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MGI:Mstn

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Mstn ( synonyms: Gdf8 )
Protein Name(s) myostatin,
External Links
MGI MGI:95691

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005102

receptor binding

MGI:MGI:2137985
PMID:11459935[1]

IPI: Inferred from Physical Interaction

UniProtKB:P27040
UniProtKB:P27038

F

From MGI

GO:0005102

receptor binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O14793

F

From MGI

GO:0005125

cytokine activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0202

F

From MGI

GO:0005515

protein binding

MGI:MGI:2676508
PMID:12595574[2]

IPI: Inferred from Physical Interaction

UniProtKB:Q7TQN3

F

From MGI

GO:0005515

protein binding

MGI:MGI:4820714
PMID:18596030[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q96NZ8
UniProtKB:Q8TEU8

F

From MGI

GO:0005576

extracellular region

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0964

C

From MGI

GO:0005615

extracellular space

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:O35312

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:O35312

C

From MGI

GO:0007179

transforming growth factor beta receptor signaling pathway

MGI:MGI:2676508
PMID:12595574[2]

IDA: Inferred from Direct Assay

P

From MGI

GO:0008083

growth factor activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0339

F

From MGI

GO:0008083

growth factor activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR001839
InterPro:IPR001111
InterPro:IPR017948

F

From MGI

GO:0008201

heparin binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0358

F

From MGI

GO:0014741

negative regulation of muscle hypertrophy

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:O35312

P

From MGI

GO:0040007

growth

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR001111

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O14793

P

From MGI

GO:0048632

negative regulation of skeletal muscle tissue growth

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:O35312

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Lee SJ & McPherron AC (2001) Regulation of myostatin activity and muscle growth. Proc Natl Acad Sci U S A 98: 9306-11 PubMed GONUTS page
  2. 2.0 2.1 Hill JJ et al. (2003) Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains. Mol Endocrinol 17: 1144-54 PubMed GONUTS page
  3. Kondás K et al. (2008) Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11. J Biol Chem 283: 23677-84 PubMed GONUTS page
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