MGI:Mtor

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000166	nucleotide binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0547	F	From MGI
	GO:0001030	RNA polymerase III type 1 promoter DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P42345	F	From MGI
	GO:0001031	RNA polymerase III type 2 promoter DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P42345	F	From MGI
	GO:0001032	RNA polymerase III type 3 promoter DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P42345	F	From MGI
	GO:0001156	TFIIIC-class transcription factor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P42345	F	From MGI
	GO:0001934	positive regulation of protein phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P42345	P	From MGI
	GO:0001938	positive regulation of endothelial cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P42346	P	From MGI
	GO:0004674	protein serine/threonine kinase activity	MGI:MGI:3512675 PMID:11707573^[1]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004674	protein serine/threonine kinase activity	MGI:MGI:3795069 PMID:18347059^[2]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004674	protein serine/threonine kinase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P42346	F	From MGI
	GO:0004674	protein serine/threonine kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P42345	F	From MGI
	GO:0004674	protein serine/threonine kinase activity	MGI:MGI:5285135 PMID:21258367^[3]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005515	protein binding	MGI:MGI:3654795 PMID:16915281^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q60953	F	From MGI
	GO:0005515	protein binding	MGI:MGI:4456956 PMID:12150926^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q13541 UniProtKB:Q8N122	F	From MGI
	GO:0005515	protein binding	MGI:MGI:4830417 PMID:20801936^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q6QI06 UniProtKB:Q8K4Q0	F	From MGI
	GO:0005515	protein binding	MGI:MGI:4867369 PMID:21045808^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P12970 UniProtKB:Q6QI06	F	From MGI
	GO:0005515	protein binding	MGI:MGI:5285135 PMID:21258367^[3]	IPI: Inferred from Physical Interaction	UniProtKB:O70405	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0067	F	From MGI
	GO:0005625	soluble fraction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P42346	C	From MGI
	GO:0005634	nucleus	MGI:MGI:3778268 PMID:18381428^[8]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3795069 PMID:18347059^[2]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P42346	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P42345	C	From MGI
	GO:0005739	mitochondrion	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0496	C	From MGI
	GO:0005741	mitochondrial outer membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-1000	C	From MGI
	GO:0005764	lysosome	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P42345	C	From MGI
	GO:0005783	endoplasmic reticulum	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0256	C	From MGI
	GO:0005794	Golgi apparatus	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0333	C	From MGI
	GO:0005829	cytosol	MGI:MGI:3654795 PMID:16915281^[4]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005829	cytosol	MGI:MGI:3795069 PMID:18347059^[2]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005829	cytosol	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P42346	C	From MGI
	GO:0005979	regulation of glycogen biosynthetic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P42346	P	From MGI
	GO:0006109	regulation of carbohydrate metabolic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P42346	P	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:3510095 PMID:15467718^[9]	ISO: Inferred from Sequence Orthology	UniProtKB:P42345	P	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P42346	P	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P42345	P	From MGI
	GO:0007281	germ cell development	MGI:MGI:2384228 PMID:12140361^[10]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0008152	metabolic process	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0808	P	From MGI
	GO:0008152	metabolic process	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000403 InterPro:IPR018936	P	From MGI
	GO:0010507	negative regulation of autophagy	MGI:MGI:5285135 PMID:21258367^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0010592	positive regulation of lamellipodium assembly	MGI:MGI:3510095 PMID:15467718^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0012505	endomembrane system	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P42345	C	From MGI
	GO:0016020	membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P42345	C	From MGI
	GO:0016049	cell growth	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P42345	P	From MGI
	GO:0016242	negative regulation of macroautophagy	MGI:MGI:3690270 PMID:16714284^[11]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0016301	kinase activity	MGI:MGI:3510095 PMID:15467718^[9]	ISO: Inferred from Sequence Orthology	UniProtKB:P42345	F	From MGI
	GO:0016310	phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P42345	P	From MGI
	GO:0016740	transferase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0808	F	From MGI
	GO:0016772	transferase activity, transferring phosphorus-containing groups	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR009076 InterPro:IPR011009	F	From MGI
	GO:0016773	phosphotransferase activity, alcohol group as acceptor	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000403 InterPro:IPR018936	F	From MGI
	GO:0018105	peptidyl-serine phosphorylation	MGI:MGI:3795069 PMID:18347059^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0018105	peptidyl-serine phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P42345	P	From MGI
	GO:0018107	peptidyl-threonine phosphorylation	MGI:MGI:3512675 PMID:11707573^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0019904	protein domain specific binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P42346	F	From MGI
	GO:0030030	cell projection organization	MGI:MGI:3610880 PMID:16286931^[12]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0030030	cell projection organization	MGI:MGI:3610880 PMID:16286931^[12]	ISO: Inferred from Sequence Orthology	UniProtKB:P42346	P	From MGI
