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MGI:Mtf1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Mtf1 ( synonyms: metal response element-binding transcription factor 1, metalloregulatory transcription factor, MTF-1, Thyls ) | |
| Protein Name(s) | metal response element binding transcription factor 1, | |
| External Links | ||
| MGI | MGI:101786 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000979 |
RNA polymerase II core promoter sequence-specific DNA binding |
MGI:MGI:3820854 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0001047 |
core promoter binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003676 |
nucleic acid binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:1266982 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:1926646 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:1926647 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:3694414 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:1926646 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1926646 |
IC: Inferred by Curator |
GO:0003700 |
C |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0805 |
P |
From MGI |
||
| GO:0006979 |
response to oxidative stress |
MGI:MGI:1266982 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2182939 |
P |
From MGI |
||
| GO:0008270 |
zinc ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0035035 |
histone acetyltransferase binding |
MGI:MGI:3820854 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:1926646 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2182939 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:1266982 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:1926647 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046686 |
response to cadmium ion |
MGI:MGI:1266982 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2182939 |
P |
From MGI |
||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Kimura T et al. (2008) Chromium(VI) inhibits mouse metallothionein-I gene transcription by preventing the zinc-dependent formation of an MTF-1-p300 complex. Biochem J 415: 477-82 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Günes C et al. (1998) Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1. EMBO J 17: 2846-54 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Langmade SJ et al. (2000) The transcription factor MTF-1 mediates metal regulation of the mouse ZnT1 gene. J Biol Chem 275: 34803-9 PubMed GONUTS page
- ↑ 4.0 4.1 Koza RA et al. (2000) Synergistic gene interactions control the induction of the mitochondrial uncoupling protein (Ucp1) gene in white fat tissue. J Biol Chem 275: 34486-92 PubMed GONUTS page
- ↑ Starzynski RR et al. (2006) STAT5 proteins are involved in down-regulation of iron regulatory protein 1 gene expression by nitric oxide. Biochem J 400: 367-75 PubMed GONUTS page
