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MGI:Mta2

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Mta2 ( synonyms: mmta2, Mta1l1 )
Protein Name(s) metastasis-associated gene family, member 2,
External Links
MGI MGI:1346340

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000118

histone deacetylase complex

MGI:MGI:1342369
PMID:10444591[1]

IPI: Inferred from Physical Interaction

C

From MGI

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

MGI:MGI:2154000
PMID:11749719[2]

IDA: Inferred from Direct Assay

P

From MGI

GO:0000989

transcription factor binding transcription factor activity

MGI:MGI:4844227
PMID:20636338[3]

IDA: Inferred from Direct Assay

F

From MGI

GO:0001085

RNA polymerase II transcription factor binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O94776

F

From MGI

GO:0003677

DNA binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

From MGI

GO:0003677

DNA binding

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR001025
InterPro:IPR009057
InterPro:IPR001005

F

From MGI

GO:0003700

sequence-specific DNA binding transcription factor activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR000679

F

From MGI

GO:0004407

histone deacetylase activity

MGI:MGI:1342369
PMID:10444591[1]

IDA: Inferred from Direct Assay

F

From MGI

GO:0005515

protein binding

MGI:MGI:2178733
PMID:11836251[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q60973
UniProtKB:Q9R190
UniProtKB:O09106
UniProtKB:P70288
UniProtKB:Q9ER74

F

From MGI

GO:0005515

protein binding

MGI:MGI:2683041
PMID:14645126[5]

IPI: Inferred from Physical Interaction

UniProtKB:Q60973
UniProtKB:Q60972
UniProtKB:O09106

F

From MGI

GO:0005515

protein binding

MGI:MGI:3619832
PMID:16462733[6]

IPI: Inferred from Physical Interaction

UniProtKB:O09106
UniProtKB:Q9Z2D8

F

From MGI

GO:0005515

protein binding

MGI:MGI:4422158
PMID:19654328[7]

IPI: Inferred from Physical Interaction

UniProtKB:O35615-1

F

From MGI

GO:0005515

protein binding

MGI:MGI:4844227
PMID:20636338[3]

IPI: Inferred from Physical Interaction

UniProtKB:P23772

F

From MGI

GO:0005634

nucleus

MGI:MGI:2154000
PMID:11749719[2]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3619832
PMID:16462733[6]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O94776

C

From MGI

GO:0005667

transcription factor complex

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O94776

C

From MGI

GO:0006323

DNA packaging

MGI:MGI:1342369
PMID:10444591[1]

TAS: Traceable Author Statement

P

From MGI

GO:0006338

chromatin remodeling

MGI:MGI:2683041
PMID:14645126[5]

TAS: Traceable Author Statement

P

From MGI

GO:0006355

regulation of transcription, DNA-dependent

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR000679

P

From MGI

GO:0008270

zinc ion binding

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR000679

F

From MGI

GO:0016575

histone deacetylation

MGI:MGI:1342369
PMID:10444591[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0016581

NuRD complex

MGI:MGI:2683041
PMID:14645126[5]

IDA: Inferred from Direct Assay

C

From MGI

GO:0016581

NuRD complex

MGI:MGI:3619832
PMID:16462733[6]

IPI: Inferred from Physical Interaction

UniProtKB:Q8K4B0
UniProtKB:Q9Z2D8
UniProtKB:O09106

C

From MGI

GO:0016581

NuRD complex

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O94776

C

From MGI

GO:0016585

chromatin remodeling complex

MGI:MGI:1342369
PMID:10444591[1]

IPI: Inferred from Physical Interaction

C

From MGI

GO:0043565

sequence-specific DNA binding

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR000679

F

From MGI

GO:0044212

transcription regulatory region DNA binding

MGI:MGI:4844227
PMID:20636338[3]

IDA: Inferred from Direct Assay

F

From MGI

GO:0045892

negative regulation of transcription, DNA-dependent

MGI:MGI:4844227
PMID:20636338[3]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:2154000
PMID:11749719[2]

IDA: Inferred from Direct Assay

P

From MGI

GO:0046872

metal ion binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 1.4 Zhang Y et al. (1999) Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev 13: 1924-35 PubMed GONUTS page
  2. 2.0 2.1 2.2 Matsusue K et al. (2001) Characterization of mouse metastasis-associated gene 2: genomic structure, nuclear localization signal, and alternative potentials as transcriptional activator and repressor. DNA Cell Biol 20: 603-11 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Hwang SS et al. (2010) GATA-binding protein-3 regulates T helper type 2 cytokine and ifng loci through interaction with metastasis-associated protein 2. Immunology 131: 50-8 PubMed GONUTS page
  4. Kiefer SM et al. (2002) Murine Sall1 represses transcription by recruiting a histone deacetylase complex. J Biol Chem 277: 14869-76 PubMed GONUTS page
  5. 5.0 5.1 5.2 Zoltewicz JS et al. (2004) Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis. Development 131: 3-14 PubMed GONUTS page
  6. 6.0 6.1 6.2 Kaji K et al. (2006) The NuRD component Mbd3 is required for pluripotency of embryonic stem cells. Nat Cell Biol 8: 285-92 PubMed GONUTS page
  7. Snow JW & Orkin SH (2009) Translational isoforms of FOG1 regulate GATA1-interacting complexes. J Biol Chem 284: 29310-9 PubMed GONUTS page
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