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MGI:Msx1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Msx1 ( synonyms: Hox-7, Hox7, Hox7.1, msh, muscle-segment homeobox ) | |
| Protein Name(s) | homeobox, msh-like 1, | |
| External Links | ||
| MGI | MGI:97168 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0048701 |
embryonic cranial skeleton morphogenesis |
IMP: Inferred from Mutant Phenotype |
P |
Fig. 7 shows that inactivating Msx1/2 by injections of tamoxifen retards growth of frontal and parietal bone formation of the skull, but not heterotopic bone. |
complete | |||
| GO:0090131 |
mesenchyme migration |
IEP: Inferred from Expression Pattern |
P |
Fig. 4 shows the expression of Msx1/2 in the migrating cranial mesenchyme; Msx1 at E12.5 overlaps with Msx2 expression; at E13.5 Msx1 is localized to the meninges, internal to Msx2 in the mesenchymal layer. |
complete | |||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:1098935 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3047475 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3603095 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3697003 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:2137495 |
P |
From MGI |
||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4440723 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4440723 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99146 |
P |
From MGI |
||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4461870 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98494 |
P |
From MGI |
||
| GO:0000902 |
cell morphogenesis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0000982 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity |
MGI:MGI:4461870 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0001701 |
in utero embryonic development |
MGI:MGI:3720542 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926386 |
P |
From MGI |
||
| GO:0002039 |
p53 binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003007 |
heart morphogenesis |
MGI:MGI:3720542 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1926386 |
P |
From MGI |
||
| GO:0003198 |
epithelial to mesenchymal transition involved in endocardial cushion formation |
MGI:MGI:3810851 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97169 |
P |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:1098935 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:3047475 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:66301 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1278140 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3578563 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3697003 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4440723 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4440723 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99146 |
C |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005667 |
transcription factor complex |
MGI:MGI:4461870 |
IPI: Inferred from Physical Interaction |
C |
From MGI |
|||
| GO:0007507 |
heart development |
MGI:MGI:3720542 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97169 |
P |
From MGI |
||
| GO:0007517 |
muscle organ development |
MGI:MGI:3047475 |
IPI: Inferred from Physical Interaction |
P |
From MGI |
|||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:3720542 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1926386 |
P |
From MGI |
||
| GO:0009952 |
anterior/posterior pattern specification |
MGI:MGI:4948979 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97169 |
P |
From MGI |
||
| GO:0023019 |
signal transduction involved in regulation of gene expression |
MGI:MGI:4948979 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97169 |
P |
From MGI |
||
| GO:0030262 |
apoptotic nuclear change |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030308 |
negative regulation of cell growth |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030326 |
embryonic limb morphogenesis |
MGI:MGI:3580732 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97169 |
P |
From MGI |
||
| GO:0030326 |
embryonic limb morphogenesis |
MGI:MGI:3851667 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97169 |
P |
From MGI |
||
| GO:0030509 |
BMP signaling pathway |
MGI:MGI:3720542 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1926386 |
P |
From MGI |
||
| GO:0030509 |
BMP signaling pathway |
MGI:MGI:3806189 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030509 |
BMP signaling pathway |
MGI:MGI:4429763 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030513 |
positive regulation of BMP signaling pathway |
MGI:MGI:3810851 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97169 |
P |
From MGI |
||
| GO:0030900 |
forebrain development |
MGI:MGI:3046130 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1933766 |
