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MGI:Mre11a
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Mre11a | |
| Protein Name(s) | meiotic recombination 11 homolog A (S. cerevisiae), | |
| External Links | ||
| MGI | MGI:1100512 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000075 |
cell cycle checkpoint |
MGI:MGI:2683367 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3027036 |
P |
From MGI |
||
| GO:0000075 |
cell cycle checkpoint |
MGI:MGI:3805397 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3027036 |
P |
From MGI |
||
| GO:0000790 |
nuclear chromatin |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_071615 |
C |
From MGI |
||
| GO:0000794 |
condensed nuclear chromosome |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_071615 |
C |
From MGI |
||
| GO:0004518 |
nuclease activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0540 |
F |
From MGI |
||
| GO:0004519 |
endonuclease activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0255 |
F |
From MGI |
||
| GO:0004519 |
endonuclease activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004527 |
exonuclease activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0269 |
F |
From MGI |
||
| GO:0004527 |
exonuclease activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2667543 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3053255 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_071615 |
C |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005654 |
nucleoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_071615 |
C |
From MGI |
||
| GO:0006259 |
DNA metabolic process |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0006281 |
DNA repair |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0234 |
P |
From MGI |
||
| GO:0006302 |
double-strand break repair |
MGI:MGI:3707920 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3027036 |
P |
From MGI |
||
| GO:0006974 |
response to DNA damage stimulus |
MGI:MGI:3718866 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007062 |
sister chromatid cohesion |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007126 |
meiosis |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0469 |
P |
From MGI |
||
| GO:0007129 |
synapsis |
MGI:MGI:3707920 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3027036 |
P |
From MGI |
||
| GO:0008022 |
protein C-terminus binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008283 |
cell proliferation |
MGI:MGI:1096106 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0016787 |
hydrolase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0378 |
F |
From MGI |
||
| GO:0016787 |
hydrolase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0030145 |
manganese ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0030870 |
Mre11 complex |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0031954 |
positive regulation of protein autophosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032508 |
DNA duplex unwinding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032876 |
negative regulation of DNA endoreduplication |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0033674 |
positive regulation of kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048471 |
perinuclear region of cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_071615 |
C |
From MGI |
||
| GO:0051276 |
chromosome organization |
MGI:MGI:2683367 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3027036 |
P |
From MGI |
||
| GO:0090305 |
nucleic acid phosphodiester bond hydrolysis |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0255 |
P |
From MGI |
||
| GO:0090305 |
nucleic acid phosphodiester bond hydrolysis |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Theunissen JW et al. (2003) Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice. Mol Cell 12: 1511-23 PubMed GONUTS page
- ↑ Stracker TH et al. (2008) Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage. Mol Cell 31: 21-32 PubMed GONUTS page
- ↑ Franchitto A et al. (2003) The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase. Oncogene 22: 2110-20 PubMed GONUTS page
- ↑ Sengupta S et al. (2004) Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J Cell Biol 166: 801-13 PubMed GONUTS page
- ↑ 5.0 5.1 Cherry SM et al. (2007) The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis. Curr Biol 17: 373-8 PubMed GONUTS page
- ↑ Cho YW et al. (2007) PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J Biol Chem 282: 20395-406 PubMed GONUTS page
- ↑ Xiao Y & Weaver DT (1997) Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells. Nucleic Acids Res 25: 2985-91 PubMed GONUTS page