	GO:0030838	positive regulation of actin filament polymerization	MGI:MGI:3510095 PMID:15467718^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0030838	positive regulation of actin filament polymerization	MGI:MGI:3510095 PMID:15467718^[9]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0031529	ruffle organization	MGI:MGI:3510095 PMID:15467718^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0031669	cellular response to nutrient levels	MGI:MGI:5285135 PMID:21258367^[3]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0031929	TOR signaling cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P42345	P	From MGI
	GO:0031931	TORC1 complex	MGI:MGI:3510095 PMID:15467718^[9]	ISO: Inferred from Sequence Orthology	UniProtKB:P42345	C	From MGI
	GO:0031931	TORC1 complex	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P42346	C	From MGI
	GO:0031931	TORC1 complex	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P42345	C	From MGI
	GO:0031932	TORC2 complex	MGI:MGI:3510095 PMID:15467718^[9]	ISO: Inferred from Sequence Orthology	UniProtKB:P42345	C	From MGI
	GO:0031932	TORC2 complex	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P42345	C	From MGI
	GO:0031998	regulation of fatty acid beta-oxidation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P42346	P	From MGI
	GO:0032095	regulation of response to food	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P42346	P	From MGI
	GO:0032314	regulation of Rac GTPase activity	MGI:MGI:3510095 PMID:15467718^[9]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0032868	response to insulin stimulus	MGI:MGI:3510095 PMID:15467718^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0032956	regulation of actin cytoskeleton organization	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P42345	P	From MGI
	GO:0043022	ribosome binding	MGI:MGI:4867369 PMID:21045808^[7]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0043200	response to amino acid stimulus	MGI:MGI:3510095 PMID:15467718^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0043200	response to amino acid stimulus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P42345	P	From MGI
	GO:0043610	regulation of carbohydrate utilization	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P42346	P	From MGI
	GO:0045727	positive regulation of translation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P42346	P	From MGI
	GO:0045727	positive regulation of translation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P42345	P	From MGI
	GO:0045792	negative regulation of cell size	MGI:MGI:3610880 PMID:16286931^[12]	IGI: Inferred from Genetic Interaction	MGI:MGI:1929183	P	From MGI
	GO:0045792	negative regulation of cell size	MGI:MGI:3610880 PMID:16286931^[12]	ISO: Inferred from Sequence Orthology	UniProtKB:P42346	P	From MGI
	GO:0045792	negative regulation of cell size	MGI:MGI:3613118 PMID:15185396^[13]	IGI: Inferred from Genetic Interaction	MGI:MGI:1929183	P	From MGI
	GO:0045859	regulation of protein kinase activity	MGI:MGI:3613118 PMID:15185396^[13]	IGI: Inferred from Genetic Interaction	MGI:MGI:1929183	P	From MGI
	GO:0045945	positive regulation of transcription from RNA polymerase III promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P42345	P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:3510095 PMID:15467718^[9]	ISO: Inferred from Sequence Orthology	UniProtKB:P42345	P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P42346	P	From MGI
	GO:0046889	positive regulation of lipid biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P42345	P	From MGI
	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	MGI:MGI:3510095 PMID:15467718^[9]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0051219	phosphoprotein binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P42345	F	From MGI
	GO:0051496	positive regulation of stress fiber assembly	MGI:MGI:3510095 PMID:15467718^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0051534	negative regulation of NFAT protein import into nucleus	MGI:MGI:3795069 PMID:18347059^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0051897	positive regulation of protein kinase B signaling cascade	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P42346	P	From MGI
	GO:0070438	mTOR-FKBP12-rapamycin complex	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P42346	C	From MGI
	GO:0071456	cellular response to hypoxia	MGI:MGI:3654795 PMID:16915281^[4]	IDA: Inferred from Direct Assay		P	From MGI
colocalizes_with	GO:0016605	PML body	MGI:MGI:3654795 PMID:16915281^[4]	IDA: Inferred from Direct Assay		C	From MGI
colocalizes_with	GO:0030425	dendrite	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P42346	C	From MGI
colocalizes_with	GO:0043025	neuronal cell body	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P42346	C	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Hentges KE et al. (2001) FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse. Proc Natl Acad Sci U S A 98: 13796-801 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Yang TT et al. (2008) Integration of protein kinases mTOR and extracellular signal-regulated kinase 5 in regulating nucleocytoplasmic localization of NFATc4. Mol Cell Biol 28: 3489-501 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Kim J et al. (2011) AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 13: 132-41 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Bernardi R et al. (2006) PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. Nature 442: 779-85 PubMed GONUTS page
↑ Hara K et al. (2002) Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 110: 177-89 PubMed GONUTS page
↑ Takai H et al. (2010) Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes. Genes Dev 24: 2019-30 PubMed GONUTS page
↑ ^7.0 ^7.1 Oh WJ et al. (2010) mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. EMBO J 29: 3939-51 PubMed GONUTS page
↑ Pearson HB et al. (2008) Lkb1 deficiency causes prostate neoplasia in the mouse. Cancer Res 68: 2223-32 PubMed GONUTS page
↑ ^9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 ^9.11 ^9.12 ^9.13 Jacinto E et al. (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 6: 1122-8 PubMed GONUTS page
↑ De Miguel MP et al. (2002) Dissection of the c-Kit signaling pathway in mouse primordial germ cells by retroviral-mediated gene transfer. Proc Natl Acad Sci U S A 99: 10458-63 PubMed GONUTS page
↑ Cao Y et al. (2006) Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis. J Biol Chem 281: 20483-93 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Tavazoie SF et al. (2005) Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2. Nat Neurosci 8: 1727-34 PubMed GONUTS page
↑ ^13.0 ^13.1 Uhlmann EJ et al. (2004) Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation. Glia 47: 180-8 PubMed GONUTS page