P |
From MGI |
||
| GO:0030900 |
forebrain development |
MGI:MGI:3613203 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1933766 |
P |
From MGI |
||
| GO:0030901 |
midbrain development |
MGI:MGI:3046130 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1933766 |
P |
From MGI |
||
| GO:0034504 |
protein localization to nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0035115 |
embryonic forelimb morphogenesis |
MGI:MGI:4948979 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97169 |
P |
From MGI |
||
| GO:0035116 |
embryonic hindlimb morphogenesis |
MGI:MGI:4948979 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97169 |
P |
From MGI |
||
| GO:0035880 |
embryonic nail plate morphogenesis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0035880 |
embryonic nail plate morphogenesis |
MGI:MGI:4948979 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97169 |
P |
From MGI |
||
| GO:0042474 |
middle ear morphogenesis |
MGI:MGI:3611627 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1933766 |
P |
From MGI |
||
| GO:0042475 |
odontogenesis of dentin-containing tooth |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042476 |
odontogenesis |
MGI:MGI:4453942 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97493 |
P |
From MGI |
||
| GO:0042481 |
regulation of odontogenesis |
MGI:MGI:4453942 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97493 |
P |
From MGI |
||
| GO:0042733 |
embryonic digit morphogenesis |
MGI:MGI:4948979 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97169 |
P |
From MGI |
||
| GO:0042981 |
regulation of apoptotic process |
MGI:MGI:3851667 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98297 |
P |
From MGI |
||
| GO:0043065 |
positive regulation of apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:3720542 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1926386 |
P |
From MGI |
||
| GO:0043392 |
negative regulation of DNA binding |
MGI:MGI:3697003 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:83223 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:3047475 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:1336531 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88180 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:1336531 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98297 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:83672 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95515 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:83672 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97168 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:83672 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926386 |
P |
From MGI |
||
| GO:0048863 |
stem cell differentiation |
MGI:MGI:3723565 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97169 |
P |
From MGI |
||
| GO:0050821 |
protein stabilization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051154 |
negative regulation of striated muscle cell differentiation |
MGI:MGI:4440723 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0051154 |
negative regulation of striated muscle cell differentiation |
MGI:MGI:4440723 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99146 |
P |
From MGI |
||
| GO:0051216 |
cartilage development |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_112321 |
P |
From MGI |
||
| GO:0060021 |
palate development |
MGI:MGI:3611627 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1933766 |
P |
From MGI |
||
| GO:0060325 |
face morphogenesis |
MGI:MGI:3611627 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1933766 |
P |
From MGI |
||
| GO:0060325 |
face morphogenesis |
MGI:MGI:4453942 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97493 |
P |
From MGI |
||
| GO:0060325 |
face morphogenesis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060349 |
bone morphogenesis |
MGI:MGI:3608570 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1933766 |
P |
From MGI |
||
| GO:0060349 |
bone morphogenesis |
MGI:MGI:3611627 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1933766 |
P |
From MGI |
||
| GO:0060349 |
bone morphogenesis |
MGI:MGI:3723565 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97169 |
P |
From MGI |
||
| GO:0060536 |
cartilage morphogenesis |
MGI:MGI:3608570 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1933766 |
P |
From MGI |
||
| GO:0061180 |
mammary gland epithelium development |
MGI:MGI:1355063 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97169 |
P |
From MGI |
||
| GO:0061312 |
BMP signaling pathway involved in heart development |
MGI:MGI:3810851 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97169 |
P |
From MGI |
||
| GO:2000678 |
negative regulation of transcription regulatory region DNA binding |
