 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:2000541 |
positive regulation of protein geranylgeranylation |
MGI:MGI:2680892 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Luo ZG et al. (2003) Implication of geranylgeranyltransferase I in synapse formation. Neuron 40: 703-17 PubMed GONUTS page
- ↑ 2.0 2.1 Ganju P et al. (1995) Cloning and developmental expression of Nsk2, a novel receptor tyrosine kinase implicated in skeletal myogenesis. Oncogene 11: 281-90 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Luo ZG et al. (2002) Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1. Neuron 35: 489-505 PubMed GONUTS page
- ↑ 4.0 4.1 Bromann PA et al. (2004) A putative ariadne-like E3 ubiquitin ligase (PAUL) that interacts with the muscle-specific kinase (MuSK). Gene Expr Patterns 4: 77-84 PubMed GONUTS page
- ↑ Jones N et al. (2007) Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase. Mol Cell Biol 27: 4759-73 PubMed GONUTS page
- ↑ Kim N et al. (2008) Lrp4 is a receptor for Agrin and forms a complex with MuSK. Cell 135: 334-42 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Linnoila J et al. (2008) A mammalian homolog of Drosophila tumorous imaginal discs, Tid1, mediates agrin signaling at the neuromuscular junction. Neuron 60: 625-41 PubMed GONUTS page
- ↑ Bergamin E et al. (2010) The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization. Mol Cell 39: 100-9 PubMed GONUTS page
- ↑ Woller B et al. (2011) Rin-like, a novel regulator of endocytosis, acts as guanine nucleotide exchange factor for Rab5a and Rab22. Biochim Biophys Acta 1813: 1198-210 PubMed GONUTS page
- ↑ Gautam M et al. (1999) Distinct phenotypes of mutant mice lacking agrin, MuSK, or rapsyn. Brain Res Dev Brain Res 114: 171-8 PubMed GONUTS page
- ↑ 11.0 11.1 Okada K et al. (2006) The muscle protein Dok-7 is essential for neuromuscular synaptogenesis. Science 312: 1802-5 PubMed GONUTS page
- ↑ DeChiara TM et al. (1996) The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo. Cell 85: 501-12 PubMed GONUTS page
- ↑ Lu Z et al. (2007) Regulation of synaptic growth and maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junction. J Cell Biol 177: 1077-89 PubMed GONUTS page
- ↑ Weatherbee SD et al. (2006) LDL-receptor-related protein 4 is crucial for formation of the neuromuscular junction. Development 133: 4993-5000 PubMed GONUTS page
- ↑ Yang X et al. (2001) Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation. Neuron 30: 399-410 PubMed GONUTS page
- ↑ Terrado J et al. (2001) Motoneuron survival is enhanced in the absence of neuromuscular junction formation in embryos. J Neurosci 21: 3144-50 PubMed GONUTS page
- ↑ Lin W et al. (2001) Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapse. Nature 410: 1057-64 PubMed GONUTS page