[PMID:11707573-0] 1.0 ^1.1 Hentges KE et al. (2001) FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse. Proc Natl Acad Sci U S A 98: 13796-801 PubMed GONUTS page

[PMID:18347059-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Yang TT et al. (2008) Integration of protein kinases mTOR and extracellular signal-regulated kinase 5 in regulating nucleocytoplasmic localization of NFATc4. Mol Cell Biol 28: 3489-501 PubMed GONUTS page

[PMID:21258367-2] 3.0 ^3.1 ^3.2 ^3.3 Kim J et al. (2011) AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 13: 132-41 PubMed GONUTS page

[PMID:16915281-3] 4.0 ^4.1 ^4.2 ^4.3 Bernardi R et al. (2006) PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. Nature 442: 779-85 PubMed GONUTS page

[PMID:12150926-4] Hara K et al. (2002) Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 110: 177-89 PubMed GONUTS page

[PMID:20801936-5] Takai H et al. (2010) Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes. Genes Dev 24: 2019-30 PubMed GONUTS page

[PMID:21045808-6] 7.0 ^7.1 Oh WJ et al. (2010) mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. EMBO J 29: 3939-51 PubMed GONUTS page

[PMID:18381428-7] Pearson HB et al. (2008) Lkb1 deficiency causes prostate neoplasia in the mouse. Cancer Res 68: 2223-32 PubMed GONUTS page

[PMID:15467718-8] 9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 ^9.11 ^9.12 ^9.13 Jacinto E et al. (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 6: 1122-8 PubMed GONUTS page

[PMID:12140361-9] De Miguel MP et al. (2002) Dissection of the c-Kit signaling pathway in mouse primordial germ cells by retroviral-mediated gene transfer. Proc Natl Acad Sci U S A 99: 10458-63 PubMed GONUTS page

[PMID:16714284-10] Cao Y et al. (2006) Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis. J Biol Chem 281: 20483-93 PubMed GONUTS page

[PMID:16286931-11] 12.0 ^12.1 ^12.2 ^12.3 Tavazoie SF et al. (2005) Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2. Nat Neurosci 8: 1727-34 PubMed GONUTS page

[PMID:15185396-12] 13.0 ^13.1 Uhlmann EJ et al. (2004) Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation. Glia 47: 180-8 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Mtor ( synonyms: FKBP-rapamycin-associated protein FRAP, flat, Frap1, RAFT1, RAPT1 )
Protein Name(s)	mechanistic target of rapamycin (serine/threonine kinase),
External Links
MGI	MGI:1928394

MGI:Mtor

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