MGI:MGI:1278140 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96785 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Roybal PG et al. (2010) Inactivation of Msx1 and Msx2 in neural crest reveals an unexpected role in suppressing heterotopic bone formation in the head. Dev Biol 343: 28-39 PubMed GONUTS page
- ↑ 2.0 2.1 Sarapura VD et al. (1997) Msx1 is present in thyrotropic cells and binds to a consensus site on the glycoprotein hormone alpha-subunit promoter. Mol Endocrinol 11: 1782-94 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Lee H et al. (2004) MSX1 cooperates with histone H1b for inhibition of transcription and myogenesis. Science 304: 1675-8 PubMed GONUTS page
- ↑ Rave-Harel N et al. (2005) The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1. J Biol Chem 280: 30975-83 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Hayashi K et al. (2006) Bone morphogenetic protein-induced MSX1 and MSX2 inhibit myocardin-dependent smooth muscle gene transcription. Mol Cell Biol 26: 9456-70 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Song YJ & Lee H (2010) YB1/p32, a nuclear Y-box binding protein 1, is a novel regulator of myoblast differentiation that interacts with Msx1 homeoprotein. Exp Cell Res 316: 517-29 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Boogerd KJ et al. (2008) Msx1 and Msx2 are functional interacting partners of T-box factors in the regulation of Connexin43. Cardiovasc Res 78: 485-93 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 8.5 Chen YH et al. (2007) Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract. Dev Biol 308: 421-37 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Chen YH et al. (2008) Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium. BMC Dev Biol 8: 75 PubMed GONUTS page
- ↑ Kuzuoka M et al. (1994) Murine homeobox-containing gene, Msx-1: analysis of genomic organization, promoter structure, and potential autoregulatory cis-acting elements. Genomics 21: 85-91 PubMed GONUTS page
- ↑ 11.0 11.1 Bendall AJ et al. (1998) Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity. Differentiation 63: 151-7 PubMed GONUTS page
- ↑ Ogawa T et al. (2005) Studies on Pax9-Msx1 protein interactions. Arch Oral Biol 50: 141-5 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 13.3 13.4 13.5 Bensoussan-Trigano V et al. (2011) Msx1 and Msx2 in limb mesenchyme modulate digit number and identity. Dev Dyn 240: 1190-202 PubMed GONUTS page
- ↑ Lallemand Y et al. (2005) Analysis of Msx1; Msx2 double mutants reveals multiple roles for Msx genes in limb development. Development 132: 3003-14 PubMed GONUTS page
- ↑ 15.0 15.1 Lallemand Y et al. (2009) Msx genes are important apoptosis effectors downstream of the Shh/Gli3 pathway in the limb. Dev Biol 331: 189-98 PubMed GONUTS page
- ↑ Cho A et al. (2008) FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev Biol 321: 27-39 PubMed GONUTS page
- ↑ Misra K & Matise MP (2010) A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling. Dev Biol 337: 74-83 PubMed GONUTS page
- ↑ 18.0 18.1 Ramos C et al. (2004) Msx1 disruption leads to diencephalon defects and hydrocephalus. Dev Dyn 230: 446-60 PubMed GONUTS page
- ↑ Fernández-Llebrez P et al. (2004) Msx1-deficient mice fail to form prosomere 1 derivatives, subcommissural organ, and posterior commissure and develop hydrocephalus. J Neuropathol Exp Neurol 63: 574-86 PubMed GONUTS page
- ↑ 20.0 20.1 20.2 20.3 Levi G et al. (2006) Msx1 and Dlx5 act independently in development of craniofacial skeleton, but converge on the regulation of Bmp signaling in palate formation. Mech Dev 123: 3-16 PubMed GONUTS page
- ↑ 21.0 21.1 21.2 Nakatomi M et al. (2010) Genetic interactions between Pax9 and Msx1 regulate lip development and several stages of tooth morphogenesis. Dev Biol 340: 438-49 PubMed GONUTS page
- ↑ Iler N & Abate-Shen C (1996) Rapid identification of homeodomain binding sites in the Wnt-5a gene using an immunoprecipitation strategy. Biochem Biophys Res Commun 227: 257-65 PubMed GONUTS page
- ↑ 23.0 23.1 Zhang Y et al. (1999) Msx1 is required for the induction of Patched by Sonic hedgehog in the mammalian tooth germ. Dev Dyn 215: 45-53 PubMed GONUTS page
- ↑ 24.0 24.1 24.2 Chen Y et al. (1996) Msx1 controls inductive signaling in mammalian tooth morphogenesis. Development 122: 3035-44 PubMed GONUTS page
- ↑ 25.0 25.1 Han J et al. (2007) Concerted action of Msx1 and Msx2 in regulating cranial neural crest cell differentiation during frontal bone development. Mech Dev 124: 729-45 PubMed GONUTS page
- ↑ 26.0 26.1 Orestes-Cardoso S et al. (2002) Msx1 is a regulator of bone formation during development and postnatal growth: in vivo investigations in a transgenic mouse model. Connect Tissue Res 43: 153-60 PubMed GONUTS page
- ↑ Satokata I et al. (2000) Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation. Nat Genet 24: 391-5 PubMed GONUTS page
